Selenium protein liver nourishing, eye protecting and hangover alleviating gradient composite formula product and intelligent wearable equipment health management system

By combining high organic selenium-rate DYG selenium protein with traditional Chinese medicine, a gradient composite formula product and smart wearable device is constructed, which solves the problems of single functions and obvious side effects of existing alcohol-relieving drugs, and achieves accelerated alcohol metabolism and comprehensive liver and eyes Protection improves the effectiveness of alcohol health management.

CN119235019APending Publication Date: 2025-01-03沈哲明
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Patent Information

Application Number
CN202411409342.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-10
Publication Date
2025-01-03

AI Technical Summary

Technical Problem

The existing alcohol-resistant medicine has a single mechanism of action, limited functional coverage, and obvious side effects. It cannot fully solve the health problems of alcohol on the liver and eyes, and cannot effectively accelerate alcohol metabolism, resulting in the inability to completely eliminate the harm of alcohol to the body.

Method used

Using DYG selenium protein with high organic selenium rate (>99%) as the core component, combined with traditional Chinese medicine formula for sucking wine and nourishing liver and eye protection, high-efficiency enzyme preparations, essential vitamins, trace elements and smart wearable devices to build gradient composite formula products and health The management system realizes multi-level and personalized alcohol health management through intelligent enzymatic hangover, natural herbs and nutritional compound recipes, and long-term nourishment and intelligent nutrition regulation.

Benefits of technology

Significantly accelerate alcohol metabolism, reduce liver burden, provide comprehensive eye protection and liver protection, reduce alcohol damage to the body, achieve rapid alcohol relief, long-term nourishment, improve overall health level, and provide personalized health management solutions.

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Abstract

The invention discloses an intelligent DYG selenoprotein liver nourishing, eye protecting and hangover alleviating gradient composite formula product and an intelligent wearable equipment health management system. DYG selenoprotein, dehydrogenase, pueraria flower refreshing soup, curcumin, lalang grass rhizome, allicin, vitamins and the like are compounded into a fast, medium and slow (long-acting) gradient liver nourishing, eye protecting and hangover alleviating formula, the liver nourishing, eye protecting and hangover alleviating formula has excellent oxidation resistance, detoxification and alcohol metabolism acceleration capabilities, can efficiently decompose alcohol, shorten drunkenness time and relieve discomfort after drinking, and eye protecting components are specially added to relieve eye fatigue. According to the invention, people drinking wine can supplement selenium for a long time, nourish liver and protect eyes into a normal state, and maintain overall health. The intelligent wearable device provides personalized health management, monitors physiological indexes in real time and pushes a customized alcohol dissolving scheme. The intelligent patch is small in design, portable and convenient to use. The comprehensive and personalized drinking health management requirements of users are met, long-term health of drinkers is concerned, and upgrading of the health industry is promoted. The invention has far-reaching social influence, wide market potential and remarkable social benefit, and aims to realize the goal of'smooth drinking without burden and health companion with each other '. The health of a drinker is taken as a core, the physical condition in the drinking process is deeply concerned, and unprecedented health experience is brought to the drinker. The invention aims at solving the global alcohol health chronic disease hidden behind the wine culture from the source by scientific and technological wisdom.
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Description

Technical Field

[0001] The present invention relates to a product with liver-nourishing, eye-protecting and hangover-relieving functions and a preparation method thereof, covering beverages as well as different dosage forms such as tablets and capsules, belonging to the technical field of food, beverages and medical health care, specifically a selenoprotein liver-nourishing, eye-protecting and hangover-relieving gradient composite formula product and a smart wearable device health management system. Background Art

[0002] The development and application of alcohol remedies is an important direction to deal with the harm of alcohol. However, alcohol remedies cannot completely eliminate alcohol damage, but can only alleviate symptoms and assist physical recovery to a certain extent. Therefore, while using alcohol remedies reasonably, it is still necessary to advocate moderate drinking and a healthy lifestyle.

[0006] In the digital age, vision problems have attracted much attention. Excessive alcohol intake can interfere with vitamin A metabolism, affect retinal function, and lead to vision loss, night blindness and other eye problems. This discovery reveals the potential threat of alcohol to eye health, especially at a time when myopia is becoming increasingly serious, and we need to be highly vigilant.

[0007] Liver care and eye protection have become the key to modern people's health management. An effective hangover solution should take into account multiple factors such as alcohol metabolism, liver protection, and vision maintenance to comprehensively solve alcohol health problems.

[0008] Most of the existing hangover-relief technologies have problems such as single mechanism of action, limited functional coverage, and obvious side effects, which cannot meet the needs of comprehensive alcohol health protection. Therefore, it is urgent to develop innovative, comprehensive and effective liver-nourishing and hangover-relief solutions.

[0009] The serious damage of alcohol to the liver and eyes has become a global public alcohol health problem. It has become an urgent need to develop safer and more effective alcohol sobering products through technological innovation to comprehensively protect people's health. Summary of the invention

[0010] The present invention is committed to using scientific and technological wisdom to crack the global alcohol health problems hidden behind the wine culture from the source, and innovatively introduces DYG selenoprotein as the core component. The DYG selenoprotein has a high organic selenium content of more than 99%, showing extraordinary antioxidant, detoxification and alcohol metabolism acceleration effects. This technical solution is not limited to the application of a single product, but deeply integrates DYG selenoprotein with traditional Chinese medicine formulas for alcohol detoxification, liver nourishment and eye protection, high-efficiency enzyme preparations (such as alcohol dehydrogenase), essential vitamins, trace elements, cutting-edge new materials and smart wearable devices to build a comprehensive and systematic alcohol health management solution.

[0011] DYG selenoprotein is a selenoprotein product with a high organic selenium rate (>99%) that is purified by high-precision dialysis. It ensures that selenium exists in an organic form with extremely high biological activity through optimized conversion technology, achieving a bioavailability of more than 95% or even 100% without any side effects. As a scientifically formulated, safe and efficient dietary selenium supplement, it not only meets the basic needs of the human body for selenium, but also exhibits a variety of secondary health benefits. Studies have shown that DYG selenoprotein can effectively promote the liver's detoxification function and accelerate alcohol metabolism, thereby protecting the liver and reducing alcohol damage to the liver. It is an ideal hangover auxiliary product. In addition, its powerful antioxidant properties help to resist free radical damage, maintain cell health, and further support overall health and well-being. DYG selenoprotein is not only an excellent selenium supplement, but also an all-round health partner that promotes liver health and enhances the body's defense capabilities.

[0012] Accelerated alcohol metabolism: DYG selenoprotein uses the selenium element as a cofactor to significantly enhance the activity of alcohol dehydrogenase (ADH) and promote the rapid conversion of ethanol to acetaldehyde. At the same time, it indirectly activates acetaldehyde dehydrogenase (ALDH) and accelerates the decomposition of acetaldehyde to acetic acid, thereby effectively shortening the retention time of alcohol in the body and reducing the burden on the liver.

[0013] Antioxidant defense: Alcohol metabolism is accompanied by the generation of a large number of free radicals. DYG selenoprotein, with its excellent antioxidant capacity, can promptly remove these free radicals and protect liver cells and systemic tissues from oxidative stress damage.

[0014] Detoxification and protection: DYG selenoprotein not only accelerates the excretion of alcohol and its metabolites, but also has a wide range of detoxification functions, helping to maintain the health of organs such as the liver and eyes.

[0015] Synergy with alcohol detoxification drugs: DYG selenoprotein works together with traditional alcohol detoxification drugs such as alcohol dehydrogenase to form a powerful metabolic acceleration effect. It not only directly catalyzes the decomposition of alcohol, but also promotes the efficient operation of the metabolic chain by enhancing enzyme activity, achieving double acceleration.

[0016] Comprehensive health management: Combining essential vitamins, trace elements and cutting-edge new materials, DYG selenoprotein not only solves the problem of alcohol metabolism, but also comprehensively improves the level of physical health; the integration of smart wearable devices provides the possibility for personalized health management, real-time monitoring of the impact of alcohol, and timely adjustment of intervention strategies.

[0017] The present invention innovatively combines DYG selenoprotein with a variety of alcohol sobering, liver nourishing, eye protection ingredients and modern scientific and technological means to form a systematic and comprehensive alcohol health management solution, aiming to fundamentally solve global alcohol health problems, promote rapid alcohol metabolism, strengthen liver protection, and improve the overall health level of individuals. The introduction of this comprehensive technical solution marks an important step in addressing alcohol health challenges and provides a scientific, efficient and comprehensive solution to alcohol health problems worldwide.

[0018] Technical solution of the present invention A smart DYG selenoprotein liver-nourishing, eye-protecting and alcohol-relieving gradient compound formula product and a smart wearable device health management system, the characteristics of which include: 1. Smart health management system and solution module, smart wearable device and patch module, smart DYG selenoprotein liver-nourishing, eye-protecting and hangover-relieving gradient compound formula module, product module, preparation process module

[0019] 2. Smart health management system and solution module 1. Gradient liver care, eye protection, hangover relief, smart health management program 1.1 Overview of the solution: This solution is based on the human metabolic mechanism, biology, nutrition principles and intelligent technology to build a comprehensive, multi-level and personalized gradient hangover, liver and eye protection intelligent health management system. By accurately regulating the hangover speed and maintenance effect at different stages, combined with intelligent monitoring and feedback, efficient, safe and comprehensive alcohol health management can be achieved. 1.2 Intelligent diagnosis and evaluation system: Biometrics and health records: Using advanced biometrics technology, combined with basic user information, personal health records can be quickly established and updated to achieve long-term tracking and analysis of health data. Multi-dimensional health data analysis: Integrate wearable devices, mobile health applications and user self-reported data, including physiological indicators, living habits, environmental factors, etc., to conduct multi-dimensional and in-depth health data analysis. AI-assisted diagnosis and risk assessment: Use advanced machine learning algorithms to conduct in-depth mining of users' health data, identify potential health risks, and provide personalized health advice and warnings. 1.3 Gradient liver and eye protection hangover strategy First echelon: Instant response intelligent enzymatic alcohol detoxification and liver protection module, core ingredients and technologies: DYG selenoprotein, alcohol dehydrogenase, acetaldehyde dehydrogenase, coenzyme NAD+ and high-efficiency catalyst, combined with intelligent enzyme activity regulation technology, automatically adjust the enzyme release amount according to the individual's alcohol intake. Innovation: Introducing intelligent microcapsule technology to achieve fixed-point and timed release of enzymes, improving the efficiency and safety of alcohol detoxification. Second echelon: Medium-speed conditioning natural herbal and nutritional compound formula, core ingredients: DYG selenoprotein, optimized version of kudzu flower decoction, D flavonoids, curcumin, eye protection essence and compound nutrients. Innovative technology: Nano-encapsulation and sustained-release technology are used to improve the bioavailability of herbal ingredients and nutrients, ensuring a continuous and stable liver-nourishing and eye-protecting effect. Personalized adjustment: Dynamically adjust the compound ratio according to the user's health data and living habits to achieve personalized and precise intervention. Third echelon: Long-term nourishing intelligent nutritional regulation system, core ingredients: DYG selenoprotein, customized compound vitamins, trace elements, Omega3 fatty acids and antioxidants. Intelligent regulation: Establish a personalized nutrition assessment model, combine the user's real-time health data and living habits, and dynamically adjust the nutrient ratio and supplement amount. Innovative application: Use 3D printing technology to customize personalized nutritional supplements and achieve precise nutritional intervention.

[0020] 1.2 Gradient liver-nourishing, eye-protecting and hangover-relief strategy framework

[0021] 1.4 Echelon relationship and action process: After drinking, the first echelon intelligent enzymatic alcohol sobering and liver protection module is immediately activated. The intelligent microcapsule technology releases enzymes and other ingredients according to the amount of alcohol intake, and quickly metabolizes alcohol under the synergistic effect of other ingredients, reducing immediate liver damage and playing an immediate alcohol sobering and liver protection role. After a period of time after drinking, the second echelon natural herbal and nutritional compound formula takes effect. Nano-encapsulation and sustained-release technology enable the ingredients to be released continuously and stably, conditioning the liver, protecting the eyes, and relieving discomfort symptoms. The personalized compound ratio accurately meets the individual's medium-speed conditioning needs. In long-term daily life, the third echelon long-term nourishing intelligent nutrition regulation system continues to operate. Through personalized nutrition assessment models combined with real-time health data and living habits, 3D printing technology is used to customize nutritional supplements to provide comprehensive and accurate nutritional support for the liver and eyes, achieving long-term nourishment and preventive health care, and DYG selenoprotein further enhances the effect. The three echelons work together to form a comprehensive, systematic, and personalized strategy to provide individuals with all-round health protection.

