164 results about "Testicle" patented technology

The invention belongs to the technical field of biological medicines, and particularly relates to a composition for treating male erectile dysfunction and application thereof. The oyster polypeptide is prepared by enzymolysis of oyster protein, can effectively promote proliferation of testicular interstitial cells, enhance and improve sexual desire and improve sexual behavior, has certain clinical application value, has the advantages of simple preparation, easy absorption and the like, and is easy to popularize and apply.

Embodiments of the present invention provide a pharmaceutical intervention in the neonatal pig that inhibits and delays development and activation of the HPG axis, growth of the boar testis and inhibits testicular production of testosterone and androstenone, which prevents the development of aggressive behavior in the maturing boars and the presence of boar taint in the meat. The invention comprises treatment with a combination of an androgen and an estrogen in the newborn male piglet using extended drug delivery methods, with a defined duration of no more than 12 weeks, for the purpose of inhibiting the production of testosterone and androstenone and the accumulation of the boar taint-inducing molecules androstenone and skatole in the fat.

The invention relates to the technical field of biology, in particular to a swelling hippocampal peptide as well as a preparation method and application thereof. Comprising a polypeptide with an amino acid sequence as shown in SEQ ID NO.1. The hippocampus antioxidative peptide is prepared by adopting an ultrahigh pressure pretreatment and enzymolysis technology, the adopted extraction process is simple in route, and the time and the production cost are effectively saved; an animal model is utilized to prove the antioxidation effect and the effect of improving male reproductive disorder and testis injury of the hippocampal swelling peptide; and on the basis, a novel peptide fragment with high activity, no toxicity and no sensitization is obtained.

A fertility-enhancing cooling seat for lowering temperatures of human testicles so as to increase sperm quality and quantity. The cooling seat includes: a top flexible portion and a base portion; a bottom flexible portion coupled to the top flexible portion, the bottom flexible portion forming a seal with the base portion, portions of the bottom flexible portion and portions of the top flexible portion defining isolated cooling cells with cooling-cell volumetric spaces; a phase-change material located in the cooling-cell volumetric spaces, the phase-change material configured to change from a solid phase to a liquid phase at a first temperature and that is configured to change from a liquid phase to a solid phase at a second temperature that is lower than the first temperature. At least one of the isolated cooling cells defines a diameter that is larger than a diameter of the other of the cooling cells.

The invention relates to the technical field of biology, in particular to a swelling hippocampus antioxidative peptide as well as a preparation method and application thereof. Comprising a polypeptide with an amino acid sequence as shown in SEQ ID NO.1. The hippocampus antioxidative peptide is prepared by adopting an ultrahigh pressure pretreatment and enzymolysis technology, the adopted extraction process is simple in route, and the time and the production cost are effectively saved; an animal model is used for proving the antioxidation effect of the hippocampus erectus antioxidative peptide and the effect of improving male reproductive disorder and testis injury; and on the basis, a novel peptide fragment with high activity, no toxicity and no sensitization is obtained.

The invention relates to the technical field of reproductive medicine, in particular to a high-quality sperm acquisition method based on a testis tissue sample of an azoospermia patient, which comprises the following steps: inputting a first frame of a testis tissue sample microscopic video sequence into a target detection model, outputting a sperm detection frame and confidence, and taking the position of the detection frame as a starting point of a motion trail; a dynamic confidence matching strategy is adopted, firstly, a prediction trajectory is matched with a high-confidence detection result, then, a real leak detection target is complemented with a low-confidence target, multi-stage Hungary matching is achieved through confidence guidance, and all sperm movement trajectories obtained in each frame are obtained; and based on multiple frames of images corresponding to all sperm movement tracks corresponding to the microscopic video sequence, selecting the multiple frames of images according to a preset number of confidence coefficients to construct a candidate morphological analysis sample set, and performing kinematics parameter calculation and morphological analysis to obtain high-quality target sperms. According to the method, the recognition efficiency of high-quality sperms is improved, the sperms with higher quality can be obtained, and the subsequent fertilization success rate is further improved.

