High-affinity shrimp shell calcium powder, preparation method thereof and application of high-affinity shrimp shell calcium powder in preparation of medicine for treating calcium deficiency symptoms and/or diseases

A technology of shrimp shell calcium powder and affinity, applied in the field of medicine, can solve the problems of shrimp shell calcium hardness, limited addition, affecting application, etc., and achieves the effect of high calcium content and improved taste

Active Publication Date: 2021-06-15
JIANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the shells of crayfish are mostly simply processed into animal feed, and a few are used to extract and prepare chitin, which is a serious waste of resources.
The difficulty in the development of shrimp shells as calcium resources lies in two aspects. On the one hand, the calcium content of shrimp shells is relatively hard. After processing them into calcium powder, it is difficult to apply them in the food industry due to taste problems; on the other hand, shrimp shells are rich in calcium. Components such as calcium and chitin have poor compatibility with proteins, starches, polysaccharides, etc. When preparing dosage forms with protein, starch, polysaccharides, etc. as the base material, the addition amount is limited, which affects its application

Method used

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  • High-affinity shrimp shell calcium powder, preparation method thereof and application of high-affinity shrimp shell calcium powder in preparation of medicine for treating calcium deficiency symptoms and/or diseases
  • High-affinity shrimp shell calcium powder, preparation method thereof and application of high-affinity shrimp shell calcium powder in preparation of medicine for treating calcium deficiency symptoms and/or diseases
  • High-affinity shrimp shell calcium powder, preparation method thereof and application of high-affinity shrimp shell calcium powder in preparation of medicine for treating calcium deficiency symptoms and/or diseases

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preparation example Construction

[0033] In a third aspect, the present invention provides a method for preparing high-affinity shrimp shell calcium powder with a core-shell structure, the method comprising: preparing a surface modifier into a surface modifier solution, and then treating the shrimp shell calcium powder with Boiling granulation to obtain the high-affinity shrimp shell calcium powder;

[0034] Wherein, the surface modifier is composed of maltodextrin, pregelatinized starch, konjac powder, sodium carboxymethylcellulose and xanthan gum.

[0035] Through the preparation method provided by the invention, the high-affinity shrimp shell calcium powder with a core-shell structure with the shrimp shell calcium powder as the core and a surface modifier as the shell can be obtained.

[0036] According to the present invention, the amount of the surface modifier can be changed within a wide range, in order to further improve the affinity of the high-affinity shrimp shell calcium powder to protein, starch, ...

Embodiment approach

[0048] According to a preferred embodiment of the present invention, the acid treatment method comprises: acid treatment of the shrimp shells in an acetic acid solution with a concentration of 0.1-0.5% by weight, wherein the solid-liquid ratio of the shrimp shells to the acetic acid solution is 1: 5-10.

[0049] According to the present invention, in order to further improve the quality of the prepared high-affinity shrimp shell calcium powder, preferably, the acid treatment is carried out under ultrasonic conditions.

[0050] Wherein, the conditions of the ultrasound can be changed in a wide range, preferably, the power of the ultrasound is 0.4-0.6 W / cm2 (for example, it can be 0.4 W / cm2, 0.45 W / cm2, 0.5 watts / square centimeter, 0.55 watts / square centimeter, 0.6 watts / square centimeter, wherein, the area is the bottom area of ​​the container), and the ultrasonic time is 1-1.5 hours (for example, it can be 1 hour, 1.1 hours, 1.2 hours, 1.3 hours, 1.4 hours, 1.5 hours).

[00...

Embodiment 1-3

[0079] Used to illustrate the preparation method of high affinity calcium powder

[0080] According to the conditions shown in Table 1, the following operations were performed.

[0081] 1) Acid treatment: select the shell of fresh crayfish (ie, Procambarus clarkii) and perform ultrasonic treatment in an acetic acid solution.

[0082] 2) Drying and crushing: Drying the acid-treated shrimp shells with hot air, and then crushing them with a pulverizer to obtain coarse shrimp shell calcium powder.

[0083] 3) Softening: Mix the coarse shrimp shell calcium powder with water, and cook in a pressure cooker.

[0084] 4) Refinement: Add water to the softened material (using the softened material as the material, and the additional water as the liquid), use a colloid mill to pulverize, and then filter with a filter cloth, and take the filtrate and use a homogenizer to homogenize quality twice.

[0085] 5) Spray drying: the thinned material is dried in a spray drying tower, and then p...

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Abstract

The invention relates to the field of medicines, in particular to high-affinity shrimp shell calcium powder, a preparation method thereof and application of the high-affinity shrimp shell calcium powder in preparation of medicines for treating calcium deficiency symptoms and/or diseases. According to the calcium powder, the high-affinity shrimp shell calcium powder of which the tablet loosening rate after tabletting with a protein base material is not higher than 15%, the tablet loosening rate after tabletting with a carbohydrate base material is not higher than 15% and the tablet loosening rate after tabletting with a saccharide base material is not higher than 10% is applied to calcium deficiency symptoms and/or diseases, for example, the calcium powder has a good curative effect on treating osteoporosis, rickets, chondropathy, nutritional secondary hyperparathyroidism and postpartum convulsion.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a high-affinity shrimp shell calcium powder, a preparation method thereof, and an application in preparation of medicines for treating calcium deficiency symptoms and / or diseases. Background technique [0002] Canine calcium deficiency disease is a relatively common clinical disease. Calcium deficiency can be divided into acute calcium deficiency and chronic deficiency; the main manifestation of acute calcium deficiency is postpartum convulsions. Chronic common calcium deficiency diseases mainly include rickets, canine osteoporosis, nutritional secondary hyperparathyroidism, etc. As Chinese people pay more and more attention to calcium deficiency symptoms, the demand for calcium is also increasing. [0003] Crayfish, namely Procambarus clarkii, is a freshwater lobster species native to the United States, belonging to the family Cryridae, a crustacean, and its annual output accounts for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/612A61K9/14A61K47/36A61K47/38A61P3/02A61P19/10A61P19/08A61P5/20A61P15/00A61P21/02
CPCA61K35/612A61K9/146A61P3/02A61P19/10A61P19/08A61P5/20A61P15/00A61P21/02
Inventor 涂宗财李金林晏侬洋王美丹马天新刘俊王辉李小锋张权
Owner JIANGXI NORMAL UNIV
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