[0022] Tier Relationship and Health Conditioning Process after Drinking

[0023] 1.5 Dynamic monitoring and feedback system, real-time monitoring: Use wearable devices to monitor the user's alcohol metabolism, liver health indicators and eye status in real time, and realize real-time data upload and analysis. Intelligent feedback: Based on the user's real-time health data, combined with historical health records and current living environment, use advanced algorithms to dynamically adjust the hangover, liver and eye protection plan, and push personalized health advice and reminders to users through APP or smart voice assistants. Telemedicine support: Cooperate with professional medical institutions to provide online consultation, health consultation and emergency medical assistance services to ensure that users can get professional medical support in any situation.

[0024] 1.6 Health management services and community interaction, health management services: provide users with comprehensive health management services, including health record management, health risk assessment, personalized health plan formulation and implementation supervision, etc. Health education and prevention: regularly push health education content to users to improve their health awareness and self-management ability. At the same time, provide personalized disease prevention strategies and suggestions based on the user's health status and living habits. Community interaction and incentive mechanism: establish a user community to encourage users to share experiences, insights and achievements, and encourage and support each other. Set up health challenge tasks and reward mechanisms to stimulate users' enthusiasm and initiative to participate. This gradient hangover, liver and eye protection intelligent health management program deeply integrates scientific ideas, intelligent technology and personalized services to achieve full coverage from immediate hangover to long-term maintenance. It not only improves the personalization, accuracy and user experience of the program, but also enhances the user's sense of participation and enthusiasm, which helps to form good healthy living habits and long-term health benefits.

[0025] The mechanism of action and synergistic effect of DYG selenoproteins and each echelon Intelligent enzymatic alcohol detoxification and liver protection module (first echelon) Upregulating the activity of alcohol metabolism enzymes: DYG selenoprotein can upregulate the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase in the liver, and may play a role at the level of gene transcription or post-translational modification, such as binding to enzyme gene promoters to promote transcription, modifying enzyme proteins to change conformation and activity, accelerating alcohol metabolism, reducing the residence time and toxic effects of alcohol and its metabolites in the body, and reducing the metabolic burden on the liver. Antioxidant effect: Selenium is an important component of antioxidant enzymes such as glutathione peroxidase. DYG selenoprotein participates in the synthesis of antioxidant enzymes, increases the activity of antioxidant enzymes in liver cells, removes free radicals produced by alcohol metabolism, reduces oxidative stress levels, protects liver cells from free radical attack and damage, maintains intracellular redox balance, and reduces alcohol-induced liver inflammation and cell apoptosis.

[0026] Natural Herbal and Nutritional Compounds (Second Tier) Enhance the efficacy of natural herbal ingredients: synergize with D-flavonoids and curcumin to resist oxidation, activate the intracellular antioxidant signaling pathway, increase the activity of the antioxidant enzyme system, remove free radicals, and reduce liver inflammation; work with curcumin to regulate liver metabolism, promote the discharge of harmful substances, and maintain a healthy liver environment; interact with the optimized version of the ingredients of the kudzu flower decoction to regulate the circulation of qi and blood in the liver and the metabolism of water, and enhance the effect of hangover and liver protection. Support for nutrient modules: synergize with lutein, zeaxanthin, etc. in the eye protection essence to protect retinal cells, reduce the accumulation of free radicals, prevent oxidative damage, and protect vision; maintain the activity of vitamins in the complex nutrients to better play their role in liver metabolism and eye protection. Adapt to personalized needs: According to the specific situation of the user, synergize with liver protection or eye protection ingredients to accurately regulate users with poor liver function or a history of eye diseases; work together with ingredients with antioxidant and biological clock regulating effects to reduce the damage to the body caused by staying up late.

[0027] Long-lasting nourishment - Intelligent nutrition regulation system (third echelon) Enhance immunity: activate the activity of cells in the human immune system, such as T lymphocytes, B lymphocytes and macrophages, promote the proliferation, differentiation and activity enhancement of immune cells, improve the body's immune defense capabilities, and provide overall immune protection for the liver and eyes. Antioxidation and cell protection: participate in the synthesis of antioxidant enzymes such as glutathione peroxidase, continue to play an antioxidant role, remove free radicals in the body, reduce the damage of oxidative stress to cells, and protect liver cells and retinal cells. Promote liver metabolism and detoxification: participate in the activity regulation of various metabolic enzymes in the liver, promote liver material metabolism and energy metabolism, improve metabolic efficiency, enhance detoxification function, promote the discharge of harmful substances, and reduce the burden on the liver. Maintain eye health: In addition to antioxidant effects, it may participate in the synthesis and metabolism of important proteins in the eyes, maintain the normal structure and physiological function of the eyes, prevent cataracts, and regulate the function of retinal photoreceptor cells. Intelligent regulation and personalized customization: Participate in personalized nutritional assessment and consider the user's needs for selenoprotein; coordinate intelligent regulation to work with other nutrients to adjust the nutrient ratio and supplement amount according to the user's real-time health data and living habits; use 3D printing technology to customize personalized nutritional supplements and accurately add DYG selenoprotein to meet the user's personalized needs.

[0028] The first echelon: The intelligent enzymatic alcohol sobering and liver protection module is activated immediately after drinking, with the rapid metabolism of alcohol as the main goal. DYG selenoprotein enhances the activity of alcohol metabolism enzymes, speeds up alcohol metabolism, and reduces immediate liver damage; the intelligent microcapsule technology realizes the precise release and action of enzymes from a physical level, and DYG selenoprotein provides additional protection from a biochemical level, protecting the liver on multiple levels.

[0029] The second echelon: The natural herbal and nutritional compound formula exerts a medium-speed conditioning effect within a period of time after drinking. The addition of DYG selenoprotein makes the conditioning effect more comprehensive and lasting, and works together with the natural herbal ingredients and nutrient modules to provide comprehensive support in terms of anti-oxidation, anti-inflammation, liver metabolism regulation and eye protection, thereby achieving continuous liver and eye protection effects. In the adjustment of personalized compound ratios, DYG selenoprotein works together with other ingredients according to the user's different health data and living habits to achieve precise personalized conditioning.

[0030] The third echelon: long-term nourishment - the intelligent nutrition regulation system provides comprehensive and precise nutrition support for the liver and eyes in long-term daily life, achieving long-term nourishment and preventive health care. DYG selenoprotein works synergistically with customized complex vitamins, trace elements, Omega-3 fatty acids, antioxidants, etc. to form a comprehensive nutrition support system; the intelligent regulation and innovative application characteristics are closely combined with the role of DYG selenoprotein to achieve intelligent personalized health management and provide individuals with all-round health protection.

[0031] 3. Smart wearable devices and patch technology solutions This program introduces a number of innovative technologies to provide an efficient, safe and personalized solution for hangover.

[0032] 1. Alcohol sensor technology Smart wearable devices integrate advanced biosensors that can accurately monitor the alcohol concentration in the user's body in real time based on principles such as electrochemistry, optics or gas chromatography. The alcohol content in both the blood and the skin surface can be detected quickly and accurately. When the alcohol concentration exceeds the preset safety threshold, the device's built-in intelligent algorithm will immediately trigger a response mechanism, providing a key basis for subsequent hangover measures.

[0033] 2. Thermal Activation Technology In order to improve the efficiency of hangover treatment, the smart wearable device uses a unique thermal activation technology. On the one hand, the device has a built-in micro-heating element. When the alcohol concentration is detected to be excessive, the drug patch attached to the skin will be heated with precise temperature control. The selected alcohol dehydrogenase and acetaldehyde dehydrogenase have high thermal stability and can show higher enzyme activity in a specific temperature range (usually slightly above body temperature), thereby accelerating the decomposition process of alcohol. On the other hand, thermal activation technology can also promote skin microcirculation and further increase the absorption rate of drugs. This innovative technology provides strong support for hangover treatment, making the hangover process more efficient.

[0034] 3. Pulse technology Smart wearable devices also introduce pulse technology to achieve non-invasive, painless and efficient drug delivery. When the alcohol concentration is detected to exceed the preset safety threshold, the micro-alcohol sensing pulse switch activates the built-in micro-pulse generator to provide precise pulse signals and pulse energy. These pulse energies can form tiny channels on the skin or temporarily increase skin permeability, providing a path for alcohol-detoxifying drugs or other active ingredients to enter the skin. For example, through pulse technologies such as ultrasound and electroporation, the absorption of drugs is effectively promoted and the efficiency of alcohol detoxification is improved.

[0035] 4. Drug patch design and innovation Formula optimization: As a carrier of hangover drugs, the design of drug patches fully considers effectiveness and safety. In addition to highly heat-stable alcohol dehydrogenase and acetaldehyde dehydrogenase, the patches also contain transdermal enhancers, stabilizers and moisturizing ingredients. Transdermal enhancers can promote the effective penetration of drugs through the skin barrier and enter the blood circulation; stabilizers ensure the stability of drugs; moisturizing ingredients improve the comfort of use. For specific groups, such as frequent drinkers, the formula will be further optimized to meet their special needs for hangover efficiency and safety.

[0036] Application of nanotechnology: Nano-crystal introduction device: uses nano-chips to open skin channels and introduce the active ingredients in the patch into the deep layers of the skin, significantly improving the absorption effect.

[0037] Electrospinning technology: Prepare nanofiber membranes to provide the skin with a moist environment that promotes health, while enhancing the fit between the patch and the skin and promoting absorption.

[0038] Electromagnetic microneedle technology: Combining microneedle and electromagnetic microflow technology, it stimulates the regeneration of collagen and elastin in the deep layers of the skin, while promoting better absorption of the active ingredients in the patch by the skin.

[0039] Bioluminescence therapy: Uses specific wavelengths of light to activate skin cells, promote skin regeneration and repair, and may help the active ingredients in the patch work better.

[0040] Intelligent and personalized patch development: Customize the patch formula and ingredient ratio according to the specific needs and skin conditions of consumers to achieve the best effect. At the same time, use intelligent technology to monitor skin conditions and adjust the frequency and dosage of patches.

[0041] (V) Temperature Control Release and Safety Considerations Smart wearable devices achieve slow and continuous release of drugs through precise temperature control. This not only helps improve the efficiency of hangover treatment, but also reduces the side effects that may be caused by the sudden and large-scale release of drugs. The device has an overheating protection mechanism to ensure that the heating process will not cause burns or other safety hazards to the user. For example, when the temperature exceeds the safe range, the device will automatically stop heating to ensure the safety of the user.

[0042] (VI) Selection and innovation of auxiliary materials Variety combination and dosage range: Gelatin adhesive (5% - 10%): provides good skin adhesion. Sodium alginate (3% - 7%): adhesive, increases the stability and moisturizing properties of the patch. Menthol (1% - 3%): transdermal absorption enhancer, brings a cool feeling and improves the use experience. Propylene glycol (5% - 10%): transdermal absorption enhancer, increases drug solubility. Hyaluronic acid (hyaluronic acid, 1% - 3%): moisturizer, forms a moisturizing and breathable film to keep the skin moisturized. Urea (1% - 2%): stratum corneum softener, promotes drug absorption.

[0043] Reasons for selection: Gelatin and sodium alginate are used as adhesives to ensure that the patch fits tightly to the skin and improve the stability and durability of the drug. Gelatin has good biocompatibility and degradability, and is suitable as a matrix material for the patch. Sodium alginate can increase the elasticity and moisturizing properties of the patch and improve the comfort of use. Menthol, as a transdermal absorption enhancer, increases skin permeability, promotes better penetration of drug ingredients into the deep layers of the skin, and brings a cool feeling to improve the user experience. Propylene glycol, as a transdermal absorption enhancer and solvent, effectively increases the solubility of the drug, promotes the diffusion and absorption of drug ingredients on the skin, and also has a moisturizing effect. Hyaluronic acid, as a moisturizer, forms a moisturizing and breathable film on the skin surface, effectively locks in moisture, prevents skin dryness, promotes the metabolism and repair of skin cells, and improves the skin care effect of the patch. Urea, as a stratum corneum softener, softens and removes the aged stratum corneum on the skin surface, promotes better penetration of drug ingredients into the deep layers of the skin, has moisturizing and antibacterial effects, and helps maintain the hygiene and stability of the patch.

[0044] (VII) Application innovation of thermosensitive materials Thermosensitive polymers: Functional properties: Using its unique "switch performance" for patch drug controlled release systems and in vivo alcohol depth monitoring. Patches containing hangover-detoxifying ingredients can automatically adjust the release of hangover-detoxifying drugs through the rise and fall of alcohol concentration in the body.

[0045] Mechanism of action: When the patch is attached to the skin, the thermosensitive polymer undergoes a phase change or swelling due to the skin temperature, thereby increasing the permeability and skin absorption of the drug.

[0046] Safety: Generally has good biocompatibility and non-toxicity, suitable for use in patches.

[0047] .Thermosensitive liposomes: Functional characteristics: Tiny vesicles composed of lipid molecules that can encapsulate drug molecules. At a specific temperature, the liposome membrane undergoes a phase change, thereby releasing the drug.

[0048] Mechanism of action: When the patch is attached to the skin and reaches a specific temperature, the thermosensitive liposome membrane undergoes a phase change, resulting in rapid release of the drug and penetration into the skin.

