89 results about "Testicle" patented technology

Embodiments of the present invention provide a pharmaceutical intervention in the neonatal pig that inhibits and delays development and activation of the HPG axis, growth of the boar testis and inhibits testicular production of testosterone and androstenone, which prevents the development of aggressive behavior in the maturing boars and the presence of boar taint in the meat. The invention comprises treatment with a combination of an androgen and an estrogen in the newborn male piglet using extended drug delivery methods, with a defined duration of no more than 12 weeks, for the purpose of inhibiting the production of testosterone and androstenone and the accumulation of the boar taint-inducing molecules androstenone and skatole in the fat.

The invention relates to the technical field of biology, in particular to a swelling hippocampal peptide as well as a preparation method and application thereof. Comprising a polypeptide with an amino acid sequence as shown in SEQ ID NO.1. The hippocampus antioxidative peptide is prepared by adopting an ultrahigh pressure pretreatment and enzymolysis technology, the adopted extraction process is simple in route, and the time and the production cost are effectively saved; an animal model is utilized to prove the antioxidation effect and the effect of improving male reproductive disorder and testis injury of the hippocampal swelling peptide; and on the basis, a novel peptide fragment with high activity, no toxicity and no sensitization is obtained.

The invention relates to the technical field of biology, in particular to a swelling hippocampus antioxidative peptide as well as a preparation method and application thereof. Comprising a polypeptide with an amino acid sequence as shown in SEQ ID NO.1. The hippocampus antioxidative peptide is prepared by adopting an ultrahigh pressure pretreatment and enzymolysis technology, the adopted extraction process is simple in route, and the time and the production cost are effectively saved; an animal model is used for proving the antioxidation effect of the hippocampus erectus antioxidative peptide and the effect of improving male reproductive disorder and testis injury; and on the basis, a novel peptide fragment with high activity, no toxicity and no sensitization is obtained.

The invention discloses a method for generating haploid sperm-like cells through in-vitro differentiation of pluripotent stem cells and application of the haploid sperm-like cells. Human pluripotent stem cells are firstly differentiated into ectoderm-like cells, then the ectoderm-like cells are spontaneously gathered and converted into primordial germ cell-like cells under the induction of ectoderm induction factors, and then the primordial germ cell-like cells and testicular sertoli cells are subjected to mixed culture to form recombinant testicular tissues; the recombinant testis tissue enters meiosis under the induction of nutrition limitation and retinoic acid, then meiosis is completed under the stimulation of meiosis second-stage induction factors such as testosterone, follicle-stimulating hormone and pituitary extract, and interaction between primordial germ cell-like cells and testis supporting cells is enhanced by using small molecules SB431542, so that the meiosis of the testis is enhanced. And finally inducing to generate haploid sperm-like cells. According to the invention, a new tool can be provided for researching a molecular mechanism of male reproduction, and an important thought can be provided for research and transformation of asthenospermia, oligospermia, drug screening and the like.

This invention discloses a traditional Chinese medicine composition for treating male infertility due to liver stagnation and kidney deficiency, its preparation method, and its application, belonging to the fields of traditional Chinese medicine pharmaceutical technology and andrological reproductive health technology. The composition is formulated with Bupleurum chinense, Tribulus terrestris, Cynomorium songaricum, Cuscuta chinensis, Cornus officinalis, and Epimedium brevicornu in specific weight proportions, following the principles of soothing the liver and relieving stagnation, tonifying the kidney and replenishing essence, and unblocking the meridians to treat impotence. This invention employs an alcohol-water dual-phase fractional extraction process, and can be prepared into various dosage forms such as granules, capsules, and tablets. Pharmacological experiments have confirmed that the composition of this invention can increase sperm density and progressively motile sperm rate, improve penile tissue nitric oxide synthase (NOS) activity, regulate reproductive hormones, and reduce testicular oxidative damage; serum pharmacochemistry and metabolomics have clarified the active components entering the bloodstream and their pathways of action. This invention features a refined formulation, abundant medicinal resources, and simple preparation, making it suitable for large-scale production and clinical application in treating male infertility due to liver stagnation and kidney deficiency.

