The invention discloses a multiple combination optimization overhead transmission line operation risk informatization assessment method which comprises the steps that 1. risk identification is carried out, wherein by data collecting, a fault source is found, a risk accident set is generated, an uncertain risk factor set is analyzed in a statistic mode, and a risk evaluation index system is established; 2. an integrated risk value is determined, a transmission line operation risk assessment model is established, information entropy and an analytic hierarchy process are fused, risk probability, consequences generated by risks and risk weight are considered in a comprehensive mode, risk consequence severity is quantized through a mutual information value, and a transmission line operation integrated risk value is computed in a layer-by-layer-reasoning mode and a multiple-combination mode; and 3. risk determining is carried out, risk grades are divided, analyzing is carried out on the integrated risk weight, the risk grades are determined, and the results of risk assessment are output. According to the method, the overhead transmission line operation risk is assessed in a comprehensive mode and a multilevel mode, and the accuracy of transmission line operation risk assessment and the reliability of transmission line operation are improved.