A lower body garment is disclosed having a sling assembly for securing male genitalia. The sling assembly is configured with limited, prescribed attachment points, which enables increased comfort and support, for the wearer. Moreover, the sling assembly provides a comfortable encapsulation that reduces the jostling of the testicles during athletic endeavors. The sling assembly configuration can further provide moisture management to reduce itching, chafing, and infection.

The invention discloses application of mangiferin in preparation of a protective agent for testicular sertoli cells and preparation of a medicine for treating male infertility diseases, and relates to the technical field of medicine application. Wherein the mangiferin can play a role in protecting the sertoli cells, and the protection role is reflected in ways of improving the cell viability of the sertoli cells, inhibiting the apoptosis of the sertoli cells, inhibiting the oxidative stress of the sertoli cells, inhibiting the inflammatory response of the sertoli cells and the like; meanwhile, mangiferin can be used for treating male infertility diseases in ways of relieving weight loss, repairing testis, improving endocrine system functions, inhibiting oxidative stress of testis tissues, inhibiting inflammatory response of the testis tissues and the like. Wherein the mangiferin can inhibit the inflammatory reaction mainly by inhibiting the activation of NLRP3 inflammasome to inhibit the NLRP3 pathway, so that the inflammation and even pyroptosis of testicular sertoli cells are remarkably reduced to improve spermatogenesis, and the male infertility disease is well treated.

The invention provides a functional peptide with a yang tonifying effect, a seal penis peptide and a preparation method and application of the functional peptide and the seal penis peptide. The functional peptide comprises a peptide fragment pER and can promote testicular interstitial cells to secrete testosterone. Testosterone is steroid hormone and can be secreted by testicular interstitial cells through enzymatic reaction. The low testosterone level in serum can cause male testicular atrophy and low sperm survival rate, so that the male reproductive function is influenced, and the phenomena of poor sexual desire, premature ejaculation, erectile dysfunction and the like can also be caused. In addition, the testosterone also has the effects of maintaining muscle strength and quality, maintaining bone density and strength, refreshing, improving physical ability and the like. Therefore, the functional peptide provided by the invention has the effect of promoting the secretion of testosterone, which means that the functional peptide not only can effectively improve the male sexual function, but also can alleviate the damage of male sexual dysfunction to the body and spirit.

The utility model discloses a paracentesis auxiliary device which is installed on supports on two sides of a sickbed body and comprises a first connecting rod and a second connecting rod which are respectively connected with the supports on the two sides of the sickbed body, and an adjusting cross beam is connected between the first connecting rod and the second connecting rod in a sliding mode. The outer wall of the adjusting cross beam is sleeved with a connecting sleeve, the two ends of the outer wall of the connecting sleeve are each sleeved with an elastic connecting belt, and the end, away from the connecting sleeve, of each elastic connecting belt is detachably connected with a binding net bag. The fixing device can be conveniently adjusted according to the positions of the testis and the penis of a patient, the application range is widened, the stability of the whole structure in the puncture operation process is enhanced, and therefore the better fixing effect is achieved.

The invention discloses a method for generating haploid sperm-like cells through in-vitro differentiation of pluripotent stem cells and application of the haploid sperm-like cells. Human pluripotent stem cells are firstly differentiated into ectoderm-like cells, then the ectoderm-like cells are spontaneously gathered and converted into primordial germ cell-like cells under the induction of ectoderm induction factors, and then the primordial germ cell-like cells and testicular sertoli cells are subjected to mixed culture to form recombinant testicular tissues; the recombinant testis tissue enters meiosis under the induction of nutrition limitation and retinoic acid, then meiosis is completed under the stimulation of meiosis second-stage induction factors such as testosterone, follicle-stimulating hormone and pituitary extract, and interaction between primordial germ cell-like cells and testis supporting cells is enhanced by using small molecules SB431542, so that the meiosis of the testis is enhanced. And finally inducing to generate haploid sperm-like cells. According to the invention, a new tool can be provided for researching a molecular mechanism of male reproduction, and an important thought can be provided for research and transformation of asthenospermia, oligospermia, drug screening and the like.

