The invention relates to a health care wine, which is prepared by infusion of the following Chinese herbal medicines by weight: 18-45 parts of ganoderma lucidum, 18-45 parts of maca, 2-8 parts of ginseng, 2-8 parts of Chinese wolfberry, 2-8 parts of mulberry, 2-8 parts of cordyceps militaris, 2-8 parts of polygonatum odoratum, and 2-8 parts of raspberry. The preparation method includes the steps of: crushing, infusion, filtration, clarification and blending. The health care wine provided by the invention has the efficacy of nourishing yin and reinforcing kidney, benefiting qi and activating blood, replenishing blood and keeping beauty, removing toxin and moistening dryness, has the effects of delaying senescence, maintaining beauty and keeping youth, prolonging life, and improving reproductive health, and has the pharmacological action of boosting body immunity, resisting oxidative damage, lowering blood glucose and blood fat, dilating blood vessels, and improving circulation, etc., is safe and reliable for taking, and has no side effect after long-term taking. The nutritional ingredients are organically combined, and soy peptide powder is added to greatly improve the absorption efficiency of human body to nutritional ingredients and improve the body circulation.