32 results about "Chondropathy" patented technology

Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.

A nutritive flour for preventing the anemia, anorexia, chondropathy, etc of baby, relaxing the senile anemia, arteriosclerosis, cardiovascular and cerebrovascular diseases, diabetes, hyperlipemia, hypertension, etc, and taking care of health is prepared from wheat flour, barley flour, buckwheat flour, soybean protein powder, peanut dreg powder, corn flour and naked oats powder.

The present invention provides an allogenic tissue engineered cartilage graft, it includes: (a) pharmaceutically acceptable bio-degradable material; and (b). cartilage cell, the described cartilage cell is one externally-cultured form primary culture to sixth generation. The invention can be used for effectively curing chondropathy. The invention also provides its preparation and application.

The invention discloses a culture method of adipose-derived stem cells and application of the adipose-derived stem cells in arthritis. The culture method of the adipose-derived stem cells comprises primary culture of the adipose-derived stem cells, subculture of the adipose-derived stem cells, cryopreservation of the adipose-derived stem cells and resuscitation of the adipose-derived stem cells. The adipose-derived stem cells can be made into a medicine for treating arthritis, and the medicine is used for cartilage repair and chondropathy treatment and has a good treatment effect on arthritis.

This invention relates to a compound with EP4 antagonistic activity, or a pharmaceutically acceptable salt with EP4 receptor antagonistic activities, which is useful in the treatment of cartilage disease. This invention also relates to a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof with EP4 receptor antagonistic activities, which is useful in the treatment of cartilage disease. This invention also relates to a pharmaceutical composition for the treatment of cartilage disease which comprises a therapeutically effective amount of a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof. Further this invention relates to a method for the treatment of cartilage disease in an animal subject including a mammalian subject, which comprises administering to the animal subject including a mammalian subject a compound of the formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof.

The invention discloses a medicine which cures osteoarthritis and is a compound which is formed by combining (S)-ibuprofen and dextrosamine or the medicine salt thereof according to 1:3 of mass ratio. The (S)-ibuprofen and the dextrosamine are prepared into compound preparation. The characteristics of rapid drug effects and strong abirritation of the (S)-ibuprofen can be used for rapidly relieving symptoms on the one hand; on the other hand, the dextrosamine can defer cartilage degeneration process, repairs cartilage pathological changes, and prevents, even reverses the disease process. Meanwhile, the (S)-ibuprofen and the dextrosamine are prepared into the compound preparation, which can reduce the dose of single medicine and further reduce the toxic side effects. The compound preparation prepared by the (S)-ibuprofen and the dextrosamine of the invention becomes a new medicine which can cure the osteoarthritis.

The inventors of the present invention searched for a substance that is effective in treating a cartilage disorder, and as a result, found that, in an animal model of joint cartilage deficiency, an HMGB1 fragment peptide having a specific amino acid sequence exhibits the effect of reproducing a healthy cartilage tissue including a hyaline cartilage. Based on this finding, the present invention provides a pharmaceutical composition that contains the specific HMGB1 fragment peptide and that is for preventing and / or treating a cartilage disorder.

The use of salt-inducible kinase 3 allows screening for a substance having an effect of increasing cartilage volume and / or an effect of normalizing chondrocyte differentiation. A modified chondrocyte in which the expression or function of salt-inducible kinase 3 gene is inhibited or enhanced can be used to ameliorate a disease associated with reduced cartilage volume and / or a disease associated with impaired cartilage growth.

The present invention relates to an ultrasound image quantitative evaluation system, comprising: an image preprocessing module for preprocessing acquired joint ultrasound images; an image segmentation module for image segmentation of joint ultrasound images; a quantitative analysis index extraction module, It is used for quantitative analysis index extraction of joint ultrasound images; the parameter joint analysis module is used for multi-parameter joint analysis of joint ultrasound images. The present invention automatically segments the front and rear walls and internal regions of cartilage on the ultrasonic image, and conducts quantitative analysis on the segmented regions of interest, extracts information related to ultrasonic echo intensity, sound attenuation, cartilage thickness, and scattering sub-statistical distribution. Quantitative analysis indicators, and then use the method of multivariate analysis to comprehensively analyze various indicators, so as to realize the non-invasive and quantitative evaluation of the degree of articular cartilage lesions.

