33 results about "Androstenone" patented technology

Disclosed is a method and a product of a chicory root product for reducing taint in animals, said method comprising feeding to an animal a chicory root product during at least one day prior to slaughtering the animal. By feeding animals with the chicory root product this improves the quality of meat, prevents or reduces female and male animal taint, primarily boar taint caused by skatole and/or androstenone. The invention also relates to methods for improving the health status of animals e.g. by reducing infections by pathogens in the gastrointestinal tract and to methods for reducing animal caused odors in general. The chicory root product comprises inulin/fructan (fructo-oligosaccharides), other low molecular weight sugars and secondary metabolites.

A perfume composition comprising a perfume component capable of inhibiting the production of odoriferous steroids by micro-organisms on the skin. The perfume component is capable of inhibiting the biotransformation of androstadienols to androstenones.

The invention discloses a fermentation process method for biologically synthesizing 7alpha,15alpha-dihydroxy androstenone by taking colletotrichum lini ST-1 as a strain. The method is characterized in that a certain amount of substrate dehydroepiandrosterone is added at the beginning of a fermentation process, and the substrate is fed again after the substrate dehydroepiandrosterone is cultured for a period of time, so that not only a key enzyme can be pre-induced in the transformation process, but also the toxicity to the strain cell caused by feeding the substrate at a time can be reduced. Therefore, the yield of the product can be increased. Through the adoption of the fermentation process, the 7alpha,15alpha-dihydroxy androstenone is synthesized, meanwhile, the feeding concentration of the substrate can reach 8 g/L (weight of substrate/volume of fermentation broth), and the transformation rate can reach about 90%. Compared with a once feeding way, the way of feeding the substrate reduces the toxicity to the cell caused by the substrate, increases the yield of the product to a certain extent, and increases the feeding amount of the substrate.

The invention belongs to the biotechnology field, and relates to a method for synthesizing novel 7alpha-hydroxy-androstenone (7alpha-OH-AD) steroid by the efficient utilization of colletotrichum lini ST-1 hydroxylation androstane-4-alkene-3, 17-diketone (AD). The method has the advantages that the conversion rate reaches up to 90% by adopting a two-step conversion method under the condition that the feeding amount of a substrate is 10g/L, and the total yield of the 7alpha-OH-AD product is 79.32%.

The invention discloses a spray for sows and a preparation method thereof. The spray can replace boars to be applied to estrus induction and check of sows and before and after breeding so as to prevent cross contamination of pigs in farms and prevent epidemic diseases. The spray comprises raw materials in parts by weight as follows: 1-5 parts of androstene substances, 1-5 parts of essence, 1-5 parts of lanolin, 1-5 parts of decavitamin, 1000-2000 parts of alcohol solvents, 1-9 parts of a cosolvent, 1-3 parts of an antioxidant and 10000-20000 parts of deionized water. The product can induce estrus of sows and effectively stimulate sexual reactions of sows to promote ovulation. Meanwhile, in the epidemic situation period, the traditional mode of estrus induction by boars can be avoided, so that spreading of epidemic situation is blocked.

The invention relates to a pheromone composition, in particular to a pheromone composition with an identification function and a preparation thereof. The pheromone composition comprises a component A,a component B and a component C, wherein the component A is androstenonev and/or androstanol; the component B comprises one or more of geraniol, tiglic aldehyde, palmitic acid, oleic acid, linoleic acid, capric acid, myristic acid, lauric acid and 3-methylindole; the component C comprises: a coloring agent. According to the method, multiple pheromones are combined for use, synergistic componentsfrom plants are added, the estrus rate and the reproductive success rate of the sows are increased, and meanwhile, the coloring agent is added for identification, so that the estrus identification efficiency is improved. Moreover, in the preparation process of the pheromone composition preparation, the androstanol is protected from being oxidized by filling nitrogen, so that the stability of the preparation is guaranteed, and the use of components such as an antioxidant and a preservative is avoided, and the product is safer and meets the green production requirement.