A method of treating male hypogonadism in a subject in need thereof includes administering to the subject testicular organoids generated from isolated male progenitor cells. The method can be used to slow or halt the progression of age-related diseases, and increase healthspan and longevity, in hypogonadal males. The method can be used with subjects that have not or are not receiving testosterone replacement therapy. The method does not require that the subject is pre-treated with CG. The testicular organoid includes cells expressing GFRA1, VEGF, VEGFR2, PDGF-Rα, Cyp11A1, 3β-HSD, 17β-HSD, LHCGR, α-SMA, CD11b, MHC CII, CD64, CD95, Sox9, AR, inhibin β-B, and FSHR.

This invention provides a sauna testicular cover that can be stably placed on the seat of a sauna room and protect the user's testicles from excessive heat. [Solution] The sauna testicle cover comprises a bottom portion having a flat outer bottom surface, a wall portion that rises outward in a convex shape from around the bottom portion, and an opening formed at the upper end of the wall portion. This sauna testicle cover is configured to accommodate the user's testicles, which are received through the opening, inside the bottom portion and wall portion when the outer bottom surface is in contact with the seat surface of the sauna room. With this sauna testicle cover, the user's testicles can be protected from excessive heat while stably placed on the seat surface of the sauna room.

The invention provides an application of ergothioneine as a testis oxidative stress regulator. The invention provides a multi-target intervention method based on ergothioneine, which systematically improves sperm quality reduction caused by obesity by cooperatively regulating key links such as oxidative stress level, hormone secretion state and mitochondrial function. According to the invention, a safe and effective intervention effect with a clear action mechanism can be realized, and a new technical approach is provided for the treatment of obesity-related male reproductive dysfunction. The invention also provides application of the ergothioneine as the testicular steroid generation accelerant.

A lower body garment is disclosed having a sling assembly for securing male genitalia. The sling assembly is configured with limited, prescribed attachment points, which enables increased comfort and support, for the wearer. Moreover, the sling assembly provides a comfortable encapsulation that reduces the jostling of the testicles during athletic endeavors. The sling assembly configuration can further provide moisture management to reduce itching, chafing, and infection.

Disclosed herein are methods of reducing pathological inflammation and effects thereof through administration of tissues associated with regenerative and / or tolerogenic activity. In some embodiments, such tissues can include placental, ocular, testicular, and osseous tissues. Augmentation of therapeutic effects of said tissues may be achieved through contact with Injury Mimetics.

The invention belongs to the technical field of medicines, and particularly discloses application of afzelin in preparation of an anti-testis aging medicament, and testis aging resistance is particularly improvement or recovery of an aged testis tissue structure. The invention also provides a medicament for resisting testis aging. The medicament contains afzelin. The invention provides a new application of afzelin, the afzelin can be used for saving senescence testicular tissue structure disorder, remarkably reducing the epididymal sperm deformation rate and increasing the number of supporting cells and undifferentiated spermatogonium cells, the new application value of afzelin is developed, and a theoretical basis is provided for developing afzelin into anti-reproductive aging drugs.

The application of unilateral or bilateral permanent prostheses to the labium majus in the external genitalia of women for reconstructive and aesthetic purposes may make it appear fuller. The labium majus may lose its fullness and symmetry due to menopause, rapid weight gain and loss, traumas, cancers, and infectious diseases. Aesthetic interventions (e.g., hyaluronic acid filler injection and fat grafting) aiming to provide the labium majus with fullness have become very popular in recent years. The hyaluronic acid filler is used for reconstructive purposes to achieve fullness in labium majus. However, the maximum amount that can be injected is 3 mL, which is often insufficient for the desired outcome and its effect lasts for a maximum of 1 year. Autologous fat grafting is administered by taking 18–120 mL of fat from patients themselves; however, its effect usually lasts 1 to 4 years. The application of a prosthesis will provide labium majus with fullness and this effect will be long-lasting. The outer edge of the prosthesis is convex and the inner edge is concave. In male genitalia, prostheses have been used since 1950 to provide the testicles with fullness. Scientific studies have shown that these prostheses positively affect self-confidence and body perception indices in men.