This invention discloses a traditional Chinese medicine composition for treating male infertility due to liver stagnation and kidney deficiency, its preparation method, and its application, belonging to the fields of traditional Chinese medicine pharmaceutical technology and andrological reproductive health technology. The composition is formulated with Bupleurum chinense, Tribulus terrestris, Cynomorium songaricum, Cuscuta chinensis, Cornus officinalis, and Epimedium brevicornu in specific weight proportions, following the principles of soothing the liver and relieving stagnation, tonifying the kidney and replenishing essence, and unblocking the meridians to treat impotence. This invention employs an alcohol-water dual-phase fractional extraction process, and can be prepared into various dosage forms such as granules, capsules, and tablets. Pharmacological experiments have confirmed that the composition of this invention can increase sperm density and progressively motile sperm rate, improve penile tissue nitric oxide synthase (NOS) activity, regulate reproductive hormones, and reduce testicular oxidative damage; serum pharmacochemistry and metabolomics have clarified the active components entering the bloodstream and their pathways of action. This invention features a refined formulation, abundant medicinal resources, and simple preparation, making it suitable for large-scale production and clinical application in treating male infertility due to liver stagnation and kidney deficiency.

The invention relates to the technical field of biological medicines, and particularly discloses application of ebbeselenium in preparation of a medicine for treating male delayed gonadal hypofunction. After the ebbeselenium is adopted for intervention, the autophagy activity of testicular interstitial cells of old mice is increased, lipid autophagy is enhanced, testosterone synthesis is promoted, the serum testosterone level is remarkably improved, and the symptoms of male delayed hypogonadism (LOH) are effectively relieved; ebbeselenium simultaneously shows a relatively good delaying effect on senescence of a plurality of organs. The ebbeselenium can improve the reproductive capacity, the behavior memory capacity, the athletic capacity and the metabolic function of old mice at the same time, and synergistic and effective treatment of low serum testosterone and LOH complications is achieved. Besides, by enhancing the molecular reduction effect of PRDX1 targeting ATG4B, the ebbeselenium regulates and controls the autophagy pathway of testicular interstitial cells and enhances the functions of the testicular interstitial cells so as to promote synthesis of testosterone, and a new treatment strategy is provided for treatment of LOH.

A method of treating male hypogonadism in a subject in need thereof includes administering to the subject testicular organoids generated from isolated male progenitor cells. The method can be used to slow or halt the progression of age-related diseases, and increase healthspan and longevity, in hypogonadal males. The method can be used with subjects that have not or are not receiving testosterone replacement therapy. The method does not require that the subject is pre-treated with CG. The testicular organoid includes cells expressing GFRA1, VEGF, VEGFR2, PDGF-Rα, Cyp11A1, 3β-HSD, 17β-HSD, LHCGR, α-SMA, CD11b, MHC CII, CD64, CD95, Sox9, AR, inhibin β-B, and FSHR.

This invention provides a sauna testicular cover that can be stably placed on the seat of a sauna room and protect the user's testicles from excessive heat. [Solution] The sauna testicle cover comprises a bottom portion having a flat outer bottom surface, a wall portion that rises outward in a convex shape from around the bottom portion, and an opening formed at the upper end of the wall portion. This sauna testicle cover is configured to accommodate the user's testicles, which are received through the opening, inside the bottom portion and wall portion when the outer bottom surface is in contact with the seat surface of the sauna room. With this sauna testicle cover, the user's testicles can be protected from excessive heat while stably placed on the seat surface of the sauna room.

