Method for preparing lanthanum carbonate by reacting supercritical carbon dioxide and lanthanum oxide

Abstract

The invention discloses a method for preparing lanthanum carbonate by reacting supercritical carbon dioxide and lanthanum oxide, which comprises the following steps: filling 50-99.999 wt% lanthanum oxide rare-earth raw material which has passed a 10-200-mesh sieve into an extraction kettle of a supercritical carbon dioxide extraction instrument, and reacting for 1-24 hours to obtain the lanthanum carbonate in the extraction kettle, wherein in the reaction process, the temperature of the extraction kettle is controlled at 32-100 DEG C, the pressure is 7.5-50 MPa, and the carbon dioxide with the mass percent of higher than 99.5% is subjected to forced circulation. The method is simple to operate, and has the advantages of no byproduct, low cost, high product purity and no environmental pollution. The lanthanum carbonate is a novel medicine for treating hyperphosphatemia, and has wide market prospects.

Description

technical field [0001] The invention relates to a preparation method of lanthanum carbonate, in particular to a process for preparing lanthanum carbonate by reacting supercritical carbon dioxide and lanthanum oxide. Background technique [0002] With the gradual decline of renal function and phosphorus excretion in patients with end-stage renal disease, hyperphosphatemia often occurs, and hyperphosphatemia can lead to serious complications, such as renal bone disease, hyperparathyroidism, etc. And it is positively correlated with the morbidity and mortality of cardiovascular disease in hemodialysis patients. [0003] Oral phosphate binders are currently an effective method for treating hyperphosphatemia. Lanthanum carbonate is a new type of phosphorus binder that does not contain aluminum and calcium, which has been developed in recent years and is already in the clinical application stage. The trivalent cation lanthanum contained in it has a high affinity with phosphorus, ...

AI Technical Summary

Problems solved by technology

[0004] At present, the preparation methods of lanthanum carbonate mainly include urea reflux method, ammonium bicarbonate precipitation method, sodium carbonate and lanthanum chloride reaction method and sodium bicarbonate and lanthanum chloride reaction method, etc., but these methods all need to go through multi-step chemical reactions, There are many steps, troublesome operation, many by-products, and high cost. Therefore, it is necessary to develop a new preparation method for lanthanum carbonate to meet the needs of the pharmaceutical industry for lanthanum carbonate.