31results about How to "Rapid gelation" patented technology

The invention provides temperature-sensitive chitosan-carboxymethylcellulose gel and a preparation method and application thereof. The temperature-sensitive chitosan-carboxymethylcellulose gel is prepared by physically crosslinking the chitosan and sodium carboxymethylcellulose at the temperature of 10 DEG C or below. The gel system has rapid temperature-sensitive response performance and can be kept in a liquid state at room temperature or when the temperature is lower than room temperature, and gelatinization can be rapidly realized when the temperature reaches body temperature. The gel preparation method is simple and practicable in operation, the reaction conditions are mild, and organic chemical reagents or other harmful substances can be avoided. The prepared temperature-sensitive gel is suitable for industries such as medicine products, skin care products and foods.

The invention belongs to the field of polymer composite hydrogel, and relates to an injectable and rapidly-gelatinized composite hydrogel and a preparation method thereof, wherein the composite hydrogel is formed by crosslinking a water-soluble polymer with an amino group and a water-soluble polymer with an aldehyde group; the composite hydrogel has the pH response characteristics and injectability; the composite hydrogel forms a three-dimensional network structure through the interaction between the amino group and the aldehyde group, various drugs or growth factors and other bioactive molecules can be loaded in the three-dimensional network structure. In addition, the composite hydrogel has injectability, and because the carbon-nitrogen double bond Schiff base linking structure formed bythe amino group and the aldehyde group has pH response characteristics, the composite hydrogel can be used as a polymer hydrogel wound dressing having certain application prospects in the fields of drug releasing, skin wound repair and the like.

The invention discloses a star-type polylactic acid-polyethylene glycol monomethyl ether copolymer. The preparation method of the star-type polylactic acid-polyethylene glycol monomethyl ether copolymer comprises the following steps of: initiating lactide to carry out ring opening polymerization to form star-type polylactic acid by using propanetriol or pentaerythritol as an initiator, adding organic base and a basic catalyst by using butanedioic anhydride as an acylating agent and dimethyl sulfoxide as a solvent and carrying out carboxylation on the tail end of the star-type polylactic acid;adding the star-type polylactic acid of which the tail end is subjected to carboxylation in an organic solvent; then adding the polyethylene glycol monomethyl ether, a condensing agent and a catalystfor reacting; and after the reacting, filtering, dissolving a product in water and gradually raising the temperature until precipitation is generated and obtaining the star-type polylactic acid-polyethylene glycol monomethyl ether copolymer. The hydrogel disclosed by the invention is in a solution state at normal temperature or at the temperature lower than normal temperature and can be quickly gelated at 37DEG C; the formed hydrogel can be degraded in the body and has favorable biocompatibility; and the invention has the advantages of simple synthetic method, mild reaction conditions and suitability for industrial production.

The present invention relates to composition(s) comprising collagen, calcium ions and alginate, wherein the composition polymerizes in situ when contacted with blood. The composition may further comprise an erythrocyte aggregation agent and / or a platelet activation agent. The composition may be formulated into two separate formulations. The first formulation comprises collagen in a calcium-containing solution and a second formulation comprises an aqueous alginate solution. The two formulations can be mixed prior to the contact with blood or mixed coincident with the contact with blood.

A method for preparing a hydrogel material based on 1,4-cyclohexane / phthalic acid belongs to the technical field of hydrogel materials and comprises the following steps: (1) the 1,4-cyclohexane / phthalic acid SDiAc carries out chlorination reaction with sulfoxide chloride SOCl2 to generate SDiAcCl; (2) 1 part of SDiAcCl prepared in the step (1) is taken to carry out amidation reaction with 2.2 parts of amino acid (NH2RCOCH3) under methyl protection to generate SDiAcNHRCOCH3 and then methyl protection is removed to generate SDiAcNHRCOOH; and (3) 1 part of SDiAcNHRCOOH prepared in the step (2) is taken to carry out acylation reaction with 2.2 parts of compound molecules containing amino groups or hydroxyl groups (Y) to generate the hydrogel material SDiAcNHRCOY. The preparation method is simple and convenient, and the obtained hydrogel has good biocompatibility and is degradable.

The invention provides a nanogel hemostatic material modified with modified glucan as well as preparation and an application of the nanogel hemostatic material. The nanogel hemostatic material is formed by polymerizing modified glucose and monomers containing vinyl, wherein the modified glucose is glucose modified with glycidyl methacrylate. The nanogel hemostatic material has excellent water absorption and good biocompatibility, the size is increased after the nanogel hemostatic material absorbs water to expand, a polymer hydrogel layer is formed and can block a wound to stop bleeding, modified glucan nonogel has an excellent hemostatic effect on traumatic hemorrhage such as venous hemorrhage, arterial hemorrhage, body surface hemorrhage as well as internal organ hemorrhage such as liver hemorrhage, is a good and novel hemostatic and has good application prospects in clinical trauma. The invention further provides a preparation method of the modified polysaccharide modified nanogel hemostatic material. The raw materials are cheap and easy to obtain, the reaction condition is mild, the reaction operation is simple, and post-treatment is convenient.

The invention discloses hydrogel with multiple response function and a preparation method and application thereof; the preparation method of the hydrogel comprises the steps of adding hydrogel material, acryloyl chloride and triethylamine into a solvent, and reacting under ice bath to obtain modified hydrogel material; adding diselenide-diol, acryloyl chloride and triethylamine into a solvent, reacting under ice bath to obtain modified diselenide with C-C double bond; mixing the modified hydrogel material solution with the modified diselenide solution, adding a photo-polymerization initiator, and irradiating in ultraviolet at 20-40 DEG C to generate hydrogel having multiple response function. The hydrogel material is responsive to temperature, light and redox, quick gelling can be achieved by adjusting temperature, bulk concentration, photo-polymerization initiator concentration and a light source, the hydrogel is easy to form and has excellent mechanical properties and biocompatibility, and redox responsiveness of the hydrogel helps load different drug molecules and release them effectively.

The invention discloses a nano hybrid silk fibroin hydrogel and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The nano hybrid silk fibroin hydrogel is prepared by pre-blending a regenerated silk fibroin aqueous solution and nano hydroxyapatite and performing ultrasonic treatment. According to the preparation method of the nano hybrid silkfibroin hydrogel, the ultrasonic condition and the mixing ratio of the two materials are changed, the gelation time is controlled, and rapid gelation is realized, so that use of a potentially toxic chemical crosslinking agent is avoided, and activity of cells or biological factors can be well maintained. The nano hybrid silk fibroin hydrogel provided by the invention has controllable gel performance, controllable mechanical performance, good cell compatibility and good bone induction capability, can load stem cells for repairing bone defect, and is expected to be used for embedding active factors for synergistic treatment.

The invention belongs to the technical field of functional materials, and relates to multi-functional hydrogel triggered by lignin phenolic resin silver-loaded nano spheres as well as a preparation method and application thereof. The preparation method of the multi-functional hydrogel containing the lignin phenolic resin silver-loaded nano spheres comprises the following steps: (1) preparing the lignin phenolic resin silver-loaded nano spheres: dissolving lignin, phenol, formaldehyde and sodium hydroxide in water, carrying out hydrothermal curing, and carrying out centrifugal drying on the obtained solution to obtain lignin phenolic resin nano spheres; and adding the obtained lignin phenolic resin nano spheres into a silver-ammonia solution, stirring at the room temperature, and carrying out centrifugal drying to obtain the lignin phenolic resin silver-loaded nano spheres. and (2) preparing the multi-functional hydrogel: uniformly mixing and stirring the obtained lignin phenolic resin silver-loaded nano spheres and ferric trichloride hexahydrate in water, then adding an initiator and a cross-linking agent, and standing at the room temperature to obtain the multi-functional hydrogel. The problems of complex hydrogel forming conditions and single function in the prior art are solved.

The invention provides a hole sealing material for karst water inflow and further correspondingly provides a preparation method and hole sealing method thereof. The hole sealing material comprises, byweight, 70-90 parts of portland cement, 10-15 parts of coal ash, 10-20 parts of bentonite, 0.05-0.16 part of sodium carboxymethyl cellulose, 15-40 parts of water, 3-5 parts of water glass and 1-2 parts of hemp thread. The hole sealing material is sufficiently kneaded, can be quickly solidified, has the advantages of good water stability, dispersion resistance, durability, high strength and the like, helps to lower the cost, improve the construction quality and make water plugging construction more convenient, achieves the aim of efficient hole sealing, and is suitable for hole sealing operation in a high-pressure water-rich karst area. The preparation method and hole sealing method of the hole sealing material are easy to operate, less in equipment input and low in cost, cause no pollution to the environment, and can guarantee the hole sealing effect and improve the hole sealing efficiency.

The invention discloses the preparation and application of a near-infrared photopolymerizable injectable hydrogel, which is a methacryloyl carboxymethyl chitosan solution with double bonds introduced under near-infrared light, and the modified hydrogel prepared above Gold nanorods, 4ARM‑PEGSH, and VAZO44 solutions are added with the required amount of antineoplastic drugs. The hydrogel is obtained by near-infrared photopolymerization, and after being injected into the tumor site, a photothermal treatment can be completed. When near-infrared photopolymerized hydrogels are obtained in vivo, antitumor drugs can be chemotherapeutic through sustained release. In this way, the combined treatment of photothermal + chemotherapy can be completed to achieve the purpose of treating tumors.

The invention belongs to the technical field of food, and relates to a method for processing noodles, and the noodles. The method for processing the noodles comprises the following steps: mixing and pretreating rice starch, waxy corn starch and pectin, and conducting high static pressure treatment on the mixture to obtain a mixed starch solution; adding the mixed starch solution and water to flour, conducting dough kneading, the resting and strip cutting to obtain pretreated noodles; and subjecting the pretreated noodles to a first cold treatment, a heat treatment, a secondary cold treatment,and drying to obtain the noodles. The method significantly improves the taste of the noodles by selecting the raw materials and specific processing technology, realizes the preparation of the high-quality noodles, and achieves the beneficial effects of enhancing chewy mouthfeel of the noodles, reducing sticky soup during a cooking process, and reducing cooking loss rate.

