The invention relates to a computational simulation method of a flow slide catastrophe of a rock and soil material, belonging to the technical fields of computational rock and soil mechanics, geologic hazard prevention and control and geologic environment protection. Aiming at the limitation that the conventional grid-based computing method is only suitable for small-deformation analysis, the invention discloses a computational simulation method of an entire flow slide catastrophe process of the rock and soil material based on smoothed particle hydrodynamics (SPH). According to the method, a Navier-strokes equation is used as a control equation, solid phase and liquid phase of the rock and soil material are described by using a sub-load face Cambridge model and an incompressible fluid constitutive model respectively, porous medium theory and darcy law are introduced to calculate solid-liquid coupling acting force, and a computation model, which considers the full coupling of water and soil, of the flow slide catastrophe of the rock and soil material, is established. According to the computational simulation method, the entire process of large-deformation flow damage of the rock and soil material can be effectively represented, and the fluidization characteristic of the rock and soil material is captured, so that powerful scientific basis is provided for engineering design, engineering construction, disaster prevention and reduction and the like of high-risk areas of the flow slide disaster, and meanwhile, application of the computational rock and soil mechanics in the technical fields of actual engineering construction, geologic hazard prevention and control and the like is forcefully promoted.