[0049] Safety: As a drug carrier, it usually has good biocompatibility and non-toxicity, and is easily absorbed by the skin.

[0050] Thermoresponsive nanomaterials: Functional properties: Nanomaterials that can change size, shape or surface properties in response to changes in temperature.

[0051] Mechanism of Action: In patches, thermoresponsive nanomaterials can change their permeability as skin temperature changes, thereby increasing skin absorption of drugs.

[0052] Safety: Good biocompatibility and non-toxicity can be ensured during design and synthesis.

[0053] The smart wearable device hangover solution is based on a deep understanding of the alcohol metabolism mechanism and integrates a number of innovative technologies and multidisciplinary knowledge. Through precise monitoring of alcohol concentration, intelligent trigger response mechanism, controlled drug release, and consideration of individual differences and safety, an efficient, safe, personalized and comfortable hangover solution is created.

[0054] During the alcohol metabolism process, the device accurately grasps the body's natural metabolic pathway for alcohol, uses innovative technologies to accelerate the activity of key enzymes, and improves the efficiency of hangover. Individual differences and customized services fully consider the differences among different users in terms of alcohol metabolism ability, drug reactivity, and skin characteristics, providing users with personalized hangover effects. In terms of safety and supervision, strict safety tests and clinical trials ensure the safety and effectiveness of the products, while complying with relevant laws and regulations and regulatory requirements to provide users with reliable protection. User education and feedback mechanisms help users use the equipment correctly, while continuously optimizing products and services to enhance user experience.

[0055] In short, this smart wearable device and patch technology solution provides new ideas and methods for hangover relief through the application of innovative technologies, meeting the market demand for personalized health management.

[0056] Smart wearable device alcohol concentration monitoring and hangover assistance technology solution Device Overview: This solution aims to design a smart wearable device (such as a bracelet) that integrates alcohol concentration monitoring, intelligent response and heat-activated hangover relief. The device monitors the alcohol concentration in the user's body in real time. When it detects that the alcohol concentration exceeds the standard, it automatically activates the heating element to promote the activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in the drug patch, accelerates the decomposition of alcohol, and thus improves the efficiency of hangover relief.

[0057] Technical Solution Hardware design: Biosensor: integrated electrochemical or optical alcohol sensor to monitor the alcohol concentration of the user's blood or skin surface in real time. Micro-heating element: built-in micro-heating element with precise temperature control, used to heat the drug patch. Drug patch: design drug patch containing highly thermally stable ADH and ALDH, transdermal enhancer, stabilizer and moisturizing ingredients. Intelligent processor: equipped with high-performance microprocessor, running intelligent algorithm, processing sensor data, controlling heating element, and adjusting hangover strategy according to user information. Display and interaction: configure a small display screen to display information such as alcohol concentration and hangover progress, and support touch or voice interaction. 2. Software design: Real-time monitoring and data analysis: develop real-time monitoring algorithm, analyze sensor data, and accurately determine the user's alcohol concentration. Intelligent response mechanism: when the alcohol concentration exceeds the preset threshold, the heating element and drug release are automatically triggered. Personalized hangover solution: adjust the formula and heating parameters of the drug patch according to the personal information entered by the user (such as age, gender, weight, drinking habits, etc.). Safety monitoring: implement overheating protection mechanism to ensure that the heating process is safe and harmless. User education and feedback system: Provides tutorials, alcohol concentration interpretation and hangover effect evaluation, and collects user feedback to optimize services. Advanced technology integration, nanotechnology: Uses nano-nano crystal introduction instrument and electrostatic spinning technology to improve the absorption effect and fit of drug patches. Electromagnetic microneedle technology: Combines microneedle and electromagnetic microfluidic technology to promote the absorption of drug ingredients deep in the skin. Bioluminescence therapy: Uses specific wavelengths of light to activate skin cell vitality and assist drugs in taking effect.

[0058] Pharmacokinetics and pharmacodynamics optimization. Transdermal technology: optimize the lipid solubility, molecular size and shape of drug patches to promote passive diffusion. Precise temperature control: precise control of heating temperature through intelligent algorithms to ensure maximum enzyme activity without inactivation. Efficacy evaluation: continuous monitoring of hangover effects, adjustment of drug release rate and heating parameters.

[0059] Safety and regulation. Electrical safety and heating element safety: Comply with relevant electrical safety standards to ensure that the heating element has no safety hazards under normal use. Skin irritation testing of drug patches: Conduct rigorous skin irritation tests to ensure that the patches are safe and non-irritating to most users. Clinical trials and regulatory compliance: Conduct clinical trials to verify the hangover effect and safety, and ensure that the product complies with relevant laws and regulations. User education and feedback. Usage tutorial: Provide detailed equipment usage tutorials and precautions. Alcohol concentration interpretation: Help users understand alcohol concentration data and its significance. Alcohol sobering effect evaluation: Regularly evaluate the hangover sobering effect and provide personalized adjustment suggestions. User feedback collection: Establish a user feedback mechanism to continuously optimize products and services.

[0060] Implementation steps: Hardware development and testing: Complete the design and testing of biosensors, heating elements, drug patches and intelligent processors. Software development and debugging: Develop software functions such as real-time monitoring, intelligent response, personalized hangover solutions and safety monitoring. Advanced technology integration and testing: Integrate nanotechnology, electromagnetic microneedle technology and bioluminescence therapy into products and conduct comprehensive testing. Clinical trials and safety assessments: Conduct clinical trials to verify the hangover effect and safety and ensure that the product complies with regulations and regulatory requirements. User education and marketing promotion: Provide user education materials, conduct marketing promotion and collect user feedback.

[0061] Expected results: Through the design and implementation of this solution, an efficient, safe, personalized and comfortable smart wearable device will be developed for alcohol concentration monitoring and assisting in hangover relief. The device will meet the market demand for personalized health management and provide users with a scientific, convenient and effective hangover relief service.

[0062] Gradient liver-nourishing, eye-protecting, and hangover-relief formula and technical solution. The present invention adopts a gradient liver-nourishing, eye-protecting, and hangover-relief network system, which consists of the following three echelons: The first echelon: an instant response intelligent enzymatic hangover-relief and liver-protection module, core ingredients and technologies: DYG selenoprotein, alcohol dehydrogenase, acetaldehyde dehydrogenase, coenzyme NAD+ and high-efficiency catalyst, combined with intelligent enzyme activity regulation technology, automatically adjusts the enzyme release amount according to the individual's alcohol intake, responsible for rapid hangover and liver protection; The second echelon: a medium-speed conditioning natural herbal and nutritional compound formula, core ingredients: DYG selenoprotein kudzu flower awakening soup optimized version, D flavonoids, curcumin, eye protection essence and compound nutrients, responsible for medium-speed hangover, liver-nourishing and eye-protection; Innovative technology: using nano-encapsulation and sustained-release technology to improve the bioavailability of herbal ingredients and nutrients, and ensure a sustained and stable liver-nourishing and eye-protecting effect. The third echelon: long-term nourishing intelligent nutrition regulation system, core ingredients: DYG selenoprotein, customized complex vitamins, trace elements, Omega3 fatty acids and antioxidants, responsible for slow hangover, liver and eye protection; intelligent regulation: establish a personalized nutrition assessment model, combine the user's real-time health data and living habits, and dynamically adjust the nutrient ratio and supplement amount.

[0063] 4. Smart DYG selenoprotein liver-nourishing, eye-protecting and alcohol-relieving gradient compound formula module Beverage formula and preferred ratio (weight percentage, the same below): DYG selenoprotein 3%-5%, alcohol dehydrogenase 2%-3%, acetaldehyde dehydrogenase 1.5%-2.5%, coenzyme NAD+ 1%-2%, D flavonoids 0.5%-1.5%, curcumin 0.3%-0.7%, chitosan 3%-5%, kudzu flower wake-up soup extract 12%-18%, complex vitamins 0.5%-1.5%, complex trace elements 1%-2%, Imperata root extract 3%-9%, honey 2%-5%, sodium citrate 0.2%-0.4%; preferred ratio: DYG selenoprotein 4%, alcohol dehydrogenase 2.5%, acetaldehyde dehydrogenase 2%, coenzyme NAD+ 1.5%, D flavonoids 1%, curcumin 0.5%, chitosan 5%, kudzu flower wake-up soup extract 15%, complex vitamins 1%, complex trace elements 1.5%, Imperata root extract 6%, honey 3%, sodium citrate 0.3%; Patch formula and preferred ratio: DYG selenoprotein 20%-30%, alcohol dehydrogenase 10%-20%, alcohol dealdehydease 10%-15%, coenzyme NAD+ 5%-10%, zinc 0.5%-3%, curcumin 1%-3%, chitosan 10%-30%, garlic seed powder 5%-15%, multivitamins 5%-15%, kudzu flower Jiexing decoction extract 25%-30%, pharmaceutical excipients 10%-15%; gelatin 5%-10%, sodium alginate 3%-7%, menthol 1%-3%, propylene glycol 5%-10%, hyaluronic acid (hyaluronic acid) 1%-3%, urea 1%-2%, thermosensitive polymer 5%-15% / thermosensitive liposome 5%-10% / thermoresponsive nanomaterials 8%-18%. Preferred ratio: DYG selenoprotein 25% Alcohol dehydrogenase: 15% Alcohol dealdehydease: 12.5% ​​Coenzyme NAD+: 7.5% Zinc: 1.75% Curcumin: 2% Multivitamins: 10% Pueraria lobata extract: 27.5% Pharmaceutical excipients (total): 12.5% ​​- Gelatin: 7.5% - Sodium alginate: 5% - Menthol: 2% - Propylene glycol: 7.5% - Hyaluronic acid (hyaluronic acid): 2% - Urea: 1.5% Thermosensitive materials (total): 31% - Thermosensitive polymers: 10% - Thermosensitive liposomes: 7.5% - Thermoresponsive nanomaterials: 13.5% Tablet formula: DYG selenoprotein 25%, alcohol dehydrogenase 15%, alcohol dealdehydease 12%, coenzyme NAD+ 8%, kudzu flower Jiexing decoction extract 28%, chitosan 5%, garlic seed powder 5%, pharmaceutical excipients 12% (including microcrystalline cellulose 4%, hydroxypropyl methylcellulose 3%, cross-linked sodium carboxymethyl cellulose 3%, magnesium stearate 1%, silicon dioxide 1%); Capsule formula: DYG selenoprotein 20%, alcohol dehydrogenase 13%, alcohol dealdehydease 10%, coenzyme NAD+ 8%, kudzu flower Jiexing decoction extract 30%, chitosan 5%, garlic seed powder 5%, pharmaceutical excipients 19% (including gelatin capsule shell 10%, magnesium stearate 3%, microcrystalline cellulose 3%, cross-linked sodium carboxymethyl cellulose 3%); Formula ingredients and efficacy DYG selenoprotein: DYG selenoprotein can upregulate the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase in the liver. It is a powerful antioxidant that protects liver cells from free radical damage and promotes liver detoxification function. It works at the gene transcription level or post-translational modification level by interacting with the gene expression regulatory mechanism of these enzymes. Pueraria lobata decoction extract: It is composed of Chinese medicinal materials such as Pueraria lobata, costusroot, and Amomum villosum. It has the effects of decomposing alcohol toxins, invigorating the spleen and stomach, etc.; complex vitamins: including vitamin C, Ve, and B vitamins (Vb1, Vb6, Vb12), which fully participate in liver metabolism and promote liver cell repair; complex trace elements: including zinc protein, chromium protein, and magnesium, which participate in the alcohol metabolism process and assist in protecting the liver; alcohol dehydrogenase and acetaldehyde dehydrogenase: catalyze the conversion of ethanol into acetaldehyde, and then convert acetaldehyde into acetic acid, accelerating alcohol metabolism; coenzyme NAD+: promotes the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase, and increases the rate of alcohol metabolism; D flavonoids and curcumin : Natural antioxidant, synergistically enhances the liver's antioxidant capacity and protects liver cells; Imperata root extract: Adds pleasant sweetness, its heat-clearing and diuretic effect can accelerate alcohol metabolism and excretion, its cooling blood and hemostasis, clearing lung and stomach heat can relieve the discomfort of drunkenness, and synergistically with other ingredients, it can enhance the hangover effect and provide effective relief for drunkards; Honey: Accelerates alcohol metabolism, relieves drunkenness symptoms, promotes diuresis and detoxification, provides energy support, and synergistically enhances the hangover effect, showing significant hangover effects; Chitosan: Adsorption: Chitosan has a strong adsorption capacity, which is mainly due to the free amino groups in its molecules. These amino groups can form complexes with alcohol molecules, thereby effectively wrapping up alcohol and preventing it from being absorbed by the liver. This adsorption not only reduces the amount of alcohol absorbed in the body, but also reduces the damage of alcohol to the liver and nervous system. Promote alcohol metabolism: The presence of chitosan in the body may also promote the metabolic process of alcohol. Although the specific metabolic mechanism has not yet been fully clarified, studies have shown that chitosan may accelerate the decomposition and excretion of alcohol by affecting the enzyme system in the liver. Protect the liver: Chitosan can form a protective film covering the surface of the liver, reducing the direct damage of alcohol to the liver. At the same time, chitosan also has certain antioxidant and anti-inflammatory effects, which helps to reduce the liver inflammation caused by alcohol. Garlic seed powder: Antioxidant effect: Garlic seed powder is rich in antioxidant ingredients, which can remove free radicals in the body and reduce the oxidative stress caused by alcohol. Oxidative stress is one of the important ways that alcohol damages the liver and other organs, so the antioxidant effect of garlic seed powder helps protect the liver and other organs from alcohol damage. Promote alcohol metabolism: Certain ingredients in garlic seed powder may be able to affect the enzyme system in the liver, especially enzymes related to alcohol metabolism, such as alcohol dehydrogenase and acetaldehyde dehydrogenase. These enzymes play a key role in the decomposition and metabolism of alcohol. Garlic seed powder may accelerate the metabolism and excretion of alcohol by promoting the activity of these enzymes.Anti-inflammatory effect: Alcohol intake can cause inflammatory reactions in the liver and other organs, and garlic seed powder has anti-inflammatory effects, which can reduce these inflammatory reactions, thereby protecting the liver and other organs from alcohol damage. Enhance liver function: Certain ingredients in garlic seed powder may be able to enhance the liver's detoxification ability and promote the liver's metabolism and excretion of alcohol. At the same time, it can also protect liver cells from alcohol damage and maintain the normal function of the liver. Sodium citrate: Adjust the taste and pH value to ensure product stability and palatability.

