A composition, employed topically for its microbicidal, spermatocidal activity upon application to the human genitalia and/or anorectal area, and the prophylaxis of sexually transmitted diseases, contraception, and the relief from symptoms of local inflamation and infection. The embodiment incorporates L-Ascorbic acid in a concentration of about 2% to about 25% wt/vol, within an acidic range or pH level of about 4.0 to 2.0 pH respectively, in an aqueous solution with a pharmaceutically acceptable liquid carrier. In alternative exemplary embodiments the composition is in a specified physical state and predetermined composition for the desired therapeutic effect. Additionally, the composition in alternative embodiment includes a synergistic antioxidant and further incorporates enhancing bioactive ingredients. The method for topical application of the composition includes douche, rinse, cream, gel, suppository, saturated tampon and externally saturated condom for treatment of the vagina; drops, spray, cleansing wipe, cream, gel and internally saturated condom for treatment of the penis; and cleansing wipe, gel, suppository and externally saturated condom for male genitalia and rectum.