Lanthanide rare earth coordinated cellulose medical material and preparation method thereof

A lanthanide rare earth and cellulose technology, applied in the field of medical materials, can solve the problems of low adsorption efficiency and stability of bactericides, no antibacterial function, harmful microorganism pollution, etc., achieve good degradability, and broaden the scope of clinical application , good antibacterial performance

Active Publication Date: 2015-01-14
山东省医疗器械研究所
View PDF6 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natural biocellulose medical materials themselves do not have antibacterial function, and are easily polluted by harmful microorganisms in the air or water, causing a series of infection problems
At present, the cellulose is placed in the fungicide solution by soaking and adsorbing to make the cellulose have antibacterial function, but the adsorption efficiency and stability of the fungicide are not high, and the bactericidal effect is poor.
[0003] The Chinese patent application number is 01126953.7 and the patent application publication number is CN1338475A discloses "Preparation method of medical absorbable oxidized regenerated cellulose hemostatic material". The material has good hemostatic and absorption capacity, but the material itself does not have antibacterial function. It cannot be used alone, it needs to be used in combination with other antibacterial drugs to have a hemostatic effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] The present invention also relates to a preparation method of lanthanide rare earth coordination cellulose medical material, the steps are as follows:

[0024] (1) Using an oxidizing agent to oxidize the primary hydroxyl group of cellulose into a carboxyl group to obtain cellulose sodium salt, soak the cellulose sodium salt with 0.1-1 mol / L hydrochloric acid to obtain cellulose salt;

[0025] (2) Dissolve cellulose salt in an organic solvent, add lanthanide rare earth metal hydrate and stir to dissolve, wherein the mass ratio of cellulose salt and rare earth metal hydrate is 1~3:1, heat to reflux, and perform sol-gel Glue self-assembly reaction, the reaction time is 2-4 hours, and the reaction solution is obtained. The lanthanide rare earth metal hydrate is lanthanide rare earth ion halide hexahydrate, lanthanide rare earth ion nitrate hexahydrate or lanthanide rare earth ion Any of the sulfate hexahydrates;

[0026] (3) Filter the reaction solution in step (2), then w...

Embodiment 1

[0035] Put 50mg TEMPO and 500mgNaBr into a container, add 200ml of water to the container, then add 20g of bacterial cellulose, then dropwise add 25ml of NaClO solution, react at 4°C, adjust the pH value of the reaction solution to 10.8 with 0.4 mol / L NaOH solution, React for 2 hours, add 5ml of ethanol to terminate the reaction, then pour the reaction solution into ethanol, filter out the white precipitate, wash 3 times with an ethanol aqueous solution with a volume ratio of ethanol and water of 7:3 to obtain bacterial cellulose sodium salt, and use 0.1 mol The HCl solution soaking treatment of / L obtains bacterial cellulose salt, and the available chlorine content of described NaClO solution is 10%, and described bacterial cellulose is the water-containing film material of fermentation, contains bacterial cellulose and water, wherein the bacterial cellulose The mass fraction is 10%, and the mass fraction of water is 90%;

[0036] Dissolve 3g of bacterial cellulose salt ...

Embodiment 2

[0040] Weigh 10g of cotton fiber and add 50g of 5% NaOH solution, mercerizing treatment for 1 hour, then repeatedly rinse with deionized water and neutralize with 10% acetic acid solution, then wash with deionized water until neutral, suction filter and set aside.

[0041] Put 50mg TEMPO and 480g NaBr into a container, add 150ml of water into the container, then add 8g of the above-mentioned mercerized cotton fiber, then add 20ml of NaClO solution dropwise, react at 4°C, and adjust the pH value of the reaction solution to 10.5, react for 2 hours, add 5ml of ethanol to terminate the reaction, then pour the reaction solution into ethanol, filter out the white precipitate, wash 3 times with ethanol and water ethanol aqueous solution with a volume ratio of 7:3 to obtain cotton cellulose sodium salt, use The HCl solution soaking treatment of 0.2mol / L obtains cotton cellulose salt, and the available chlorine content of described NaClO solution is 10%;

[0042] Take 6g of cotton cell...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a lanthanide rare earth coordinated cellulose medical material and a preparation method thereof. The medical material is prepared by oxidizing primary hydroxyl of cellulose into carboxyl and then coordinating with lanthanide rare earth metal ions, namely performing sol-gel self-assembling reaction to rare earth metal hydrate and cellulose the primary hydroxyl of which is selectively oxidized into carboxyl. The preparation method is simple in preparation technology and good in controllability. The material not only has excellent moisture absorption and preservation properties and breathability, and better biocompatibility and excellent degradability of cellulose materials, but also has antibacterial property of the rare earth complex, can be used for antibacterial and bacteriostasis wound dressing due to broad-spectrum antibacterial property, and can also be used for detection tracing, special marking and optical display of biomolecules; the lanthanide rare earth coordinated cellulose medical material can be prepared into powder, gel, thin films, sponge or other porous materials, thus expanding the clinical application range; and the lanthanide rare earth coordinated cellulose medical material can be doped or grafted with macromolecular compounds so as to enhance the antibacterial and bacteriostasis properties and promote therapeutic effect on wound recovery.

Description

technical field [0001] The invention relates to medical materials, in particular to a lanthanide rare earth coordination cellulose medical material and a preparation method thereof. Background technique [0002] At present, biomedical materials are divided into synthetic polymers and natural polymer materials, among which natural polymer materials are widely used because of their good biocompatibility and degradability, such as natural biocellulose medical materials. However, natural biocellulose medical materials themselves do not have antibacterial function, and are easily polluted by harmful microorganisms in the air or water, causing a series of infection problems. At present, the cellulose is placed in the fungicide solution by soaking and adsorbing to make the cellulose have antibacterial function, but the adsorption efficiency and stability of the fungicide are not high, and the bactericidal effect is poor. [0003] The Chinese patent application number is 01126953.7...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08B15/05C08B15/02C08B15/00A61L15/28A61L15/44A61L15/42
Inventor 王晓晨郈秀菊李红梅
Owner 山东省医疗器械研究所
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap