3 results about "Chondropathy" patented technology

The invention discloses an articular cartilage MRI (Magnetic Resonance Imaging) image intelligent enhancement and contrast optimization system, which belongs to the technical field of medical image processing and comprises a cartilage feature extraction module, a self-adaptive enhancement module, a contrast optimization module and a quality evaluation feedback module, the cartilage feature extraction module realizes cartilage region classification and structural analysis based on T2 relaxation time distribution features and multi-scale structure tensor features; the adaptive enhancement module performs differential enhancement according to the region type and the structural feature; the contrast optimization module realizes contrast dynamic optimization through nonlinear mapping and edge gradient adaptive adjustment; according to the articular cartilage MRI image display system and method, the display quality of the articular cartilage MRI image is remarkably improved, the cartilage display definition is improved by 73% or above compared with that of an original image, and a high-quality imaging basis is provided for accurate diagnosis of chondropathy.

Methods of using cell communication network factor 3 (CCN3) for the treatment of bone or cartilage disorders are provided. Also provided are methods of gene therapy, including methods of expressing CCN3 in vivo in an amount effective to promote new bone or cartilage growth. In addition, methods of screening for agonists, mimetics, and analogs of CCN3 are provided.

The present invention relates to a pharmaceutical composition in the form of a sterile and injectable dosage form comprising a controlled release dosage form comprising colchicine for use in the treatment of arthropathy, such as osteoarthritis, aggressive hand osteoarthritis and any other type of chondropathy, by intraarticular injection of said pharmaceutical composition into the joint, such as osteoarthritis, aggressive hand osteoarthritis, and any other type of chondropathy. The present invention relates to colchicine, in particular colchicine, and / or for the treatment of pain-related arthropathy, and / or for the protection of joints, bones and / or cartilages, in which 80% by weight of colchicine is released for more than one month, and in which colchicine is present in a concentration of 1 to 27.5 mg per mL of sterile and injectable dosage, and / or for the treatment of pain-related arthropathy, and / or for the protection of joints, bones and / or cartilages. The invention also relates to a sterile and injectable pharmaceutical composition comprising a controlled release dosage form containing colchicine, which has a suitable in vitro dissolution characteristic. The invention also relates to a formulation in powder form and to a pharmaceutical composition in sterile and injectable dosage form form suitable for intra-articular injection comprising colchicine, in particulate form comprising a polymer matrix, and to a related kit or article of manufacture.