A nanocomposite material for adsorbing phosphorus and its preparation and application
A nanocomposite and phosphorus adsorption technology, applied in the field of nanomaterials, can solve the problems of inability to improve endogenous phosphorus increase, limited patient tolerance, and rebound increase of blood phosphorus, so as to reduce the risk of cardiovascular disease and ease the Biodegradable, high phosphorus adsorption effect
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Embodiment 1
[0029] Preparation of Liposome / Silamer:
[0030] (1) Mix phospholipid molecule DSPE-PEG5000-COOH (Xi’an Ruixi Biotechnology Co., Ltd.) and lecithin at a ratio of 1:20, add ethanol and stir thoroughly to obtain clear liquid 1.
[0031] (2) Pour 500ml of sterile double-distilled water into a sterilized beaker, slowly inject liquid 1 into the beaker, stir while injecting, to obtain liposomes, centrifuge, remove the supernatant, and repeat with a 100nm filter Filter 10 times to obtain homogeneous liposomes with a particle size of about 100 nm.
[0032] (3) Dissolve the purchased chemical raw material 2-propene-1-amine and the polymer carbonate of epichlorohydrin (trade name: Silam Carbonate) in sterilized double distilled water, fully stir to obtain a suspension Liquid 2.
[0033] (4) Pour suspension 2 into the prepared homogeneous liposomes, then add 150ml of N-hydroxysuccinimide (NHS) and 1-(3-dimethylaminopropyl)-3-ethane Carbodiimide hydrochloride (EDC·HCL), stirred for 2 h...
Embodiment 2
[0037] Adopt the preparation method similar to embodiment 1, difference is:
[0038] (1) The molar ratio of DSPE-PEG5000-COOH to lecithin is 1:15;
[0039] (2) the mass ratio of the polymer carbonate of nano-carrier microspheres and 2-propylene-1-amine and epichlorohydrin is 3:1;
[0040] (3) The added N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and the added 2-propen-1-amine and epoxy The mass ratio of the polymer carbonate of chloropropane is 20:20:1;
[0041] (4) The storage temperature of the final product is -10°C.
[0042] The material prepared above was used to give mice with hyperphosphatemia, and it was observed that the blood phosphorus content of the mice was controlled within 2 hours and lasted for more than 3 days.
Embodiment 3
[0044] Adopt the preparation method similar to embodiment 1, difference is:
[0045] (1) The molar ratio of DSPE-PEG5000-COOH to lecithin is 1:25;
[0046] (2) the mass ratio of the polymer carbonate of nano-carrier microspheres and 2-propylene-1-amine and epichlorohydrin is 12:1;
[0047] (3) The added N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and the added 2-propen-1-amine and epoxy The mass ratio of the polymer carbonate of chloropropane is 100:100:1;
[0048] (4) The storage temperature of the final product is -30°C.
[0049] The material prepared above was used to give mice with hyperphosphatemia, and it was observed that the blood phosphorus content of the mice was controlled within 1.5 hours and lasted for more than 3 days.
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