The application belongs to the field of regenerative medicine and nano drug delivery system, and particularly relates to a drug-loaded exosome for improving the testosterone secretion capacity of testicular interstitial cells and a preparation method and application thereof. The application links a targeting FATE1 polypeptide to the surface of MSC-derived exosomes by a chemical coupling method, and loads a small molecule compound in the exosomes by electroporation, so as to obtain modified MSC-derived exosomes. The obtained exosomes can obtain the targeting capacity in testicular interstitial cells, and the natural repair capacity of MSC-derived exosomes and the release of small molecule drugs promote the repair of damaged cells, improve the testosterone secretion capacity of testicular interstitial cells, and relieve male erectile dysfunction caused by diseases or aging.

We offer bifurcated pants that reduce sweating, stuffiness, odor, and itching. [Solution] A pair of bifurcated men's pants (trunks, briefs, boxer briefs, shorts, sportswear, swimming pants, swimwear, track and field pants, jerseys, volleyball pants, basketball pants, badminton pants, table tennis pants, gear shorts, bodysuit), consisting of a pant body, a third crotch pouch (for the testicles and penis) provided on the front of the pant body, and a tubular object, with the attachment angle set to 5 to 100 degrees from the pant body.

This utility model relates to a tissue separation device for spermatic vein ligation surgery, belonging to the field of male infertility surgery and medical devices. The separation device includes an intermediate pad with a central groove for accommodating a movable soft coil; hooks are provided on the opposite end face of the intermediate pad opposite the groove. The hooks bend downwards on both sides, effectively fixing the external spermatic fascia and cremaster muscle, fully exposing the surgical area. The silicone soft coil can be inserted between the blood vessels (testicular artery, pampiniform plexus) and the cremaster muscle, fully exposing the vessels to be ligated. The tissue separation device for spermatic vein ligation surgery provided by this utility model uses a medical-grade silicone soft coil, which has good biocompatibility, allows for flexible intraoperative operation, and its softness avoids damage to blood vessels.

Prodrugs of testosterone and their use in alleviating, improving or reducing a risk of developing one or more conditions associated with androgen deprivation therapy (ADT), including orchiectomy or administration of a luteinizing hormone-releasing hormone agonist / antagonist, for the treatment of prostate cancer, including metastatic prostate cancer. In some aspects the prodrugs can be administered intranasally to target the central nervous system.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

The invention provides a product related to non-obstructive azoospermia microscopic sperm extraction, application and a method. The invention discloses application of a reagent for detecting clinical information in preparation of a non-obstructive azoospermia microscopic sperm extraction product. The clinical information comprises age, testis size, testosterone, estradiol E2, androgen T, follicle stimulating hormone FSH, statin B and seminal plasma cell-free DNA motif diversity score. The prediction method comprises the following steps: acquiring clinical information of a to-be-tested object; inputting the clinical information into a prediction model based on machine learning to obtain a probability P of successful microscopic sperm extraction; and according to comparison between the probability P and a reference value, diagnosing or predicting whether the to-be-detected object is suitable for microscopic sperm collection. The prediction method provided by the invention can be used for improving the accuracy of predicting the success rate of microscopic sperm extraction of non-obstructive azoospermia, and has a relatively good clinical application value.

The application provides a preparation method of a stem cell exosome composition and application of the stem cell exosome composition in male sexual dysfunction, and the preparation method comprises the following steps: extracting stem cell exosomes; combining the stem cell exosomes with a stabilizing peptide; and preparing a stem cell exosome hydrogel; the stabilizing peptide comprises an amino acid sequence as shown in SEQ ID NO: 1. The stem cell exosome composition obtained by the method can improve the stability of the exosomes, improve the in-vivo bioavailability, prevent and relieve testicular injury, and inhibit inflammatory reactions.

The application relates to application of astragaloside B to preparation of a medicine for treating oligoasthenospermia and the medicine, and belongs to the field of traditional Chinese medicine. Through animal experiments, it is shown that the astragaloside B significantly improves the quantity and quality of rat sperms, and no obvious side effects are observed during the treatment. The astragaloside B has the effects of inhibiting oxidation stress, promoting secretion of testosterone, regulating secretion of follicle stimulating hormone and luteinizing hormone, promoting growth and maturation of sperms, effectively improving sperm function, and enhancing the repair capacity of the body to testicular injury. Moreover, no obvious side effects are observed during the treatment of the astragaloside B on oligoasthenospermia.

