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Intestinal dialysis composition for pet dogs and cats and preparation method of intestinal dialysis composition

A composition and technology for dogs and cats, applied in the field of pet medical treatment, can solve the problems of large damage to pets, failure of peritoneal ultrafiltration, loss of nutrients in dogs and cats, etc., to promote amino acid synthesis protein, avoid large animal damage, and improve muscle protein. Decomposition promoting effect

Active Publication Date: 2020-02-21
JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high cost and high technical requirements of hemodialysis and kidney transplantation, it is still difficult to apply in small animal clinics in my country. As an important part of renal replacement therapy, peritoneal dialysis requires costs and technical requirements The requirements are relatively low, and it is relatively easy to be accepted by animal owners. It has been used in the treatment of dogs and cats with renal failure.
[0003] At present, the peritoneal dialysis solution of dogs and cats generally uses the dialysis solution used by humans with glucose as the main osmotic agent. Due to its high sugar, hyperosmosis, low pH value and the production of glucose degradation products, it will cause changes in the structure and function of the peritoneum, and It will eventually lead to peritoneal fibrosis and peritoneal ultrafiltration failure. In addition, it can also lead to the loss of nutrients in dogs and cats, and accompanying diseases such as hypoproteinemia, hyperlipidemia, and hyperinsulinemia, which seriously affect the health of pet dogs and cats. Quality of life, increased financial burden and emotional distress for pet owners
[0004] Both hemodialysis and peritoneal dialysis achieve the purpose of reducing blood uremic toxins such as uremic toxins through the diffusion principle of uremic toxins such as urea, but there are disadvantages such as high cost, great harm to pets, and inconvenient operation.

Method used

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  • Intestinal dialysis composition for pet dogs and cats and preparation method of intestinal dialysis composition
  • Intestinal dialysis composition for pet dogs and cats and preparation method of intestinal dialysis composition
  • Intestinal dialysis composition for pet dogs and cats and preparation method of intestinal dialysis composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A composition for intestinal dialysis of pet dogs and cats, comprising the following components: 10 g of raw rhubarb, 10 g of chitosan, 10 g of calcium butyrate, 100 g of modified zeolite, and 250 ml of acetic acid with a volume fraction of 4%.

[0026] The preparation method of the intestinal dialysis composition for pet dogs and cats comprises the following steps:

[0027] (1) Take the raw rhubarb, chitosan, and calcium butyrate in the above amounts and dissolve them in 250ml of acetic acid with a volume fraction of 4%, and stir to fully dissolve them to obtain a solution;

[0028] (2) Weigh 116g of sodium chloride, 55g of calcium chloride and 37g of potassium chloride and dissolve them in 1000ml of deionized water, fully dissolve to make a salt solution, add natural orthorhombic zeolite at 100g / L, and place in a constant temperature magnetic stirrer above, the reaction temperature is 25°C, the modification time is 24h, and then the precipitate is left standing and wa...

Embodiment 2

[0032] A composition for intestinal dialysis of pet dogs and cats, comprising the following components: 15g of raw rhubarb, 15g of chitosan, 10g of calcium butyrate, 75g of modified zeolite, and 250ml of acetic acid with a volume fraction of 4%.

[0033] Its preparation steps are all the same as in Example 1 except that the parts of each component are different.

Embodiment 3

[0035] A composition for intestinal dialysis of pet dogs and cats, comprising the following components: 10 g of raw rhubarb, 10 g of chitosan, 10 g of calcium butyrate, 70 g of modified zeolite, and 250 ml of acetic acid with a volume fraction of 4%.

[0036] Its preparation steps are all the same as in Example 1 except that the parts of each component are different.

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Abstract

The invention discloses an intestinal dialysis composition for pet dogs and cats and a preparation method of the intestinal dialysis composition and belongs to the field of veterinary care. The dialysis composition comprises the following components: 10-20g of unprocessed rehmannia roots, 10-20g of chitosan, 10-20g of calcium butyrate, 50-100g of modified zeolite and 200-300ml of acetic acid witha volume percentage of 4%. The preparation method comprises the following steps: sufficiently dissolving the unprocessed rehmannia roots, the chitosan and the calcium butyrate into the acetic acid, adding the modified zeolite, blending the components into a paste, performing sufficient infiltration, performing pelletizing by using a pelletizer, and performing drying at 60 DEG C for 4 hours, so asto obtain a finished product of which the particle size is 0.8-1.2mm. Components of the intestinal dialysis composition for pet dogs and cats take synergetic effects into play, uremia toxins such as urea and decomposition products, namely substances such as ammonia, phosphate and creatinine, of the uremia toxins, in intestines, can be adsorbed, small molecule substances such as the uremia toxins such as urea in blood can be promoted to be discharged to enterocoels, then the concentration of the small molecule substances in blood can be reduced, hyperazotemic and hyperphosphatemia caused by kidney failure can be relieved, and recovery of kidney failure can be facilitated. The composition is economic and practical and convenient to operate.

Description

technical field [0001] The invention belongs to the pet medical field, in particular to an intestinal dialysis composition for preventing and treating renal failure in pet dogs and cats. Background technique [0002] Studies have shown that uremic toxins such as serum urea and creatinine come from protein decomposition and intestinal absorption, and are mainly excreted through the kidneys. When kidney disease occurs, it can cause hyperureaemia. Uremic toxins such as urea and its metabolite hydrocyanate can inhibit the activity of many enzymes (monoammonium oxidase, xanthine oxidase, etc.), affect cell functions, and promote the occurrence and development of diseases, thus reducing blood urea and other uremia. Toxins hold the key to treating kidney failure in pets. The treatment of renal failure in dogs and cats mainly adopts symptomatic treatment to improve various clinical symptoms caused by excretory function, regulatory function and biosynthetic dysfunction, thereby prol...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61P7/08A61P13/12A61K31/19A61K31/722A61K33/06
CPCA61K36/708A61K31/722A61K33/06A61K31/19A61P13/12A61P7/08A61K2300/00
Inventor 陆江朱道仙卢劲晔赵学刚袁华根刘静卢炜郝福星吴植刘莉
Owner JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
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