A kind of ultrasonic responsive composite hydrogel and its preparation method and application

A composite hydrogel, responsive technology, applied in the field of medicine, can solve the problems of improper method, less research, increased unintended pregnancy rate, etc., and achieve the effect of high colloidal stability, good biocompatibility, and reversible degradation.

Active Publication Date: 2022-05-27
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Contraception is a relatively important hot issue with little research, especially male contraception. The existing male contraceptive methods such as vasectomy and condoms still cannot achieve satisfactory results
On the one hand, vasectomy is a permanent method of contraception with poor reversibility. Even if it can be recanalized through surgery, the postoperative effect is often unsatisfactory; on the other hand, condoms are the most widely used contraceptive tool for men in sexual life , but the quality of sex life caused by it is poor, which makes many men less willing to use it. Even if it is used, it is easy to be damaged if it is used improperly, resulting in contraceptive failure, which leads to an increase in the rate of unwanted pregnancy; not only that, female contraceptives also have surgical reversal, The problem of poor reversibility

Method used

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  • A kind of ultrasonic responsive composite hydrogel and its preparation method and application
  • A kind of ultrasonic responsive composite hydrogel and its preparation method and application
  • A kind of ultrasonic responsive composite hydrogel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] An ultrasonic responsive composite hydrogel, the preparation method comprising the following steps:

[0052] (1) Weigh sodium alginate (SA) and put it into a serum bottle containing distilled water to prepare a uniform 1.0% (w / V) SA solution;

[0053] (2) The molar ratio of SA monomer to 1-ethyl-(3,3'-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) is 2:2 : 1 dose, add EDC and NHS to the reaction system, stir for more than 10min, thereby activating the carboxyl group on the SA molecule, catalyzing and stabilizing the reaction process of SA and thioketal ethylenediamine (tK);

[0054] (3) Add tK molecules to the solution at a molar ratio of SA monomer to tK molecules of 500:1 and continue stirring for at least 6 hours to prepare an SA-tK solution, which is refrigerated at -20°C for later use;

[0055] The structure of SA-tK is shown in Equation 1:

[0056]

[0057] (4) Add TiO to the SA-tK solution at a ratio of 2.0mg:1000ul at room temperatur...

Embodiment 2

[0061] An ultrasonic responsive composite hydrogel, the preparation method comprising the following steps:

[0062] (1) Weigh sodium alginate (SA) and put it into a serum bottle containing distilled water to prepare a uniform 5.0% (w / V) SA solution;

[0063] (2) The molar ratio of SA monomer to 1-ethyl-(3,3'-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) is 2:2 : 1 dose, add EDC and NHS to the reaction system, stir for more than 10min, thereby activating the carboxyl group on the SA molecule, catalyzing and stabilizing the reaction process of SA and thioketal ethylenediamine (tK);

[0064] (3) Add tK molecules to the solution at a molar ratio of SA monomer to tK molecules of 500:1 and continue stirring for at least 6 hours to prepare an SA-tK solution, which is refrigerated at -20°C for later use;

[0065] (4) Add TiO to the SA-tK solution at a ratio of 1.5mg:1000ul at room temperature 2 Nanoparticles were continuously stirred for more than 10 minutes...

Embodiment 3

[0068] An ultrasonic responsive composite hydrogel, the preparation method comprising the following steps:

[0069] (1) Weigh sodium alginate (SA) and put it into a serum bottle containing distilled water to prepare a uniform 2.0% (w / V) SA solution;

[0070] (2) The molar ratio of SA monomer to 1-ethyl-(3,3'-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) is 2:2 : 1 dose, add EDC and NHS to the reaction system, stir for more than 10min, thereby activating the carboxyl group on the SA molecule, catalyzing and stabilizing the reaction process of SA and thioketal ethylenediamine (tK);

[0071] (3) Add tK molecules to the solution at a molar ratio of SA monomer to tK molecules of 500:1 and continue stirring for at least 6 hours to prepare an SA-tK solution, which is refrigerated at -20°C for later use;

[0072] (4) Add TiO to the SA-tK solution at a ratio of 1.0 mg: 1000 ul at room temperature 2 Nanoparticles were continuously stirred for more than 10 minu...

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Abstract

The invention discloses an ultrasonic-responsive composite hydrogel, a preparation method and application thereof, and belongs to the technical field of medicine. The ultrasound-responsive composite hydrogel is obtained by cross-linking sodium alginate and thioketone ethylenediamine, adding titanium dioxide, and then reacting with calcium chloride; with Ca 2+ The ionic cross-linking together maintains the structure of the hydrogel to achieve the effect of blocking the vas deferens / fallopian tubes; the thioketal bonds between the composite hydrogel molecules have the function of cutting and responding to active oxygen, and the titanium dioxide is triggered by ultrasound to break the thioketal bonds, thereby achieving Non-invasive degradation restores fertility function. The ultrasound-responsive composite hydrogel of the present invention can not only be used for non-invasive and reversible restoration of male / female fertility, but also suitable for reversible contraception of male and female animals.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an ultrasonic responsive composite hydrogel and a preparation method and application thereof. Background technique [0002] Contraception is a relatively important and less researched hot issue, especially male contraception. Existing male contraceptive methods such as vasectomy and condoms still cannot achieve satisfactory results. On the one hand, vasectomy is a permanent contraceptive method with poor reversibility. Even if it can be recanalized by surgery, the postoperative effect is often unsatisfactory; on the other hand, condoms are the most widely used contraceptive tools for men in sexual life. However, the poor quality of sexual life caused by it makes many men have poor willingness to use it. Even if it is used improperly, it is easy to break, resulting in contraceptive failure, resulting in an increase in the rate of unintended pregnancy; not only that, female contra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/02A61L31/14A61K9/06A61K47/36A61K47/02A61K47/20A61K31/734A61P15/16A61P15/18C08J3/075C08J3/24C08L5/04
CPCA61L31/042A61L31/028A61L31/14A61L31/145A61L31/148A61K9/06A61K9/0019A61K47/36A61K47/02A61K47/20A61K31/734A61P15/16A61P15/18C08J3/075C08J3/24A61L2400/06C08J2305/04C08L5/04
Inventor 徐万海王浩王子琦乔增莹刘忠清赵昌浩
Owner HARBIN MEDICAL UNIVERSITY
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