Lanthanide rare earth coordinated cellulose medical material and preparation method thereof

Abstract

The invention discloses a lanthanide rare earth coordinated cellulose medical material and a preparation method thereof. The medical material is prepared by oxidizing primary hydroxyl of cellulose into carboxyl and then coordinating with lanthanide rare earth metal ions, namely performing sol-gel self-assembling reaction to rare earth metal hydrate and cellulose the primary hydroxyl of which is selectively oxidized into carboxyl. The preparation method is simple in preparation technology and good in controllability. The material not only has excellent moisture absorption and preservation properties and breathability, and better biocompatibility and excellent degradability of cellulose materials, but also has antibacterial property of the rare earth complex, can be used for antibacterial and bacteriostasis wound dressing due to broad-spectrum antibacterial property, and can also be used for detection tracing, special marking and optical display of biomolecules; the lanthanide rare earth coordinated cellulose medical material can be prepared into powder, gel, thin films, sponge or other porous materials, thus expanding the clinical application range; and the lanthanide rare earth coordinated cellulose medical material can be doped or grafted with macromolecular compounds so as to enhance the antibacterial and bacteriostasis properties and promote therapeutic effect on wound recovery.

Description

technical field [0001] The invention relates to medical materials, in particular to a lanthanide rare earth coordination cellulose medical material and a preparation method thereof. Background technique [0002] At present, biomedical materials are divided into synthetic polymers and natural polymer materials, among which natural polymer materials are widely used because of their good biocompatibility and degradability, such as natural biocellulose medical materials. However, natural biocellulose medical materials themselves do not have antibacterial function, and are easily polluted by harmful microorganisms in the air or water, causing a series of infection problems. At present, the cellulose is placed in the fungicide solution by soaking and adsorbing to make the cellulose have antibacterial function, but the adsorption efficiency and stability of the fungicide are not high, and the bactericidal effect is poor. [0003] The Chinese patent application number is 01126953.7...

AI Technical Summary

Problems solved by technology

However, natural biocellulose medical materials themselves do not have antibacterial function, and are easily polluted by harmful microorganisms in the air or water, causing a series of infection problems

At present, the cellulose is placed in the fungicide solution by soaking and adsorbing to make the cellulose have antibacterial function, but the adsorption efficiency and stability of the fungicide are not high, and the bactericidal effect is poor.

[0003] The Chinese patent application number is 01126953.7 and the patent application publication number is CN1338475A discloses "Preparation method of medical absorbable oxidized regenerated cellulose hemostatic material". The material has good hemostatic and absorption capacity, but the material itself does not have antibacterial function. It cannot be used alone, it needs to be used in combination with other antibacterial drugs to have a hemostatic effect