Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of cr-wpi in the treatment of erectile dysfunction

A technology for erectile dysfunction and oxidative stress response, applied in the field of biomedicine, can solve problems such as the treatment effect of CR-WPI on erectile dysfunction that has not been reported, and achieve the effects of improving erectile function, reducing apoptosis and reducing damage

Active Publication Date: 2022-04-22
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no existing studies have reported the therapeutic effect of CR-WPI on erectile dysfunction

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of cr-wpi in the treatment of erectile dysfunction
  • Application of cr-wpi in the treatment of erectile dysfunction
  • Application of cr-wpi in the treatment of erectile dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Experimental method

[0022] 1. Experimental animals

[0023] Forty-eight 8-week-old male Sprague Dawley rats, weighing 230-250 g, were provided by the Experimental Animal Center of Shandong University. (The Animal Care and Use Committee of Shandong University (Jinan, China) approved and assisted in all experimental procedures of animal experiments).

[0024] 2. Experimental method

[0025] Rats were individually housed in a specific pathogen-free environment at an ambient temperature of 22–24°C. All animals were acclimatized to a 12-h light-dark cycle for one week with ad libitum access to food and water. To induce diabetes, 40 rats received a single intraperitoneal injection of 60 mg kg-1 streptozotocin (STZ, Sigma-Aldrich, St. Louis, MO) after a 12-hour fast. The remaining 8 rats were only injected with the same amount of citrate buffer as the sham operation group. Animals with blood glucose levels consistently above 16.7 mmol-1 after 72 hours of continuous m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the application of CR-WPI in treating erectile dysfunction, CR-WPI (cysteine-rich whey protein) can reduce oxidative stress by increasing the content of endogenous glutathione, regulate DDAH / ADMA / NOS pathway inhibits the apoptosis of corpus cavernosum smooth muscle cells (CCSMC), thereby improving erectile function.

Description

technical field [0001] The invention relates to the application of CR-WPI in treating erectile dysfunction, and belongs to the field of biomedicine. Background technique [0002] The incidence of erectile dysfunction (ED) is high, and the incidence rate is as high as 50% in men over 40 years old. Among them, patients with severe erectile dysfunction do not respond well to traditional PDE5 inhibitors. Diabetes mellitus (DM) is one of the most common risk factors for severe erectile dysfunction, and patients with diabetic erectile dysfunction (DMED) have a certain tolerance to PDE-5 inhibitors, the current first-line drugs for the treatment of erectile dysfunction. Accumulating evidence indicates that oxidative stress plays an important role in the formation and progression of DMED. Studies have shown that antioxidants can reduce the production of ROS and improve endothelial function in diabetes-related ED, indicating that antioxidant therapy plays an important role in improv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P15/10A61P15/00
CPCA61K38/1709A61P15/10A61P15/00
Inventor 刘帅
Owner SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com