7 results about "Chondropathy" patented technology

The invention relates to the technical field of joint repair materials, and discloses a preparation method of juvenile cartilage fragment combined light-cured lubricating coating hydrogel, which comprises the following steps: preparing MeHA, preparing DMA-MPC and preparing MeHA-P-DM; the invention further discloses the MeHA-P-DM hydrogel carrier and application. The hydrogel carrier MeHA-P-DM prepared by the invention can effectively deliver PJAC, has good biocompatibility, and has the advantages of improving cell survival rate and biological activity, promoting cartilage repair and regeneration, relieving inflammation and exerting good lubricating property and anti-pollution capacity; meHA (at) P (at) DM has a good transformation advantage in the aspect of PJAC implantation, and a more efficient treatment means is provided for patients suffering from joint chondropathy.

The present invention discloses the application of celery seeds in promoting bone development, which is specifically manifested in that the calcium and phosphorus elements contained in celery seeds can promote bone development, have a synergistic effect in promoting adolescent bone development, enhance the absorption of trace elements that are beneficial to bone development, and can also prevent the occurrence of rickets during adolescence to a certain extent. Its mechanism of action is that celery seeds are rich in calcium and phosphorus, which are both necessary elements for bone development. At the same time, the calcium and phosphorus elements rich in celery seeds can prevent osteoporosis caused by bone calcium and phosphorus deficiency for the elderly. In addition, celery seeds can also enhance bone density, improve its toughness, and further improve the overall comprehensive level of bones. Celery seeds are also a dual-purpose crop for medicine and food, are easy to obtain, and have no toxic side effects, which is conducive to widespread use.

The invention discloses an articular cartilage MRI (Magnetic Resonance Imaging) image intelligent enhancement and contrast optimization system, which belongs to the technical field of medical image processing and comprises a cartilage feature extraction module, a self-adaptive enhancement module, a contrast optimization module and a quality evaluation feedback module, the cartilage feature extraction module realizes cartilage region classification and structural analysis based on T2 relaxation time distribution features and multi-scale structure tensor features; the adaptive enhancement module performs differential enhancement according to the region type and the structural feature; the contrast optimization module realizes contrast dynamic optimization through nonlinear mapping and edge gradient adaptive adjustment; according to the articular cartilage MRI image display system and method, the display quality of the articular cartilage MRI image is remarkably improved, the cartilage display definition is improved by 73% or above compared with that of an original image, and a high-quality imaging basis is provided for accurate diagnosis of chondropathy.

Methods of using cell communication network factor 3 (CCN3) for the treatment of bone or cartilage disorders are provided. Also provided are methods of gene therapy, including methods of expressing CCN3 in vivo in an amount effective to promote new bone or cartilage growth. In addition, methods of screening for agonists, mimetics, and analogs of CCN3 are provided.

The present invention relates to a pharmaceutical composition in the form of a sterile and injectable dosage form comprising a controlled release dosage form comprising colchicine for use in the treatment of arthropathy, such as osteoarthritis, aggressive hand osteoarthritis and any other type of chondropathy, by intraarticular injection of said pharmaceutical composition into the joint, such as osteoarthritis, aggressive hand osteoarthritis, and any other type of chondropathy. The present invention relates to colchicine, in particular colchicine, and / or for the treatment of pain-related arthropathy, and / or for the protection of joints, bones and / or cartilages, in which 80% by weight of colchicine is released for more than one month, and in which colchicine is present in a concentration of 1 to 27.5 mg per mL of sterile and injectable dosage, and / or for the treatment of pain-related arthropathy, and / or for the protection of joints, bones and / or cartilages. The invention also relates to a sterile and injectable pharmaceutical composition comprising a controlled release dosage form containing colchicine, which has a suitable in vitro dissolution characteristic. The invention also relates to a formulation in powder form and to a pharmaceutical composition in sterile and injectable dosage form form suitable for intra-articular injection comprising colchicine, in particulate form comprising a polymer matrix, and to a related kit or article of manufacture.

The application discloses a traditional Chinese medicine composition for preventing and treating knee osteoarthritis and application thereof, and relates to the technical field of knee osteoarthritis treatment. The traditional Chinese medicine composition is Sanqiang Decoction which is composed of the following raw materials in parts by weight: Eucommia ulmoides leaves 90-150 parts, Chaenomeles speciosa 60-120 parts, Astragalus membranaceus 90-150 parts, Gastrodia elata 35-65 parts, Dendrobium 35-65 parts, Pueraria lobata 90-150 parts, Curcuma longa 35-65 parts, Persicae Semen 35-65 parts, Coix seed 60-120 parts, Fructus Corni 75-125 parts and calcium gluconate 9-15 parts. The Sanqiang Decoction in the application can improve the pathological state of cartilage and the microstructure parameters of subchondral bone of knee osteoarthritis, improve the antioxidant stress capacity, and improve the quadriceps atrophy caused by knee osteoarthritis, and has good pharmacological effects. The mechanism is related to the activation of TGF-beta 1 / Smad3, Nrf2-Keap1 and PI3K / AKT / FOXO1 pathways.

The invention relates to the technical field of medicine and food, in particular to an extract with an osteoarthritis prevention and treatment effect and application thereof, the extract is a mulberry polyphenol extract obtained by taking mulberry as a raw material and extracting with water and an alcohol solvent or combining with a refining process and a monomer of the mulberry polyphenol extract. The mulberry polyphenol extract is screened and evaluated by using an in-vitro model of cartilage cell injury induced by hydrogen peroxide (H2O2) and an osteoarthritis animal model induced by D-galactose subcutaneous injection, and the mulberry polyphenol extract is found to be capable of effectively improving cartilage cell injury, reducing proteoglycan secretion, obviously inhibiting joint osteomalacia change and improving osteoarthritis activity. The level of articular cartilage inflammatory factors is reduced, and the effect and the total polyphenol content are in a definite dose-effect relationship. The mulberry total polyphenol is an effective part for intervening the osteoarthritis, so that the mulberry total polyphenol has a wide application prospect in the aspect of preparing products for preventing and treating the osteoarthritis.