[0064] 5. Product Module a) Smart wearable device products: characterized in that the smart wearable device products are electronic devices that can be worn on different parts of the human body, including but not limited to bracelets, watches, pocket watches (a small clock worn on the chest), anklets, waist rings, neck rings, gloves, shoes, socks, hats, hand accessories (such as rings, bracelets, etc.) and clothing wearable devices (such as smart clothes, smart backpacks, etc.); b) Patch products: characterized in that the patch products are products that are directly attached to the human skin to deliver drugs or health care ingredients, including but not limited to hand patches, abdominal patches, head patches, back patches, foot patches and patches suitable for other parts of the human body (such as shoulders, knees, etc.); c) Beverage products: characterized in that the beverage products are liquid products for direct drinking by people, including but not limited to water drinks (such as mineral water, purified water), tea drinks (such as green tea, black tea, oolong tea, etc.), functional drinks (such as sports drinks, energy drinks), nutritional drinks (such as vitamin drinks, mineral drinks), milk drinks (such as pure milk, flavored milk), protein drinks (such as soy milk, plant protein drinks) and drinks suitable for nourishing the liver and sobering up (such as sobering up tea, sobering up liquid, etc.); d) Food and drug products: characterized in that the food and drug products include two major categories: food and drug, specifically covering tablets (such as vitamin tablets, mineral tablets, etc.), capsules (such as soft capsules, hard capsules, etc.), solid beverages (such as instant coffee, protein powder, milk powder, soy milk powder, tea powder, etc.), oral liquids (such as oral solutions, oral suspensions, etc.), sprays (such as nasal sprays, oral sprays, etc.), chewing gum and other forms of products. Such products are mainly used to supplement the nutrients needed by the human body, regulate physiological functions or treat diseases while sobering up; Note: The above classification and feature descriptions are intended to clarify the scope and characteristics of each product category. The possibility of adding new products or refining existing product categories in the future based on market demand and technological development is not excluded.

[0065] 6. Preparation process and method module Beverage preparation process, including: raw material selection and pretreatment - precise blending control - efficient homogenization and refinement - ultra-high temperature instantaneous sterilization technology - aseptic filling and sealing process: Beverage preparation process A: During the pretreatment of raw materials, the kudzu flower awakening soup adopts an advanced extraction technology combining ultrasonic extraction and supercritical CO2 extraction. The fineness after crushing is increased to 200 mesh, and key raw materials such as DYG selenoprotein pass through a 120-mesh sieve; the efficient blending strategy is to dissolve sodium citrate in distilled water, add all pretreated raw materials at one time, control the temperature of the mixed solution to 75±5℃, and keep warm for 15 minutes; the homogenization pressure is set to 25MPa, and high-temperature instant sterilization at 118℃ is used for 8 minutes; filling is carried out under a sterile environment, using PET bottles or sterile aluminum foil bags, combined with nitrogen filling technology; Beverage preparation process B: When pre-treating raw materials, modern extraction technology (such as ultrasonic extraction or supercritical CO2 extraction) is used to replace traditional processing methods for the kudzu flower soup for awakening. After crushing, the raw materials are sieved through a 100-mesh sieve, and other raw materials (DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD + and vitamins) are uniformly sieved through an 80-mesh sieve; when preparing, sodium citrate is dissolved in distilled water, and the kudzu flower soup for awakening extract and other raw materials are added in sequence, and the mixed solution is heated to 70-80℃ for 15-20 minutes; the homogenization pressure is adjusted to 25MPa, the homogenization times are 1, and a high-efficiency homogenizer is used; the sterilization temperature is adjusted to 115-120℃, the sterilization time is 10 minutes, and high-temperature instantaneous sterilization technology is used; filling is carried out under strict aseptic conditions, and packaging materials that meet food safety standards are selected (such as PET bottles or sterile aluminum foil bags); Tablet preparation process, including: raw material selection and pretreatment - kudzu flower decoction extraction and mixed granulation - drying and granulation optimization - tableting parameter optimization and online monitoring - optional coating process optimization: Tablet preparation process A: In the innovation of raw material pretreatment, Gehua Jiexing Decoction adopts ultrasonic + microwave dual-mode extraction, combined with vacuum drying to obtain extract powder, and all raw materials pass through a 200-mesh sieve; fluidized bed one-step granulation is adopted, combined with vacuum drying and microwave-assisted drying; tableting parameters are customized according to the characteristics of raw materials, and sustained-release film coating is adopted; Tablet preparation process B: During the pretreatment of raw materials, modern extraction technology (such as ultrasonic extraction, microwave extraction or supercritical CO2 extraction) is used to replace the traditional water decoction method for Gehua Jiexing Decoction. After concentration, spray drying or vacuum drying is used to obtain the extract powder. The raw materials (DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD +, etc.) are uniformly passed through a 100-mesh sieve, and the pharmaceutical excipients are processed in advance; a one-step granulation method (such as fluidized bed granulation) is used to optimize the mixing conditions; vacuum drying or microwave drying is used, and the granules are passed through a 20-mesh sieve after being granulated; the tablet press parameters are adjusted according to the raw material characteristics and tablet requirements, and online monitoring equipment is introduced; suitable coating materials are selected according to the tablet characteristics and requirements, and efficient coating equipment and technology are used (coating is optional); Capsule preparation process, including: unified processing of raw materials and optimization of extracts - one-step mixing and filling with online monitoring - optional automated polishing - packaging material selection and process control: Unified processing of raw materials and optimization of extracts: Capsule preparation process A: All raw materials are uniformly sieved through a 200-mesh sieve during unified processing of raw materials and optimization of extracts. Ultrasonic and microwave extraction is used for the Gehua Jiexing Decoction, and spray drying is used to obtain a stable extract. A high-efficiency mixing and filling machine is used to achieve integration of raw material mixing and capsule filling, with real-time monitoring. Automated polishing equipment is used to ensure the smooth surface of the capsules, and aluminum-plastic blister packaging or sealed bottles are used. Capsule preparation process B: During the raw material pretreatment, all raw materials (including kudzu flower jiexing decoction extract, DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD +, etc.) are uniformly sieved through a 100-mesh sieve. The kudzu flower jiexing decoction extract uses modern extraction technology to improve the extraction efficiency, and vacuum drying or spray drying is used to obtain a stable extract powder; an integrated device with mixing and filling functions is used, and online monitoring equipment is introduced to ensure consistent quality; automated polishing equipment is used (optional); appropriate packaging materials (such as aluminum-plastic blister packaging, bottle packaging, etc.) are selected according to product characteristics and needs, the packaging environment is strictly controlled, and a packaging form with good sealing performance is used; The patch preparation process includes: precise weighing and quality inspection of raw materials - preparation of uniform gelatinous matrix - slow addition and homogenization of active ingredients - molding and drying - cutting, sealing and quality inspection: Patch preparation process C: Raw material preparation: according to the patch formula, accurately weigh the active ingredients such as DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD+, zinc, curcumin, multivitamins, kudzu flower Jiexing decoction extract, and pharmaceutical excipients such as gelatin, sodium alginate, menthol, propylene glycol, hyaluronic acid, urea, thermosensitive polymers (or thermosensitive liposomes, thermoresponsive nanomaterials). Inspect the raw materials to ensure that their quality meets the requirements, and the purity and activity of the active ingredients should meet the specified standards; Matrix preparation: Add gelatin and sodium alginate to an appropriate amount of distilled water, stir and dissolve at a certain temperature (e.g. 50 - 60°C) to form a uniform gelatinous matrix. Then, add menthol, propylene glycol, hyaluronic acid (hyaluronic acid), urea, etc. to the matrix in sequence, continue to stir evenly, and mix all the ingredients thoroughly; Addition of active ingredients: Slowly add DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD + and other active ingredients into the above matrix, stirring while adding to ensure that the active ingredients are evenly dispersed. For thermosensitive polymers (or thermosensitive liposomes, thermoresponsive nanomaterials), add them using appropriate methods according to their characteristics, such as encapsulating thermosensitive liposomes through microencapsulation technology and then adding them to the matrix to ensure their stability and effectiveness; Mixing and homogenization: Add the remaining ingredients such as curcumin, multivitamins, and kudzu flower extract to the mixture, stir evenly, and then use a homogenizer to homogenize the material to make it more delicate and uniform, thereby improving the quality of the patch. The homogenization pressure can be set to 15-20MPa, and the number of homogenizations can be 2-3 times; Molding and drying: Pour the homogenized material into a mold to form a uniform sheet, then dry it at an appropriate temperature (such as 40-50°C) and humidity to remove moisture and obtain a preliminarily formed patch. The drying time depends on the thickness of the patch and the drying conditions, and is generally 12-24 hours; Cutting and packaging: Cut the dried patch into the specified size and then package it with sealed packaging materials to prevent the patch from being contaminated and affected by moisture. The packaged patch should be inspected for quality, including appearance inspection, drug content determination, viscosity test, etc., to ensure that the patch meets the quality standards; Patch preparation process D: Raw material pretreatment: Micronize active ingredients such as DYG selenoprotein to a certain particle size requirement (such as less than 10 μm) to improve their dispersibility and bioavailability. The extract of Gehua Jiexing Decoction is refined using advanced extraction technology (such as supercritical fluid extraction combined with macroporous resin adsorption) to increase the content and purity of active ingredients. Grind and sieve pharmaceutical excipients such as gelatin and sodium alginate to make their particle size uniform; Solution preparation: Dissolve gelatin and sodium alginate in an appropriate amount of distilled water, heat to a certain temperature (such as 40-50°C), stir evenly to form a glue solution. Then dissolve propylene glycol, menthol, urea, etc. in an appropriate amount of water, add them to the glue solution, continue to stir evenly, disperse the thermosensitive polymer (or thermosensitive liposome, thermoresponsive nanomaterial) in a specific solvent, use ultrasonic treatment or high-speed stirring to make it evenly dispersed, and then slowly add it to the above mixed solution; Active ingredient mixing: Add DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD+, zinc, curcumin, multivitamins, kudzu flower Jiexing decoction extract and other active ingredients to the above solution in a certain order, stirring while adding to ensure that the active ingredients are evenly dispersed. A combination of low-speed stirring and ultrasonic-assisted dispersion can be used to improve the mixing effect; Degassing and coating: Degas the mixed solution to remove bubbles in it to prevent bubbles from affecting the quality during the patch molding process. Then evenly coat the solution on the pre-prepared backing material, and the coating thickness should be uniform. An automatic coating machine can be used for coating operations to control the coating speed and thickness; Drying and curing: Dry the patch coated with drug solution at a certain temperature (such as 30-40℃) and humidity conditions to allow the solvent to evaporate gradually, and the drug and excipients to form a solid patch. For patches containing heat-sensitive materials, the temperature should be controlled according to the characteristics of the heat-sensitive materials during the drying process to achieve an appropriate curing state. The drying time depends on the thickness of the patch and the drying conditions, and is generally 8-16 hours; Cutting and packaging: Cut the dried and solidified patch into the specified size, apply the anti-sticking layer, and then seal and package. The packaging material should have good barrier properties to prevent the patch from being affected by the external environment. Perform quality inspection on the packaged patch, including the inspection of appearance, content, viscosity, release rate and other indicators to ensure that the quality of the patch meets the requirements; The preparation process of smart wearable devices includes: precise weighing and quality inspection of raw materials - preparation of uniform colloidal matrix - slow addition and homogenization of active ingredients - molding and drying - cutting, sealing and quality inspection: Overall design and component selection 1. Biosensor selection and integration: Select highly sensitive and accurate electrochemical or optical alcohol sensors to ensure real-time monitoring of the user's alcohol concentration. The sensor needs to be miniaturized so that it can be embedded in wearable devices while maintaining good biocompatibility and stability. 2. Micro alcohol sensing electronic switch and pulse generator: Design a micro alcohol sensing electronic switch that matches the sensor to ensure rapid response when the alcohol concentration exceeds the standard. Integrate a micro pulse generator to provide precise pulse signals and energy to assist drug absorption. 3. Micro heating element: Select a micro heating element with precise temperature control to ensure safe and effective heating of the drug patch. The heating element needs to be connected to an intelligent processor to achieve intelligent temperature control. 4. Intelligent processor and algorithm: Equipped with a high-performance microprocessor, it runs an intelligent algorithm to process sensor data, control the heating element and pulse generator. The algorithm needs to adjust the hangover strategy based on user information (such as weight, gender, drinking habits, etc.) to achieve a personalized hangover solution. 5. Display and interactive module: Configure a small, high-resolution display to support touch or voice interaction. The display screen must be able to clearly display information such as alcohol concentration and hangover progress for easy viewing by users; Preparation process 1. Sensor and electronic component assembly: Assemble and weld the selected biosensors, micro alcohol sensing electronic switches, micro heating elements, micro pulse generators and other electronic components; Ensure that the connection between the components is reliable and there is no short circuit or open circuit; 2. Intelligent processor and software burning: Connect the high-performance microprocessor with the assembled electronic components; Burn the intelligent algorithm into the microprocessor to ensure that the algorithm can operate normally and process sensor data; 3. Display and interactive module integration: Connect the small display screen with the microprocessor to ensure the normal display function; Integrate touch or voice interaction modules to facilitate user interaction with the device; 4. Device shell design and manufacturing: Design an ergonomic device shell to ensure that it is comfortable to wear and easy to operate; Use suitable materials (such as silicone, plastic, etc.) to manufacture the shell, and perform waterproof and dustproof treatment; 5. Assembly and testing: Install the assembled electronic components, intelligent processor, display screen and other components into the shell; Conduct comprehensive functional tests to ensure that the equipment can work normally and meet the design requirements; 6. Calibration and debugging: Calibrate the alcohol concentration monitoring function of the device to ensure the accuracy of the measurement results; Adjust the intelligent algorithm and the temperature control strategy of the heating element according to the test results to optimize the hangover effect; 7. Packaging and factory inspection: Package the equipment and attach accessories such as instruction manual and warranty card; conduct factory inspection to ensure that each device meets quality standards and meets user needs; Quality control and after-sales service, establish a strict quality control system, monitor and inspect every link in the production process; provide comprehensive after-sales service to promptly resolve problems encountered by users during use; regularly maintain and upgrade the equipment to ensure that the equipment always maintains optimal performance.