This invention provides a method for administration of an effective amount of RANKL-binding molecules that act on prechondrocytes and / or mesenchymal stem cells, accelerate cartilage differentiation, proliferation, and maturation of such cells, enhance chondrocyte differentiation, and induce chondrocyte proliferation to induce chondrocyte proliferation and differentiation or increase cartilage matrix production and a pharmaceutical composition used for inducing chondrocyte proliferation and differentiation or increasing cartilage matrix production. The pharmaceutical composition used for treatment or prevention of a chondropathies comprises, as an active ingredient, a compound that acts on prechondrocytes and / or mesenchymal stem cells and induces at least one of the following: (a) acceleration of prechondrocyte and / or mesenchymal stem cell differentiation; (b) acceleration of prechondrocyte and / or mesenchymal stem cell proliferation; (c) acceleration of prechondrocyte and / or mesenchymal stem cell maturation; (d) enhancement of chondrocyte differentiation; (e) chondrocyte proliferation; and (f) increased production of the cartilage matrix.

The invention relates to a preparation method of soluble calcium citrate. The preparation method of the soluble calcium citrate is characterized by comprising the following steps: (1) weighing raw materials, namely citric acid monohydrate, calcium hydroxide and water to feed to a reaction kettle, wherein the mass ratio of the citric acid monohydrate to the calcium hydroxide is 2:3; (2) starting up to carry out chemical reaction for half an hour; (3) shutting down for half an hour, and adding ethanol, so that the chemical reaction becomes mature; (4) starting up for half an hour, and discharging the soluble calcium citrate. The calcium citrate prepared by the method contains soluble calcium, so that the calcium citrate can be more easily absorbed by people and animals, and is a food additive for supplementing calcium and strengthening the bone, and a drug for treating osteoporosis, cramp in the leg and chondropathy. The soluble calcium citrate also can be used for preparing a soluble calcium citrate injection and a soluble calcium citrate oral liquid. The application range of the soluble calcium citrate greatly exceeds that of insoluble calcium citrate.

The invention is relevant to chemistry of organic compounds, pharmacology and medicine, and is related to prevention and treatment of musculoskeletal diseases in human and animals associated with the disorder of bone and / or cartilage metabolism, particularly with such musculoskeletal diseases as osteoporosis, osteoarthritis and osteochondrosis, using a new salt form of 2,2-dimethyl-6-((4-((3,4,5-trimethoxyphenyl)amino)-1,3,5-triazine-2-yl)amino)-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one. A salt of this compound with 4-methylbenzenesulfonic acidincluding its hydrates, solvates and polymorphic modifications of the salt, hydrates and solvates is featured with acceptable pharmacokinetic parameters and increased efficiency in the inhibition of Src-family kinases and Syk kinase, as well as other therapeutically significant kinases. This invention also covers pharmaceutical compositions containing therapeutically effective amount of the salt according to the invention.

The invention discloses a preparation for preventing chondropathy of pigs and a preparation method of the preparation. The preparation comprises, by weight, 10-18 parts of fructus psoraleae, 6-12 parts of collagen, 1-3 parts of zinc methionine, 1-3 parts of cupric glycinate, 1-3 parts of ferrous fumarate, 15-30 parts of egg shells, 30-40 parts of soybean meal, 0.2-0.5 part of radix astragali, 0.1-0.4 part of folium isatidis and 1-3 parts of vitamin C. The preparation method has the advantages that active ingredients of Chinese herbal medicine, active peptides, vitamins and other substances areeffectively combined through enzymatic hydrolysis, and these components encircle calcium ions to form a soluble compound when reaching the lower ends of small intestines such as the ileum and a partof the jejunum. It can be seen that the preparation can obviously improve the absorption of calcium by the human body, improve the bioavailability of calcium, promote growth, bone formation and mineralization and increase bone weight and ash content, and thus chondropathy of the pigs is effectively prevented.