Application of cr-wpi in the treatment of erectile dysfunction

A technology for erectile dysfunction and oxidative stress response, applied in the field of biomedicine, can solve problems such as the treatment effect of CR-WPI on erectile dysfunction that has not been reported, and achieve the effects of improving erectile function, reducing apoptosis and reducing damage

Active Publication Date: 2022-04-22
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no existing studies have reported the therapeutic effect of CR-WPI on erectile dysfunction

Method used

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  • Application of cr-wpi in the treatment of erectile dysfunction
  • Application of cr-wpi in the treatment of erectile dysfunction
  • Application of cr-wpi in the treatment of erectile dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Experimental method

[0022] 1. Experimental animals

[0023] Forty-eight 8-week-old male Sprague Dawley rats, weighing 230-250 g, were provided by the Experimental Animal Center of Shandong University. (The Animal Care and Use Committee of Shandong University (Jinan, China) approved and assisted in all experimental procedures of animal experiments).

[0024] 2. Experimental method

[0025] Rats were individually housed in a specific pathogen-free environment at an ambient temperature of 22–24°C. All animals were acclimatized to a 12-h light-dark cycle for one week with ad libitum access to food and water. To induce diabetes, 40 rats received a single intraperitoneal injection of 60 mg kg-1 streptozotocin (STZ, Sigma-Aldrich, St. Louis, MO) after a 12-hour fast. The remaining 8 rats were only injected with the same amount of citrate buffer as the sham operation group. Animals with blood glucose levels consistently above 16.7 mmol-1 after 72 hours of continuous m...

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PUM

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Abstract

The invention discloses the application of CR-WPI in treating erectile dysfunction, CR-WPI (cysteine-rich whey protein) can reduce oxidative stress by increasing the content of endogenous glutathione, regulate DDAH / ADMA / NOS pathway inhibits the apoptosis of corpus cavernosum smooth muscle cells (CCSMC), thereby improving erectile function.

Description

technical field [0001] The invention relates to the application of CR-WPI in treating erectile dysfunction, and belongs to the field of biomedicine. Background technique [0002] The incidence of erectile dysfunction (ED) is high, and the incidence rate is as high as 50% in men over 40 years old. Among them, patients with severe erectile dysfunction do not respond well to traditional PDE5 inhibitors. Diabetes mellitus (DM) is one of the most common risk factors for severe erectile dysfunction, and patients with diabetic erectile dysfunction (DMED) have a certain tolerance to PDE-5 inhibitors, the current first-line drugs for the treatment of erectile dysfunction. Accumulating evidence indicates that oxidative stress plays an important role in the formation and progression of DMED. Studies have shown that antioxidants can reduce the production of ROS and improve endothelial function in diabetes-related ED, indicating that antioxidant therapy plays an important role in improv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P15/10A61P15/00
CPCA61K38/1709A61P15/10A61P15/00
Inventor 刘帅
Owner SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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