The invention discloses a preparation method of exemestane, relates to the field of an anti-cancer drug, and particularly relates to exemestane. The preparation method of the exemestane includes stepsof preparing 6-methylene androstenone glycol acetone; under the nitrogen protection, orderly adding paraformaldehyde, dimethylamine hydrochloride and isoamyl alcohol in a four-opening reaction bottle; heating and backflowing water for 2 hours; adding androstenone glycol acetone, preserving temperature and stirring at 140 DEG C; performing high performance liquid chromatography tracking detectionreaction; finishing reaction for 15 hours, and cooling to room temperature; adding distilled water to wash; after layering, drying it by anhydrous magnesium sulfate, depressurizing and recycling solvent; performing column chromatography on silica gel to obtain white solid; secondly, preparing exemestane; orderly adding 6-methylene androstenone glycol acetone, p-toluenesulfonic acid and tetrahydrofuran in a four-opening bottle under the nitrogen protection. The preparation method is simple in technical route, easy to obtain raw materials, low in cost, high in yield, and overcomes the defects existed in the prior art; therefore, the preparation method is applicable to industrial production.

The invention relates to a porcine transcription factor coup-tf1, its recombinant vector and application. The nucleotide sequence of the porcine transcription factor coup-tf1 is shown as SEQ ID NO.19. Overexpression of the porcine transcription factor coup-tf1 can reduce the expression of CYP11A1, CYP17A1 and StAR genes, lower the androstenone content in pork, inhibit the accumulation of odor substance, and ultimately improve the quality of the pork.

The invention relates to a pheromone composition, in particular to a pheromone composition spray preparation and a preparation method and application thereof. The pheromone composition spray preparation is prepared from the following components in percentage by mass: 0.001-0.02% of androstanone and/or androstanol, 0.001-0.02% of a herba epimedii extract, 0.2-20% of dimethyl sulfoxide, 0.01-0.5% oftween-80, 0.1-1.0% of a preservative, and 80.0-99.0% of purified water. The spray preparation is safer and more reliable, the reproductive performance (namely, the higher crossable estrus rate) of sows is reliably improved, the utilization rate of the sows is increased, and the fertility of the sows is improved.

The invention discloses a fermentation process method for biologically synthesizing 7alpha,15alpha-dihydroxy androstenone by taking colletotrichum lini ST-1 as a strain. The method is characterized in that hydrogen peroxide of certain concentration is flowingly added in the fermentation process to improve oxygen dissolving in the fermentation process and increase the yield of the product. By the fermentation process, the product 7alpha,15alpha-dihydroxy androstenone is synthesized, meanwhile, the feeding concentration of substrate can reach 8 g/L (weight of substrate/volume of fermentation broth), and the transformation rate can reach about 90%. By the method, the oxygen dissolving problem in the fermentation process can be solved better, and the expression of a key enzyme in the fermentation process is induced to a certain extent, so that the transformation efficiency is improved and the yield of the product is increased.

The invention relates to the field of medicine preparation, in particular to a synthetic method of androstenone. The preparation method comprises the following steps: S100, catalyzing testosterone by a catalyst, and carrying out hydrogenation addition reaction to obtain a compound I; S200, converting a 17-site hydroxyl group of the compound I into a halogen group or a sulfonate group which is easy to leave, so as to obtain a compound II; and S300, subjecting the compound II and alkali to an elimination reaction under the heating condition, namely, a dehalogenation reaction or a desulphonate reaction, so as to obtain androstenone. The synthesis method of androsteneone has the following beneficial effects: the raw materials are cheap and easy to obtain; the process is simple, the route is short, and the requirement on equipment is low; dangerous reagents and operation are avoided, and large-scale industrial production is easy to realize; and isomer impurities are not generated in the synthesis process, and the yield of the target product androsteneone is high.

The invention belongs to the technical field of steroid drug intermediates. The invention provides a preparation method of androst-2-ene-17-one, which comprises the following steps: 1) mixing epiandrosterone, a halogen-containing compound, a catalyst and a solvent, and performing halogenation reaction to obtain a compound 1; and 2) mixing the compound 1, a catalyst and a solvent, and performing elimination reaction to obtain androst-2-ene-17-one. By reasonably selecting the catalyst and controlling the raw material proportion and process conditions, the yield and purity of the target product are remarkably improved; and moreover, the reaction conditions are mild, the operation is simple, the production cost is low, and the reaction selectivity is good. The yield of the androst-2-ene-17-one prepared by the preparation method is greater than or equal to 94%, and the purity is greater than or equal to 98.5%.