[0066] Beneficial effects of the present invention: The present invention discloses a smart DYG selenoprotein liver-nourishing, eye-protecting and alcohol-detoxifying gradient composite formula product and a smart wearable device health management system, which is committed to using scientific and technological wisdom to crack the global alcohol health problems hidden behind the wine culture from the source. Through the combination of the smart DYG selenoprotein liver-nourishing, eye-protecting and alcohol-detoxifying gradient composite formula product and the smart wearable device health management system, a scientific, efficient and systematic solution and path are provided for global alcohol health issues. The high-precision purified DYG selenoprotein not only has excellent antioxidant, detoxifying and alcohol metabolism acceleration capabilities, but also promotes the long-term repair and regeneration of liver cells through deep optimization of the ratio and activity, effectively preventing alcoholic liver disease. Its unique gradient composite formula can quickly decompose alcohol and its metabolites, significantly shorten the drunken state, reduce discomfort after drinking, and reduce alcohol absorption and protect the gastric mucosa. In addition, the specially added eye protection ingredients effectively relieve eye fatigue, resist blue light damage, and protect vision health. The integration of smart wearable devices realizes personalized health management, real-time monitoring of physiological indicators, and pushes customized alcohol detoxification solutions, which greatly improves the accuracy of health management and user experience. The smart patch is compact and portable, and can be used immediately after application, avoiding gastrointestinal irritation and improving the convenience and comfort of use. The successful implementation of the present invention not only provides users with a comprehensive and personalized alcohol health management solution, but also promotes the upgrading of the health industry, leads the new trend of scientific and technological health preservation, has far-reaching social impact and huge market potential, and truly realizes the beautiful vision of "drinking without burden, and being always healthy". It has significant social benefits and broad application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0067] Figure 1 It shows a schematic diagram of the thinking logic and technical solution architecture structure provided according to a specific embodiment of the present invention; Figure 2 A schematic diagram of a scientific principle and a technical logic structure provided according to a specific embodiment of the present invention is shown; Figure 3 The scientific principle diagram of the DYG selenoprotein liver-nourishing, eye-protecting and hangover-relieving compound formula is shown;

[0068] The present invention will be further described below in conjunction with the embodiments. DETAILED DESCRIPTION

[0069] A smart DYG selenoprotein liver-nourishing, eye-protecting and alcohol-relieving gradient compound formula product and smart wearable device health management system The present invention relates to a health management system that integrates a smart health management system, smart wearable devices and patches, a smart DYG selenoprotein formula, a product module and a preparation process. The system is intended to provide users with all-round and personalized health management services, especially showing significant effects in sobering up, nourishing the liver and protecting the eyes.

[0070] Alcohol sobering assistance system based on smart wearable devices The core modules of this system include: Intelligent diagnosis and assessment module: Using advanced biometric technology and combining basic user information, we can establish and update personal health records in real time. By integrating multi-source health data and using machine learning algorithms for in-depth mining, we can accurately identify potential health risks and provide personalized health advice and early warning services.

[0071] Gradient liver-nourishing, eye-protecting and hangover-relief strategy module: Instant response intelligent enzymatic hangover relief: Using key enzymes such as alcohol dehydrogenase, acetaldehyde dehydrogenase and coenzyme NAD+, combined with intelligent microcapsule technology, to achieve intelligent controlled release of enzymes. When alcohol intake is detected, the intelligent microcapsule responds quickly, releasing enzymes to promote alcohol metabolism and protect the liver.

[0072] Medium-speed conditioning natural herbal and nutritional compound formula: Contains the optimized version of Kudzu flower decoction, D-flavonoids, curcumin and other natural herbal ingredients and nutrients, using nano-encapsulation technology to improve bioavailability. The compound ratio is dynamically adjusted according to the user's health data to achieve the effect of medium-speed hangover relief, liver nourishment and eye protection.

[0073] Long-term nourishment Intelligent nutrition regulation: Customize personalized multivitamin and trace element supplementation plans based on user health data and living habits. Use 3D printing technology to achieve precise delivery of personalized nutritional supplements and provide long-term nourishment support.

[0074] Dynamic monitoring and feedback module: The user's alcohol metabolism, liver health indicators and eye condition are monitored in real time through smart wearable devices, and the data is uploaded to the cloud for analysis in real time. According to the analysis results, the hangover, liver and eye protection plan is dynamically adjusted, and personalized health advice and reminders are pushed to users through the APP or smart voice assistant. At the same time, online consultation, health consultation and emergency medical assistance services with professional medical institutions are provided.

[0075] Health management service and community interaction module: Provide users with services such as health record management, health risk assessment, personalized health plan formulation and execution supervision. Regularly push health education content to improve users' health awareness and self-management ability. At the same time, establish a user community, encourage users to share health experiences, insights and achievements, set up health challenge tasks and reward mechanisms, and stimulate users' enthusiasm and initiative to participate.

[0076] Smart wearable devices and drug patches The system also includes: Smart wearable devices: integrated with high-precision biosensors (such as electrochemical or optical alcohol sensors), micro alcohol sensing electronic switches, micro heating elements, intelligent processors, display screens, and interactive modules. The device can monitor the alcohol concentration in the user's body in real time, and automatically trigger a response mechanism when the concentration exceeds a preset threshold. It uses micro heating elements to precisely control the temperature and heat the drug patch attached to the skin to promote rapid absorption of the drug. At the same time, the device supports touch or voice interaction, allowing users to view information such as alcohol concentration and hangover progress and receive personalized health advice.

[0077] Drug patch: It uses advanced transdermal absorption technology and contains multiple active ingredients such as DYG selenoprotein, alcohol dehydrogenase, and pharmaceutical excipients such as gelatin and sodium alginate. The patch uses smart microcapsule technology and nano-encapsulation technology to achieve efficient and stable drug release. At the same time, the patch also has an intelligent controlled release function, which can automatically adjust the drug release amount according to the user's alcohol intake and health status.

[0078] Software design: including multiple sub-modules such as real-time monitoring algorithm, intelligent response mechanism, personalized hangover solution, safety monitoring, and user education and feedback system. Intelligent algorithms are used to process sensor data and control heating elements and pulse generators to achieve personalized hangover relief services; at the same time, user feedback is collected to optimize the service experience.

[0079] Integration of advanced technologies: Advanced technologies such as integrated nanotechnology, electromagnetic microneedle technology and bioluminescence therapy further improve the absorption effect of drug patches and the user's hangover experience.

[0080] Pharmacokinetics and pharmacodynamics optimization: Ensure the best hangover-relieving effect by optimizing the transdermal technology, precise temperature control and efficacy evaluation of drug patches; at the same time, continuously adjust the optimization strategy based on user feedback and actual results.

[0081] Gradient hangover relief, liver health and eye protection program This program adopts a gradient strategy to achieve a comprehensive, multi-level effect of sobering up, nourishing the liver and protecting the eyes: The first echelon: alcohol dehydrogenase, acetaldehyde dehydrogenase and coenzyme NAD+ are the core ingredients responsible for rapid alcohol sobering and liver protection; The second echelon: contains the optimized version of Kudzu Flower Decoction, D-flavonoids, curcumin and other natural herbal ingredients and nutrients responsible for moderately rapid hangover relief, liver health and eye protection; The third echelon: It is composed of nutrients such as complex vitamins and trace elements, which are responsible for slowly sobering up, nourishing the liver and protecting the eyes.

[0082] The specific formula is as follows (weight percentage): Drink formula: DYG selenoprotein 4%, alcohol dehydrogenase 2.5%, acetaldehyde dehydrogenase 2%, coenzyme NAD+1.5%, D-flavonoids 1%, curcumin 0.5%, chitosan 5%, kudzu flower awakening soup extract 15%, multivitamins 1%, multi-trace elements 1.5%, Imperata root extract 6%, honey 3%, sodium citrate 0.3%; Patch formula: DYG selenoprotein 25%, alcohol dehydrogenase 15%, alcohol dealdehydease 12.5%, coenzyme NAD+ 7.5%, zinc 1.75%, curcumin 2%, multivitamins 10%, kudzu flower Jiexing decoction extract 27.5%, pharmaceutical excipients 12.5% ​​(including gelatin 7.5%, sodium alginate 5%), thermosensitive materials 31% (including thermosensitive polymer 10%, thermosensitive liposome 7.5%, thermoresponsive nanomaterials 13.5%); Tablet formula: DYG selenoprotein 25%, alcohol dehydrogenase 15%, alcohol dealdehydease 12%, coenzyme NAD+ 8%, kudzu flower Jiexing decoction extract 28%, chitosan 5%, garlic seed powder 5%, pharmaceutical excipients 12% (including microcrystalline cellulose 4%, hydroxypropyl methylcellulose 3%, cross-linked sodium carboxymethyl cellulose 3%, magnesium stearate 1%, silicon dioxide 1%); Capsule formula: DYG selenoprotein 20%, alcohol dehydrogenase 13%, alcohol dealdehydease 10%, coenzyme NAD+8%, kudzu flower Jiexing decoction extract 30%, chitosan 5%, garlic seed powder 5%, pharmaceutical excipients 19% (including gelatin capsule shell 10%, magnesium stearate 3%, microcrystalline cellulose 3%, cross-linked sodium carboxymethyl cellulose 3%).

[0083] Product Categories Smart wearable devices: including wristbands, watches and other electronic devices that can be worn on different parts of the human body; Patch products: including hand patches, abdominal patches and other products that are directly attached to human skin to deliver drugs or health care ingredients; Beverage products: including water drinks, tea drinks and other liquid products for people to drink directly; Food and drug products: including products in solid form such as tablets and capsules, and products in liquid form such as oral liquids and sprays.