The invention belongs to the field of basic medical research, and particularly relates to a testicular toxicity animal model establishing method which comprises the following steps: performing intragastric administration on male rats with a preparation containing podophyllotoxin according to the dosage of 15 mg / kg per day; the medicine is continuously administrated for 4 days; according to the method, the rat can be induced to generate testicular toxicity phenotypes, and the phenotypes at least include that the number of sperms is remarkably reduced, the activity of the sperms is reduced, the testosterone level of serum is abnormally increased, and spermatogenic tubules in testicular tissue are irregular in shape and spermatogenic epithelium is thinned.

The invention discloses a traditional Chinese medicine formula with a reproductive system radiation damage protection effect as well as a preparation method and application of the traditional Chinese medicine formula. The traditional Chinese medicine formula comprises the following components in parts by mass: 15-30 parts of Chinese yam, 6-15 parts of dogwood, 10-30 parts of astragalus membranaceus, 10-30 parts of prepared rehmannia root, 10-15 parts of spina date seed, 6-15 parts of fructus psoraleae, 5-15 parts of fructus lycii and 3-9 parts of rhodiola rosea. In the traditional Chinese medicine formula provided by the invention, all the components have a synergistic effect, so that the injury of ionizing radiation to a reproductive system can be effectively relieved, the pathological change of testis tissues is remarkably improved, sperm quality parameters are improved, the apoptosis process of testis cells is inhibited, the injury caused by oxidative stress is repaired, and the DNA injury degree is reduced; therefore, the technical defects of high toxicity, high cost, insufficient protective effect on the reproductive system and the like of the existing radiation protective agent are overcome.

The invention relates to the technical field of environmental medicine and reproductive toxicology, in particular to application of aspirin in prevention and / or treatment of male reproductive injury caused by rare earth elements. The invention also relates to a method for improving sperm quality reduction caused by rare earth element exposure. The method comprises the step of administering an effective dose of aspirin or a pharmaceutically acceptable salt thereof to an individual in need thereof. The invention also relates to a pharmaceutical composition for preventing and / or treating male reproductive injury caused by rare earth elements. The cognitive limitation of a traditional oxidative stress mechanism is broken through, a new mechanism of rare earth reproductive toxicity is disclosed from a new perspective of testis immune microenvironment for the first time, and an intervention scheme aiming at the new mechanism is provided. According to the invention, the aspirin is creatively used for solving the novel public health problem of low-dose long-term exposure of rare earth elements for the first time, and a new application field is developed for non-steroidal anti-inflammatory drugs.

The invention discloses an AI auxiliary remote consultation system for testicular nucleoprotein carcinoma, and relates to the technical field of medical information, and the system comprises a multi-modal data fusion processing module which is used for receiving and preprocessing patient multi-modal medical data from different medical institutions; the dynamic feature extraction and tumor evolution modeling module is used for extracting dynamic pathological features related to the testicular nucleoprotein cancer from the fused multi-dimensional feature tensor; the core of the expert diagnosis logic deep simulation module is a deep reinforcement learning network which is pre-trained and continuously learns online; and the real-time interaction and decision synchronization module is used for coordinating data streams and control signals among the modules in the system and managing real-time communication with a remote terminal user. The system solves the problems that an existing system is insufficient in testicular nucleoprotein cancer multi-modal data fusion capability, poor in rare case generalization and low in real-time decision-making efficiency, and the diagnosis accuracy and the remote cooperation efficiency are improved.

A device for enhancing the tumescence of an erection is disclosed. The device has a body shaped to conform to the dorsal surface of a wearer's penis. A latch is disposed on one end of the body and a loop of elastic material extends from the opposite end of the body. A wearer attaches the device by stretching the loop from the body, placing the body against his penis, inserting his testicles through the loop and engaging the loop with the latch. One portion of the loop encircles the shaft of the penis in front of the scrotum and a second encircles the penis and scrotum behind the scrotum. Elastic rebound of the loop applies compressive force to the penis and scrotum, modifying blood flow in the penis and increasing tumescence.