Application of cr-wpi in the treatment of erectile dysfunction

A technology for erectile dysfunction and oxidative stress response, applied in the field of biomedicine, can solve problems such as the treatment effect of CR-WPI on erectile dysfunction that has not been reported, and achieve the effects of improving erectile function, reducing apoptosis and reducing damage
CN113350485BActive Publication Date: 2022-04-22SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN ¡ China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
Publication Date
2022-04-22

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Abstract

The invention discloses the application of CR-WPI in treating erectile dysfunction, CR-WPI (cysteine-rich whey protein) can reduce oxidative stress by increasing the content of endogenous glutathione, regulate DDAH / ADMA / NOS pathway inhibits the apoptosis of corpus cavernosum smooth muscle cells (CCSMC), thereby improving erectile function.
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Description

technical field

[0001] The invention relates to the application of CR-WPI in treating erectile dysfunction, and belongs to the field of biomedicine. Background technique

[0002] The incidence of erectile dysfunction (ED) is high, and the incidence rate is as high as 50% in men over 40 years old. Among them, patients with severe erectile dysfunction do not respond well to traditional PDE5 inhibitors. Diabetes mellitus (DM) is one of the most common risk factors for severe erectile dysfunction, and patients with diabetic erectile dysfunction (DMED) have a certain tolerance to PDE-5 inhibitors, the current first-line drugs for the treatment of erectile dysfunction. Accumulating evidence indicates that oxidative stress plays an important role in the formation and progression of DMED. Studies have shown that antioxidants can reduce the production of ROS and improve endothelial function in diabetes-related ED, indicating that antioxidant therapy plays an important role in improv...

Claims

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