[0084] Preparation process and method Beverage preparation technology Beverage preparation process A: Raw material selection and pretreatment: Select high-quality raw materials and pretreat them. The kudzu flower awakening soup is processed using advanced extraction technology combining ultrasonic extraction and supercritical CO2 extraction to improve the extraction rate and purity of the active ingredients; Precise blending control: Precisely weigh the pretreated raw materials according to the formula ratio and add an appropriate amount of distilled water for blending. Control the temperature of the mixed solution within the range of 75±5℃ and keep it warm for 15 minutes to ensure that all ingredients are fully dissolved and mixed evenly; High-efficiency homogenization and refinement: Use a high-efficiency homogenizer to homogenize the mixed liquid to refine the particles in the mixed liquid and improve the taste and stability of the drink; Ultra-high temperature instantaneous sterilization technology: The homogenized mixed liquid is sterilized by ultra-high temperature instantaneous sterilization technology to kill the microorganisms in the mixed liquid and ensure the hygiene and safety of the beverage; Aseptic filling and sealing process: Under strict aseptic conditions, the sterilized mixed liquid is filled into pre-prepared PET bottles or sterile aluminum foil bags and other packaging containers and sealed to prevent external contamination.

[0085] Beverage preparation process B: Optimization of raw material pretreatment: In addition to ultrasonic extraction and supercritical CO2 extraction technology, other suitable extraction technologies such as microwave extraction and hot reflux extraction can be selected according to the characteristics of the raw materials to improve the extraction efficiency and purity; Adjustment of blending parameters: Adjust the order of adding ingredients and mixing time according to actual needs to ensure the stability and consistency of the blending effect; at the same time, add appropriate amounts of auxiliary materials such as stabilizers and thickeners to improve the stability and taste of the beverage; Selection of homogenizing equipment: In addition to using high-efficiency homogenizers, other suitable homogenizing equipment such as colloid mills, high-pressure homogenizers, etc. can also be selected to improve the homogenization effect; Optimization of sterilization conditions: Adjust parameters such as sterilization temperature and time according to the characteristics of beverage ingredients and packaging materials to ensure the best sterilization effect while avoiding adverse effects on beverage ingredients; Packaging material selection: In addition to PET bottles and aseptic aluminum foil bags, other suitable packaging materials such as glass bottles, plastic bottles, etc. can be selected for filling and sealing according to market demand.

[0086] Tablet preparation process Tablet preparation process A: Raw material selection and pretreatment: Select high-quality raw materials and pretreat them to ensure that they meet the requirements for use. The kudzu flower awakening soup is processed using ultrasonic + microwave dual-mode extraction technology to improve the extraction rate and purity of the active ingredients; Mixing granulation: After the pre-treated raw materials are mixed evenly according to the formula ratio, the fluidized bed one-step granulation technology is used for granulation. In the granulation process, vacuum drying and microwave-assisted drying technology are combined to speed up the drying speed and ensure the uniformity and stability of the particles; Drying and granulation optimization: The granules are dried to remove residual moisture. After drying, the granules are granulated by a granulator to obtain the required granule size and shape; Tableting parameter customization: Tableting parameters such as pressure and speed are customized according to raw material characteristics and tablet requirements to ensure that the tablet hardness, disintegration, etc. meet the standards; at the same time, online monitoring equipment is introduced to monitor the tableting process in real time to ensure the stability of tablet quality; Coating process selection: Select appropriate coating materials such as sustained-release film coating materials according to the characteristics and requirements of the tablets, and use efficient coating equipment and technology to coat the tablets to improve the stability and bioavailability of the tablets.

[0087] Tablet preparation process B: Diversified raw material pretreatment: In addition to the ultrasonic + microwave dual-mode extraction technology, other suitable extraction technologies such as supercritical CO2 extraction, hot reflux extraction, etc. can be selected for processing to improve extraction efficiency and purity; Optimization of mixed granulation method: In addition to the fluidized bed one-step granulation technology, other suitable granulation methods such as wet granulation and dry granulation can be selected to ensure the uniformity and stability of the particles; at the same time, the process parameters of the granulation process can be adjusted according to actual needs to obtain the ideal particle size and shape; Selection of drying and granulating equipment: In addition to vacuum drying and granulating machines, other suitable drying equipment such as hot air drying, freeze drying, etc. can be selected to ensure the dryness and stability of the particles; Adjustment of tableting parameters: In addition to customizing tableting parameters according to raw material characteristics and tablet requirements, it is also necessary to regularly check the operating status of the tablet press and the wear of the mold to ensure the stability and reliability of the tableting effect; at the same time, the process parameters in the tableting process can be adjusted according to actual needs to obtain ideal tablet hardness and disintegration, etc. Coating process innovation: In addition to selecting appropriate coating materials and technologies for coating treatment, new coating processes such as enteric coating and gastric coating can also be explored to meet the needs of different users and improve the stability and bioavailability of tablets.

[0088] Capsule preparation process Capsule preparation process A: Unified processing of raw materials and optimization of extracts: All raw materials are uniformly screened to remove impurities and ensure the fineness and uniformity of the raw materials. The kudzu flower awakening soup is processed using ultrasonic + microwave extraction technology to improve the extraction rate and purity of the active ingredients; One-step mixing and filling: Use a high-efficiency mixing and filling machine to mix the pre-treated raw materials and excipients evenly and then fill them directly into the capsule shell. The mixing and filling process realizes the integrated operation of raw material mixing and capsule filling, and introduces online monitoring equipment to monitor the filling process in real time to ensure the stability and consistency of capsule quality; Automated polishing: Use automated polishing equipment to polish the filled capsules to remove burrs and impurities on the capsule surface to improve the appearance quality and smoothness of the capsules; Selection of packaging materials: Select packaging materials that meet the requirements, such as aluminum-plastic blister packaging, bottles, etc. to package the polished capsules. During the packaging process, strictly control the temperature, humidity and other conditions of the packaging environment to ensure the quality and stability of the capsules; at the same time, use packaging with good sealing performance to extend the shelf life of the capsules.

[0089] Capsule preparation process B: Diversified raw material pretreatment: In addition to ultrasonic + microwave extraction technology, other suitable extraction technologies such as supercritical CO2 extraction, hot reflux extraction, etc. can be selected for processing to improve extraction efficiency and purity; Selection of mixing and filling equipment: In addition to using efficient mixing and filling machines, other suitable filling equipment such as rotary filling machines, reciprocating filling machines, etc. can be selected to ensure the filling volume and sealing of the capsules; at the same time, the process parameters in the filling process can be adjusted according to actual needs to obtain the ideal filling effect; Polishing process optimization: In addition to using automated polishing equipment, other suitable polishing methods such as manual polishing, mechanical polishing, etc. can be selected according to actual needs to obtain the ideal polishing effect; at the same time, suitable polishing media and polishing time and other parameters need to be selected to ensure the consistency and stability of the polishing effect; Innovation of packaging materials: In addition to aluminum-plastic blister packaging and bottle packaging, other suitable packaging materials such as aluminum foil bags and plastic bottles can be selected according to market demand for packaging. During the packaging process, the temperature, humidity and other conditions of the packaging environment must be strictly controlled to ensure the quality and stability of the capsules; at the same time, new packaging forms such as modified atmosphere packaging and vacuum packaging can be explored to extend the shelf life of the capsules and improve the user's purchasing experience.

[0090] Patch preparation process Patch preparation process C: Precise weighing and quality inspection of raw materials: Accurately weigh each ingredient according to the patch formula and conduct quality inspection to ensure that its quality meets the requirements and the purity and activity of the active ingredients meet the specified standards; Preparation of uniform gel matrix: Add pharmaceutical excipients such as gelatin and sodium alginate into an appropriate amount of distilled water and stir and dissolve at a certain temperature to form a uniform gel matrix; then add transdermal absorption enhancers such as menthol and propylene glycol into the matrix and continue to stir evenly to improve the absorption efficiency and bioavailability of the drug; Slowly add and homogenize active ingredients: Slowly add DYG selenoprotein, alcohol dehydrogenase and other active ingredients into the matrix while stirring to ensure that the active ingredients are evenly dispersed in the matrix; For thermosensitive materials, appropriate methods should be used to add them according to their characteristics, such as encapsulating thermosensitive liposomes through microencapsulation technology and then adding them to the matrix to ensure their stability and effectiveness; After the addition is completed, use a homogenizer to homogenize the mixture to improve the uniformity and stability of the patch.

[0091] Forming and drying: Pour the homogenized material into a mold to form a uniform sheet. Dry the material under appropriate temperature and humidity conditions to remove moisture from the material and obtain a preliminarily formed patch. During the drying process, the patch needs to be turned over regularly to ensure uniform drying and prevent adhesion. The drying time depends on the thickness of the patch and the drying conditions, and is generally 12-24 hours.

[0092] Cutting, sealing and quality inspection: Cut the dried patch into the specified size and then package it with sealed packaging materials to prevent the patch from being contaminated and affected by moisture. The packaging material should have good barrier properties to ensure the stability and safety of the patch during storage and use. Perform quality inspection on the packaged patch, including appearance inspection, drug content determination, viscosity test, etc., to ensure that the patch meets the quality standards. At the same time, record the patch's batch number, production date, expiration date and other information for traceability and management.

[0093] Patch preparation process D: Raw material pretreatment and nanotechnology: Active ingredients such as DYG selenoprotein are micronized to improve their dispersibility and bioavailability. Natural herbal ingredients such as the kudzu flower decoction extract are made into nanoparticles using nanotechnology to improve their transdermal absorption efficiency and bioavailability.

[0094] Solution preparation and intelligent controlled release: Dissolve pharmaceutical excipients such as gelatin and sodium alginate in an appropriate amount of distilled water, add transdermal absorption enhancers such as menthol and propylene glycol, and stir evenly to form a gel solution. Add active ingredients such as DYG selenoprotein and alcohol dehydrogenase to the gel solution according to the formula ratio, and use intelligent controlled release technology to encapsulate them in nanoparticles or microcapsules to achieve intelligent controlled release of drugs.

[0095] Degassing and coating: Degas the prepared solution to remove bubbles in it to prevent bubbles from affecting the quality during the patch forming process. Use an automatic coating machine to evenly coat the degassed solution on the pre-prepared backing material to form a uniform coating. The coating thickness should be adjusted according to the specifications and usage requirements of the patch.

[0096] Drying and curing: The coated patch is dried under appropriate temperature and humidity conditions to allow the solvent to evaporate gradually and the drug and excipients to form a solid patch. During the drying process, parameters such as temperature and time must be controlled to avoid adverse effects on the drug ingredients. After drying, the patch is cured to improve its hardness and stability.

[0097] Cutting and packaging: Cut the cured patch into the specified size, and then apply an anti-sticking layer to prevent the patch from sticking during storage and use. Use sealed packaging materials to package the patch to prevent it from being contaminated and affected by moisture. During the packaging process, the temperature, humidity and other conditions of the packaging environment must be strictly controlled to ensure the quality and stability of the patch. Perform quality inspection on the packaged patch, including appearance inspection, drug content determination, viscosity test, etc., to ensure that the patch meets the quality standards.

[0098] Smart wearable device preparation process Overall design and component selection Biosensor: Use highly sensitive and high-precision electrochemical or optical alcohol sensors to ensure real-time monitoring of alcohol concentration, and miniaturize the design to ensure biocompatibility and stability. Microelectronic switch and pulse generator: Matching sensor, rapid response beyond threshold, integrated micro pulse generator, assisting drug absorption. Micro heating element: Precise temperature control, safe heating of drug patches, and linkage with intelligent processor. Intelligent processor and algorithm: High-performance microprocessor runs intelligent algorithm, processes data, controls heating and pulse, and realizes personalized hangover solution. Display and interaction: Small high-definition touch or voice interactive screen, clearly displaying alcohol concentration and hangover progress.

[0099] Preparation process 1. Component preparation: clean and dry electronic components, prepare core components. 2. Assembly and welding: professional welding, ensure no short circuit or open circuit, functional test. 3. Software burning: burn intelligent algorithm to microprocessor, functional test. 4. Module integration: display screen and interactive module integration, test compatibility and stability. 5. Shell design and manufacturing: ergonomic, waterproof and dustproof. 6. Assembly and testing: comprehensive functional test, check appearance and size. 7. Calibration and debugging: calibrate alcohol concentration monitoring function, optimize hangover effect. 8. Packaging and factory inspection: professional packaging, ensure transportation safety, comprehensive factory inspection. 9. Quality control and after-sales service: Quality control: formulate detailed standards, monitor production links, and establish quality traceability mechanism. After-sales service: professional team provides technical support, collects user feedback, and responds to problems quickly. Equipment maintenance: regular maintenance and upgrades, introduce new technologies, and maintain optimal performance.

Claims

1. A selenoprotein liver-nourishing, eye-protecting and alcohol-relieving gradient compound formula product and a smart wearable device health management system, characterized in that: include: Smart health management system and solution module, smart wearable device and patch module, smart DYG selenoprotein liver-nourishing, eye-protecting and alcohol-relieving gradient compound formula module, product module, and preparation process module.