The invention provides an application of ergothioneine as a testis oxidative stress regulator. The invention provides a multi-target intervention method based on ergothioneine, which systematically improves sperm quality reduction caused by obesity by cooperatively regulating key links such as oxidative stress level, hormone secretion state and mitochondrial function. According to the invention, a safe and effective intervention effect with a clear action mechanism can be realized, and a new technical approach is provided for the treatment of obesity-related male reproductive dysfunction. The invention also provides application of the ergothioneine as the testicular steroid generation accelerant.

A lower body garment is disclosed having a sling assembly for securing male genitalia. The sling assembly is configured with limited, prescribed attachment points, which enables increased comfort and support, for the wearer. Moreover, the sling assembly provides a comfortable encapsulation that reduces the jostling of the testicles during athletic endeavors. The sling assembly configuration can further provide moisture management to reduce itching, chafing, and infection.

Disclosed herein are methods of reducing pathological inflammation and effects thereof through administration of tissues associated with regenerative and / or tolerogenic activity. In some embodiments, such tissues can include placental, ocular, testicular, and osseous tissues. Augmentation of therapeutic effects of said tissues may be achieved through contact with Injury Mimetics.

The invention belongs to the technical field of medicines, and particularly discloses application of afzelin in preparation of an anti-testis aging medicament, and testis aging resistance is particularly improvement or recovery of an aged testis tissue structure. The invention also provides a medicament for resisting testis aging. The medicament contains afzelin. The invention provides a new application of afzelin, the afzelin can be used for saving senescence testicular tissue structure disorder, remarkably reducing the epididymal sperm deformation rate and increasing the number of supporting cells and undifferentiated spermatogonium cells, the new application value of afzelin is developed, and a theoretical basis is provided for developing afzelin into anti-reproductive aging drugs.

The invention relates to the technical field of biomedicine, in particular to a construction method and application of a testis organ capable of differentiating sperms in vitro. The polypeptide hydrogel is used as a three-dimensional scaffold for testicular cell growth, and meanwhile, the testicular cell proliferation promoting liquid and the testicular cell differentiation promoting liquid are added in different culture stages, so that the construction of testicular organs is effectively realized. The obtained testis organs comprise testis seminiferous tubule structures consistent with those in vivo and various testis cells with the same arrangement mode; and in addition, spermatogonium can be successfully induced to differentiate deformed sperms in vitro. The testicular organ construction method provided by the invention is short in period, high in sperm differentiation success rate, simple and convenient to operate and low in cost. The constructed testis organ can be applied to screening of drugs or toxicants, testis ectogenesis models and clinical diagnosis and treatment, and has a wide application prospect and an important scientific value.

The application of unilateral or bilateral permanent prostheses to the labium majus in the external genitalia of women for reconstructive and aesthetic purposes may make it appear fuller. The labium majus may lose its fullness and symmetry due to menopause, rapid weight gain and loss, traumas, cancers, and infectious diseases. Aesthetic interventions (e.g., hyaluronic acid filler injection and fat grafting) aiming to provide the labium majus with fullness have become very popular in recent years. The hyaluronic acid filler is used for reconstructive purposes to achieve fullness in labium majus. However, the maximum amount that can be injected is 3 mL, which is often insufficient for the desired outcome and its effect lasts for a maximum of 1 year. Autologous fat grafting is administered by taking 18–120 mL of fat from patients themselves; however, its effect usually lasts 1 to 4 years. The application of a prosthesis will provide labium majus with fullness and this effect will be long-lasting. The outer edge of the prosthesis is convex and the inner edge is concave. In male genitalia, prostheses have been used since 1950 to provide the testicles with fullness. Scientific studies have shown that these prostheses positively affect self-confidence and body perception indices in men.