2. According to claim 1, the smart health management system and solution module is characterized in that: include: Intelligent health management system A hangover assistance system based on a smart wearable device, characterized by comprising: The intelligent diagnosis and assessment module has the function of using biometric technology combined with basic user information to establish and update personal health records, integrate multi-source data for multi-dimensional health data analysis, and use machine learning algorithms to conduct in-depth mining of health data to identify potential health risks and provide personalized health advice and warnings; Gradient liver-nourishing, eye-protecting and hangover-relief strategy module, including: The instant response intelligent enzymatic alcohol sobering and liver protection submodule uses DYG selenoprotein, alcohol dehydrogenase, acetaldehyde dehydrogenase, coenzyme NAD+, high-efficiency catalyst and intelligent enzyme activity regulation technology, combined with intelligent microcapsule technology. The intelligent microcapsule interacts with alcohol molecules or their metabolites to trigger the permeability change or degradation mechanism of the shell, so that the enzyme is released in a set manner and rate. The microcapsule shell is made of biocompatible and degradable materials, and the internal environment is specially designed to maintain stable enzyme activity. This submodule automatically adjusts the enzyme release amount according to the individual's alcohol intake; The medium-speed conditioning natural herbal and nutritional compound prescription module includes DYG selenoprotein, optimized version of Kudzu Flower Awakening Soup (including Kudzu Flower, Aucklandia Sinensis, etc.), D flavonoids, curcumin, eye protection essence and compound nutrients. It uses nano-encapsulation and sustained-release technology to improve the bioavailability of herbal ingredients and nutrients, and can dynamically adjust the compound ratio according to the user's health data and living habits; The long-term nourishing intelligent nutrition regulation submodule includes customized multivitamins (including fat-soluble and water-soluble vitamins), trace elements (zinc, selenium, iron, etc.), Omega3 fatty acids, antioxidants (vitamin C, E, β-carotene, etc.) and DYG selenoprotein. It establishes a personalized nutrition assessment model, combines the user's real-time health data and living habits, dynamically adjusts the nutrient ratio and supplement amount, and uses 3D printing technology to customize personalized nutritional supplements; Dynamic monitoring and feedback module, including the use of wearable devices to monitor the user's alcohol metabolism, liver health indicators and eye status in real time and to upload and analyze data in real time. Based on the user's real-time health data, combined with historical health records and current living environment, the algorithm is used to dynamically adjust the hangover, liver and eye protection plan, and the personalized health advice and reminders are pushed to the user through the APP or smart voice assistant. In addition, the function of cooperating with professional medical institutions to provide online consultation, health consultation and emergency medical assistance services; The health management service and community interaction module includes the functions of providing users with services such as health record management, health risk assessment, personalized health plan formulation and implementation supervision, regularly pushing health education content to users, improving users' health awareness and self-management capabilities, and providing personalized disease prevention strategies and suggestions based on users' health status and living habits. It also establishes a user community, encourages users to share experiences, insights and achievements, sets health challenge tasks and reward mechanisms, and stimulates users' enthusiasm and initiative to participate.

3. The smart wearable device and patch module according to claims 1-2, characterized in that: include: Smart wearable devices and patch systems A hangover assistance system based on a smart wearable device, characterized by comprising: The smart wearable device has the function of monitoring the alcohol concentration in the user's body in real time through an integrated biosensor. When the alcohol concentration is detected to exceed a preset safety threshold, the micro alcohol sensing electronic switch activates the device's built-in intelligent algorithm to trigger a response mechanism, and uses the built-in micro heating element to accurately control the temperature and heat the drug patch attached to the skin. At the same time, the micro alcohol sensing pulse switch activates the built-in micro pulse generator to provide accurate pulse signals and pulse energy to open the skin channel, promoting the rapid absorption of alcohol detoxification drugs or other active ingredients through the skin. The biosensor is an electrochemical or optical alcohol sensor, and the micro heating element has a precise temperature control function. The smart processor is equipped with a high-performance microprocessor, which runs an intelligent algorithm to process sensor data, control the heating element, and adjust the alcohol detoxification strategy according to user information. The display screen and the interactive module are configured with a small display screen, which supports touch or voice interaction, and displays information such as alcohol concentration and alcohol detoxification progress. The drug patch contains DYG selenoprotein 20% - 30%, alcohol dehydrogenase 10% - 20%, alcohol dealdehydease 10% -15%, coenzyme NAD+ 5% - 10%, zinc 0.5% - 3%, curcumin 1% - 3%, multivitamins 5% - 15%, kudzu flower Jiexing decoction extract 25% - 30%, pharmaceutical excipients 10% - 15%, and also contains gelatin 5% - 10%, sodium alginate 3% - 7%, menthol 1% - 3%, propylene glycol 5% - 10%, hyaluronic acid (hyaluronic acid) 1% - 3%, urea 1% - 2%, thermosensitive polymer 5% - 15% / thermosensitive liposome 5% - 10% / thermoresponsive nanomaterial 8% - 18%, of which gelatin and sodium alginate are used as adhesives to ensure that the patch fits the skin tightly, improve drug stability and durability, and have good biocompatibility and degradability. Sodium alginate can also increase the elasticity and moisturizing properties of the patch. Menthol is used as a transdermal absorption enhancer to increase skin permeability and bring a cool feeling. Propylene glycol is used as a transdermal absorption enhancer and solvent to increase drug solubility and moisturize. Hyaluronic acid is used as a moisturizer to form a moisturizing and breathable film on the skin surface to promote skin cell metabolism and repair. Urea is used as a stratum corneum softener to promote drug absorption and has moisturizing and antibacterial effects. Thermosensitive polymers use their temperature-responsive characteristics to be used in patch drug controlled release systems and in vivo alcohol depth monitoring. They can automatically adjust the release of hangover drugs in the patch according to the rise and fall of alcohol concentration in the body. Thermosensitive liposomes are composed of lipid molecules. At a specific temperature, the membrane undergoes a phase change to release drugs. Thermoresponsive nanomaterials can respond to temperature changes to change permeability and increase drug skin absorption. They all have good biocompatibility and are non-toxic. Software design modules, including a functional module for developing a real-time monitoring algorithm to analyze sensor data to accurately determine the user's alcohol concentration, an intelligent response mechanism module that automatically triggers the heating element and drug release when the alcohol concentration exceeds a preset threshold, a personalized hangover solution module that adjusts the drug patch formula and heating parameters based on the user's personal information (such as age, gender, weight, drinking habits, etc.), a safety monitoring module that implements overheating protection to ensure the safety of the heating process, and a user education and feedback system module that provides usage tutorials, alcohol concentration interpretation and hangover effect evaluation, and collects user feedback to optimize services; Advanced technology integration module, including the nanotechnology module that uses nano-nano crystal introduction instrument and electrospinning technology to improve the absorption effect and fit of drug patches, the electromagnetic microneedle technology module that combines microneedle and electromagnetic microfluidic technology to promote the absorption of drug ingredients deep into the skin, and the bioluminescence therapy module that uses light of a specific wavelength to activate the vitality of skin cells to assist the drug in taking effect; The pharmacokinetic and pharmacodynamic optimization module includes a transdermal technology module that optimizes the lipid solubility, molecular size and shape of drug patches to promote passive diffusion, a precise temperature control module that uses intelligent algorithms to accurately control the heating temperature to ensure maximum enzyme activity without inactivation, and a pharmacodynamic evaluation module that continuously monitors the hangover effect and adjusts the drug release rate and heating parameters.

4. The smart DYG selenoprotein liver-nourishing, eye-protecting and alcohol-relieving gradient compound formula module according to claims 1-3 is characterized in that it comprises: Formula for nourishing liver, protecting eyes and waking up A DYG selenoprotein liver-nourishing, eye-protecting and wakefulness-relief formula combination, characterized by comprising: The beverage formula comprises (by weight percentage): DYG selenoprotein 3% - 5%, alcohol dehydrogenase 2% - 3%, acetaldehyde dehydrogenase 1.5% - 2.5%, coenzyme NAD+ 1% - 2%, D flavonoids 0.5% - 1.5%, curcumin 0.3% - 0.7%, chitosan 3%-5%, kudzu flower jiexing decoction extract 12% - 18%, complex vitamins 0.5% - 1.5%, complex trace elements 1% - 2%, Imperata root extract 3% - 9%, honey 2% - 5%, sodium citrate 0.2% - 0.4%. The preferred ratio is: DYG selenoprotein 4%, alcohol dehydrogenase 2.5%, acetaldehyde dehydrogenase 2%, coenzyme NAD+ 1.5%, D Flavonoids 1%, curcumin 0.5%, chitosan 5%, kudzu flower decoction extract 15%, complex vitamins 1%, complex trace elements 1.5%, Imperata root extract 6%, honey 3%, sodium citrate 0.3%; The patch formula contains DYG selenoprotein 20% - 30%, alcohol dehydrogenase 10% - 20%, alcohol dealdehyde enzyme 10% -15%, coenzyme NAD+ 5% - 10%, zinc 0.5% - 3%, curcumin 1% - 3%, chitosan 10% - 30%, garlic seed powder 5% - 15%, multivitamins 5% - 15%, kudzu flower Jiexing decoction extract 25% - 30%, pharmaceutical excipients 10% - 15%, and gelatin 5% - 10%, sodium alginate 3% - 7%, menthol 1% - 3%, propylene glycol 5% - 10%, hyaluronic acid (hyaluronic acid) 1% - 3%, urea 1% - 2%, thermosensitive polymer 5% - 15% / thermosensitive liposome 5% - 10% / thermoresponsive nanomaterial 8% - 18%. The preferred ratio is: DYG Selenoprotein 25%, alcohol dehydrogenase 15%, alcohol dealdolase 12.5%, coenzyme NAD+ 7.5%, zinc 1.75%, curcumin 2%, multivitamins 10%, kudzu flower Jiexing decoction extract 27.5%, pharmaceutical excipients (total) 12.5% ​​(including gelatin 7.5%, sodium alginate 5%, menthol 2%, propylene glycol 7.5%, hyaluronic acid 2%, urea 1.5%), thermosensitive materials (total) 31% (including thermosensitive polymer 10%, thermosensitive liposome 7.5%, thermoresponsive nanomaterials 13.5%); Tablet formula, including DYG selenoprotein 25%, alcohol dehydrogenase 15%, alcohol dealdehydease 12%, coenzyme NAD+ 8%, kudzu flower Jiexing decoction extract 28%, chitosan 5%, garlic seed powder 5%, pharmaceutical excipients 12% (including microcrystalline cellulose 4%, hydroxypropyl methylcellulose 3%, cross-linked carboxymethyl cellulose sodium 3%, magnesium stearate 1%, silicon dioxide 1%); The capsule formula contains DYG selenoprotein 20%, alcohol dehydrogenase 13%, alcohol dealdehydease 10%, coenzyme NAD+ 8%, kudzu flower Jiexing decoction extract 30%, chitosan 5%, garlic seed powder 5%, and pharmaceutical excipients 19% (including gelatin capsule shell 10%, magnesium stearate 3%, microcrystalline cellulose 3%, and cross-linked sodium carboxymethyl cellulose 3%).

5. The product module according to claims 1-4, characterized in that: include: a) Smart wearable devices: The smart wearable device products are electronic devices that can be worn on different parts of the human body, including but not limited to bracelets, watches, pocket watches (a small clock worn on the chest), anklets, waist rings, neck rings, gloves, shoes, socks, hats, hand accessories (such as rings, bracelets, etc.) and clothing wearable devices (such as smart clothes, smart backpacks, etc.); b) Patch products: The patch products are products that are directly attached to human skin to deliver drugs or health care ingredients, including but not limited to hand patches, abdominal patches, head patches, back patches, foot patches, and patches suitable for other parts of the human body (such as shoulders, knees, etc.); c) Beverage products: Characterized in that the beverage products are liquid products for direct drinking by people, including but not limited to water beverages (such as mineral water, purified water), tea beverages (such as green tea, black tea, oolong tea, etc.), functional beverages (such as sports drinks, energy drinks), nutritional beverages (such as vitamin beverages, mineral beverages), milk beverages (such as pure milk, flavored milk), protein beverages (such as soy milk, plant protein beverages) and beverages suitable for nourishing the liver and sobering up (such as sobering up tea, sobering up liquid, etc.); d) Food and drug products: It is characterized in that the food and drug products include two categories: food and drug, specifically including tablets (such as vitamin tablets, mineral tablets, etc.), capsules (such as soft capsules, hard capsules, etc.), solid beverages (such as instant coffee, protein powder, milk powder, soy milk powder, tea powder, etc.), oral liquids (such as oral solutions, oral suspensions, etc.), sprays (such as nasal sprays, oral sprays, etc.), chewing gum and other forms of products. Such products are mainly used to sober up while supplementing the nutrients needed by the human body, regulating physiological functions or treating diseases; Note: The above classification and feature descriptions are intended to clarify the scope and characteristics of each product category. The possibility of adding new products or refining existing product categories in the future based on market demand and technological development is not excluded.

6. The preparation process module according to claims 1-5, characterized in that: include: Preparation process A preparation process of a DYG selenoprotein liver-nourishing, eye-protecting and awakening product, characterized by comprising: Beverage preparation technology, including: Raw material selection and pretreatment - precise blending control - efficient homogenization and refinement - ultra-high temperature instantaneous sterilization technology - aseptic filling and sealing process: Beverage preparation process A: During the pretreatment of raw materials, the kudzu flower awakening soup adopts an advanced extraction technology combining ultrasonic extraction and supercritical CO2 extraction. The fineness after crushing is increased to 200 mesh, and key raw materials such as DYG selenoprotein pass through a 120-mesh sieve; the efficient blending strategy is to dissolve sodium citrate in distilled water, add all pretreated raw materials at one time, control the temperature of the mixed solution to 75±5℃, and keep warm for 15 minutes; the homogenization pressure is set to 25MPa, and high-temperature instant sterilization at 118℃ is used for 8 minutes; filling is carried out under a sterile environment, using PET bottles or sterile aluminum foil bags, combined with nitrogen filling technology; Beverage preparation process B: When pre-treating raw materials, modern extraction technology (such as ultrasonic extraction or supercritical CO2 extraction) is used to replace traditional processing methods for the kudzu flower soup for awakening. After crushing, the raw materials are sieved through a 100-mesh sieve, and other raw materials (DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD + and vitamins) are uniformly sieved through an 80-mesh sieve; when preparing, sodium citrate is dissolved in distilled water, and the kudzu flower soup for awakening extract and other raw materials are added in sequence, and the mixed solution is heated to 70-80℃ for 15-20 minutes; the homogenization pressure is adjusted to 25MPa, the homogenization times are 1, and a high-efficiency homogenizer is used; the sterilization temperature is adjusted to 115-120℃, the sterilization time is 10 minutes, and high-temperature instantaneous sterilization technology is used; filling is carried out under strict aseptic conditions, and packaging materials that meet food safety standards are selected (such as PET bottles or sterile aluminum foil bags); Tablet preparation process, including: Raw material selection and pretreatment - Gehua Jiexing Decoction extraction and mixed granulation - Drying and granulation optimization - Tablet compression parameter optimization and online monitoring - Optional coating process optimization: Tablet preparation process A: In the innovation of raw material pretreatment, Gehua Jiexing Decoction adopts ultrasonic + microwave dual-mode extraction, combined with vacuum drying to obtain extract powder, and all raw materials pass through a 200-mesh sieve; fluidized bed one-step granulation is adopted, combined with vacuum drying and microwave-assisted drying; tableting parameters are customized according to the characteristics of raw materials, and sustained-release film coating is adopted; Tablet preparation process B: During the pretreatment of raw materials, modern extraction technology (such as ultrasonic extraction, microwave extraction or supercritical CO2 extraction) is used to replace the traditional water decoction method for Gehua Jiexing Decoction. After concentration, spray drying or vacuum drying is used to obtain the extract powder. The raw materials (DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD +, etc.) are uniformly passed through a 100-mesh sieve, and the pharmaceutical excipients are processed in advance; a one-step granulation method (such as fluidized bed granulation) is used to optimize the mixing conditions; vacuum drying or microwave drying is used, and the granules are passed through a 20-mesh sieve after being granulated; the tablet press parameters are adjusted according to the raw material characteristics and tablet requirements, and online monitoring equipment is introduced; suitable coating materials are selected according to the tablet characteristics and requirements, and efficient coating equipment and technology are used (coating is optional); The capsule preparation process comprises: Unified processing of raw materials and optimization of extracts - one-step mixing and filling with online monitoring - optional automated polishing - packaging material selection and process control: Unified processing of raw materials and optimization of extracts: Capsule preparation process A: All raw materials are uniformly sieved through a 200-mesh sieve during unified processing of raw materials and optimization of extracts. Ultrasonic and microwave extraction is used for the Gehua Jiexing Decoction, and spray drying is used to obtain a stable extract. A high-efficiency mixing and filling machine is used to achieve integration of raw material mixing and capsule filling, with real-time monitoring. Automated polishing equipment is used to ensure the smooth surface of the capsules, and aluminum-plastic blister packaging or sealed bottles are used. Capsule preparation process B: During the raw material pretreatment, all raw materials (including kudzu flower jiexing decoction extract, DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD +, etc.) are uniformly sieved through a 100-mesh sieve. The kudzu flower jiexing decoction extract uses modern extraction technology to improve the extraction efficiency, and vacuum drying or spray drying is used to obtain a stable extract powder; an integrated device with mixing and filling functions is used, and online monitoring equipment is introduced to ensure consistent quality; automated polishing equipment is used (optional); appropriate packaging materials (such as aluminum-plastic blister packaging, bottle packaging, etc.) are selected according to product characteristics and needs, the packaging environment is strictly controlled, and a packaging form with good sealing performance is used; The patch preparation process comprises: Precise weighing and quality inspection of raw materials - preparation of uniform gelatinous matrix - slow addition and homogenization of active ingredients - molding and drying - cutting, sealing and quality inspection: Patch preparation process C: Raw material preparation: According to the patch formula, accurately weigh the active ingredients such as DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD+, zinc, curcumin, multivitamins, kudzu flower Jiexing decoction extract, as well as gelatin, sodium alginate, menthol, propylene glycol, hyaluronic acid (hyaluronic acid), urea, thermosensitive polymers (or thermosensitive liposomes, thermoresponsive nanomaterials), etc. Inspect raw materials to ensure that their quality meets the requirements and the purity and activity of active ingredients meet the specified standards; Matrix Preparation: Add gelatin and sodium alginate to an appropriate amount of distilled water, stir and dissolve at a certain temperature (e.g. 50 - 60°C) to form a uniform gelatinous matrix. Then, add menthol, propylene glycol, hyaluronic acid (hyaluronic acid), urea, etc. to the matrix in sequence, continue to stir evenly, and mix all the ingredients thoroughly; Addition of active ingredients: Slowly add DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD + and other active ingredients into the above matrix, stirring while adding to ensure that the active ingredients are evenly dispersed. For thermosensitive polymers (or thermosensitive liposomes, thermoresponsive nanomaterials), add them using appropriate methods according to their characteristics, such as encapsulating thermosensitive liposomes through microencapsulation technology and then adding them to the matrix to ensure their stability and effectiveness; Mixing and homogenization: Add the remaining ingredients such as curcumin, multivitamins, and kudzu flower extract to the mixture, stir evenly, and then use a homogenizer to homogenize the material to make it more delicate and uniform, thereby improving the quality of the patch. The homogenization pressure can be set to 15-20MPa, and the number of homogenizations can be 2-3 times; Molding and drying: Pour the homogenized material into a mold to form a uniform sheet, then dry it at an appropriate temperature (such as 40-50°C) and humidity to remove moisture and obtain a preliminarily formed patch. The drying time depends on the thickness of the patch and the drying conditions, and is generally 12-24 hours; Cutting and packaging: Cut the dried patch into the specified size and then package it with sealed packaging materials to prevent the patch from being contaminated and affected by moisture. The packaged patch should be inspected for quality, including appearance inspection, drug content determination, viscosity test, etc., to ensure that the patch meets the quality standards; Patch preparation process D: Raw material pretreatment: Micronize active ingredients such as DYG selenoprotein to a certain particle size requirement (such as less than 10 μm) to improve their dispersibility and bioavailability. The extract of Gehua Jiexing Decoction is refined using advanced extraction technology (such as supercritical fluid extraction combined with macroporous resin adsorption) to increase the content and purity of active ingredients. Grind and sieve pharmaceutical excipients such as gelatin and sodium alginate to make their particle size uniform; Solution preparation: Dissolve gelatin and sodium alginate in an appropriate amount of distilled water, heat to a certain temperature (such as 40 - 50°C), stir evenly to form a glue solution. Then dissolve propylene glycol, menthol, urea, etc. in an appropriate amount of water, add them to the glue solution, continue to stir evenly, disperse the thermosensitive polymer (or thermosensitive liposome, thermoresponsive nanomaterial) in a specific solvent, use ultrasonic treatment or high-speed stirring to make it evenly dispersed, and then slowly add it to the above mixed solution; Active ingredient mixing: Add DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD+, zinc, curcumin, multivitamins, kudzu flower Jiexing decoction extract and other active ingredients to the above solution in a certain order, stirring while adding to ensure that the active ingredients are evenly dispersed. A combination of low-speed stirring and ultrasonic-assisted dispersion can be used to improve the mixing effect; Degassing and coating: Degas the mixed solution to remove bubbles in it to prevent bubbles from affecting the quality during the patch molding process. Then evenly coat the solution on the pre-prepared backing material, and the coating thickness should be uniform. An automatic coating machine can be used for coating operations to control the coating speed and thickness; Drying and curing: Dry the patch coated with drug solution at a certain temperature (such as 30-40℃) and humidity conditions to allow the solvent to evaporate gradually, and the drug and excipients to form a solid patch. For patches containing heat-sensitive materials, the temperature should be controlled according to the characteristics of the heat-sensitive materials during the drying process to achieve an appropriate curing state. The drying time depends on the thickness of the patch and the drying conditions, and is generally 8-16 hours; Cutting and packaging: Cut the dried and solidified patch into the specified size, apply a non-stick layer, and then seal and package. The packaging material should have good barrier properties to prevent the patch from being affected by the external environment. The packaged patch should be inspected for quality, including appearance, content, viscosity, release rate and other indicators to ensure that the patch quality meets the requirements; The preparation process of smart wearable devices includes: Precise weighing and quality inspection of raw materials - preparation of uniform gelatinous matrix - slow addition and homogenization of active ingredients - molding and drying - cutting, sealing and quality inspection: Overall design and component selection 1. Biosensor selection and integration: Use highly sensitive and accurate electrochemical or optical alcohol sensors to ensure real-time monitoring of the alcohol concentration in the user's body; The sensor needs to be miniaturized so that it can be embedded in wearable devices while maintaining good biocompatibility and stability; 2. Miniature alcohol sensing electronic switch and pulse generator; Design a miniature alcohol-sensing electronic switch that matches the sensor to ensure a quick response when the alcohol concentration exceeds the standard; Integrated micro-pulse generator to provide precise pulse signals and energy to assist drug absorption; 3. Micro heating element: Use micro-heating elements with precise temperature control to ensure safe and effective heating of drug patches; The heating element needs to be connected to the intelligent processor to achieve intelligent temperature control; 4. Intelligent processor and algorithm: Equipped with a high-performance microprocessor that runs intelligent algorithms to process sensor data, control heating elements and pulse generators; The algorithm needs to adjust the hangover strategy based on user information (such as weight, gender, drinking habits, etc.) to achieve a personalized hangover solution; 5. Display screen and interactive module: Equipped with a small, high-resolution display that supports touch or voice interaction; The display screen must be able to clearly display information such as alcohol concentration and hangover progress for easy viewing by users; Preparation process 1. Sensor and electronic components assembly: Assemble and solder selected electronic components such as biosensors, micro alcohol sensing electronic switches, micro heating elements, micro pulse generators, etc.; Ensure that the connection between components is reliable and there is no short circuit or open circuit; 2. Intelligent processor and software burning: Connect high-performance microprocessors to assembled electronic components; Burn the intelligent algorithm into the microprocessor to ensure that the algorithm can run normally and process sensor data 3. Integration of display screen and interactive module: Connect the small display screen to the microprocessor to ensure that the display functions properly; Integrate touch or voice interaction modules to facilitate user interaction with the device; 4. Equipment casing design and manufacturing: Design the device housing in accordance with ergonomic principles to ensure comfortable wearing and easy operation; Use appropriate materials (such as silicone, plastic, etc.) to make the shell, and make it waterproof and dustproof; 5. Assembly and testing: Install the assembled electronic components, intelligent processors, display screens and other parts into the housing; Conduct comprehensive functional testing to ensure that the equipment can work properly and meet the design requirements; 6. Calibration and debugging: Calibrate the alcohol concentration monitoring function of the device to ensure the accuracy of the measurement results; Adjust the intelligent algorithm and the temperature control strategy of the heating element according to the test results to optimize the hangover effect; 7. Packaging and factory inspection: Pack the equipment and attach accessories such as instruction manual and warranty card; Conduct factory inspection to ensure that each device meets quality standards and meets user needs; Quality Control and After-Sales Service Establish a strict quality control system to monitor and inspect every link in the production process; Provide comprehensive after-sales service and promptly solve problems encountered by users during use; Regularly maintain and upgrade the equipment to ensure that it always maintains optimal performance.

7. In each of the claims according to claims 1-6, the functions and interrelationships of each system and module, the specific efficacy of each component and the specific functions, principles and mechanisms of each component have been described in detail in the invention content of the specification and are not listed repeatedly in the claims, but constitute an indispensable part of the present invention.

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