The utility model provides a portable testicular tissue sampling and freezing device, and belongs to the field of medical instruments. The sampling and freezing device comprises a sampling component, a freezing component and a freezing component, wherein the sampling component is used for sampling testicular tissues to be treated; the processing assembly is used for washing and fixing the testicular tissues sampled by the sampling assembly; the cooling assembly is used for cooling the testicular tissue treated by the treatment assembly; the freezing assembly is used for cryopreserving the testicular tissue cooled by the cooling assembly, and the sampling assembly, the processing assembly, the cooling assembly and the freezing assembly are all stored in a portable transfer box. According to the portable testicular tissue sampling and freezing device, the problem of emergency fertility preservation of soldiers can be solved, the device is portable, testicular tissue samples of rescued objects can be rapidly collected in time, and the testicular tissues can be rapidly frozen and stored for fertility preservation.

The application belongs to the field of regenerative medicine and nano drug delivery system, and particularly relates to a drug-loaded exosome for improving the testosterone secretion capacity of testicular interstitial cells and a preparation method and application thereof. The application links a targeting FATE1 polypeptide to the surface of MSC-derived exosomes by a chemical coupling method, and loads a small molecule compound in the exosomes by electroporation, so as to obtain modified MSC-derived exosomes. The obtained exosomes can obtain the targeting capacity in testicular interstitial cells, and the natural repair capacity of MSC-derived exosomes and the release of small molecule drugs promote the repair of damaged cells, improve the testosterone secretion capacity of testicular interstitial cells, and relieve male erectile dysfunction caused by diseases or aging.

We offer bifurcated pants that reduce sweating, stuffiness, odor, and itching. [Solution] A pair of bifurcated men's pants (trunks, briefs, boxer briefs, shorts, sportswear, swimming pants, swimwear, track and field pants, jerseys, volleyball pants, basketball pants, badminton pants, table tennis pants, gear shorts, bodysuit), consisting of a pant body, a third crotch pouch (for the testicles and penis) provided on the front of the pant body, and a tubular object, with the attachment angle set to 5 to 100 degrees from the pant body.

This utility model relates to a tissue separation device for spermatic vein ligation surgery, belonging to the field of male infertility surgery and medical devices. The separation device includes an intermediate pad with a central groove for accommodating a movable soft coil; hooks are provided on the opposite end face of the intermediate pad opposite the groove. The hooks bend downwards on both sides, effectively fixing the external spermatic fascia and cremaster muscle, fully exposing the surgical area. The silicone soft coil can be inserted between the blood vessels (testicular artery, pampiniform plexus) and the cremaster muscle, fully exposing the vessels to be ligated. The tissue separation device for spermatic vein ligation surgery provided by this utility model uses a medical-grade silicone soft coil, which has good biocompatibility, allows for flexible intraoperative operation, and its softness avoids damage to blood vessels.

The utility model relates to the technical field of medical equipment, in particular to an adjustable male testis radiotherapy fixator, which comprises a base, and a lifting mechanism is arranged at the bottom of the base and is matched with a lifting table; the first bracket is of a groove body structure, and one end of the first bracket is provided with a first supporting arm connected with the lifting table; the second bracket is matched with the top of the first bracket, and the second bracket is provided with a second support arm which is connected with the first support arm in an overlapping manner; corresponding semicircular grooves are formed in the ends, away from the lifting table, of the first bracket and the second bracket respectively, and the two semicircular grooves form a window communicated with the interior of the first bracket. Compared with a traditional body position type negative pressure bag fixing mode, the body position type negative pressure bag fixing device has the advantages of being accurate in positioning and high in comfort, testis can be fixed in the same effective position range every time, and therefore accurate radiotherapy is facilitated.

Prodrugs of testosterone and their use in alleviating, improving or reducing a risk of developing one or more conditions associated with androgen deprivation therapy (ADT), including orchiectomy or administration of a luteinizing hormone-releasing hormone agonist / antagonist, for the treatment of prostate cancer, including metastatic prostate cancer. In some aspects the prodrugs can be administered intranasally to target the central nervous system.