The invention provides facial mask powder. The facial mask powder comprises, by weight, 28-33 parts of edible tulip root, 20-23 parts of xanthium fruits, 10-14 parts of radix angelicae, 16-20 parts ofbletilla striata, 3-5 parts of lithargite, 8-11 parts of rhizoma chuanxiong, 3-5 parts of oligochitosan, 4-8 parts of radix angelica sinensis extracts, 3-6 parts of chinaroot greenbrier extracts, 21-25 parts of Acai berry extracts, 4-9 parts of polygala tenuifolia extracts, 30-39 parts of lettuce seed powder, 33-38 parts of wheat gluten, 28-30 parts of silk fibroin, 10-12 parts of locust bean gum, 8-11 parts of carrageenan, 38-45 parts of seaweed gel and 33-36 parts of inulin. The facial mask powder has a good acne removing effect and can effectively prevent formation of whelks.

The invention discloses a starch-based hemostatic material with a time series hemostatic effect and a preparation method thereof. The starch-based hemostatic material is a hydrogel dosage form formedby a modified starch solution under the catalysis of hydrogen peroxide and catalase. The preparation reaction is carried out under homogeneous conditions, and the problems of high reaction conditionsand low degree of substitution in previous heterogeneous reactions are solved. The preparation process is simple and a preparation cycle is short. The prepared starch-based hemostatic gel can rapidlygelate in case of wound and effectively block the wound, then adheres to activate blood cells and coagulation factors, and then activates a coagulation system, so as to achieve the rapid time series hemostatic effect and promote the wound healing effect. The starch-based hemostatic material is a hemostatic material with broad application prospects.

The invention discloses an autoclaved sand-lime brick and a preparation method thereof. According to the invention, a high-water-absorbing resin material is added to preparation raw materials of an autoclaved sand-lime brick so as to improve the water absorption of the autoclaved sand-lime brick and reduce the brittleness of the autoclaved sand-lime brick, and the high-water-absorbing resin has the performance of absorbing water at high temperature and removing water at low temperature and is resistant to high pressure, so that the technical problems that an existing autoclaved sand-lime brick is unstable in shrinkage and prone to cracking after being discharged out of a furnace are solved.

The invention belongs to the technical field of functional materials, and relates to a multifunctional hydrogel triggered by lignin phenolic resin-loaded silver nanospheres, a preparation method and application thereof. The preparation method of the multifunctional hydrogel containing the lignin-phenolic resin-loaded silver nanospheres includes: (1) the preparation method of the lignin-phenolic resin-loaded silver nanospheres. Dissolving lignin, phenol, formaldehyde and sodium hydroxide in water, after hydrothermal curing, centrifuging and drying the obtained solution to obtain lignin phenolic resin nanospheres; adding the obtained lignin phenolic resin nanospheres to silver ammonia solution, stirring at room temperature Centrifugal drying to obtain lignin phenolic resin-loaded silver nanospheres. (2) The preparation method of the multifunctional hydrogel. The obtained lignin phenolic resin-loaded silver nanospheres and ferric trichloride hexahydrate are mixed and stirred uniformly in water, then an initiator and a crosslinking agent are added, and the multifunctional hydrogel can be obtained by standing at room temperature. The problem of complex transaction conditions and single function of hydrogel in the prior art is solved.

The invention discloses a method for preparing a super-hydrophobic microporous membrane by synergistically regulating phase separation with an aqueous inorganic salt solution. In the casting liquid system composed of polymer / solvent / additive, weak non-solvent is beneficial to polymer crystallization, strong non-solvent is conducive to rapid gelation and the formation of large cavities, and inorganic salt grains nucleate and cause pores By using the advantages of the three agents, they play a synergistic role in the liquid phase separation process of the cast membrane, and prepare a homogeneous superhydrophobic microsphere structure membrane with good pore connectivity. The surface of the microsphere structure has a nano-scale papillae structure when the polymer is solidified, thereby forming a super-hydrophobic micro-nano structure on the surface of the membrane like a lotus leaf. The membrane body is completely composed of a microsphere structure, and the membrane pores have good connectivity. and hydrophobicity, thereby improving the stability and durability of the hydrophobic microporous membrane.

The invention discloses a medical eye patch used for infants and children. The medical eye patch comprises an anti-sticking layer (1), a micro-needle array layer (2), an eye medicine storage layer (3)and a sticking layer (4). The invention also discloses a preparation method and a purpose of the medical eye patch. The medical eye patch is simple in use and preparation, and does not hurt the eyesof infants and children.

The invention discloses a two-component superhydrophobic polyurethane ring adhesive activated by ultraviolet rays, which includes two components A and B, wherein component A is a hydrophobic polyurethane prepolymer; component B is composed of the following components as follows: Mixed by mass ratio: 85-97% macromolecular hydrophobic polyol, 1-10% organic fluorosilicon modified phosphate ester, 1-5% photobase generator, 0.001%-0.5% defoamer, each component And meet 100%; the ring glue mixed with A and B components has a very good adhesion to optical fiber and metal, and the operation time at room temperature is long, and the curing activity can be activated under the irradiation of ultraviolet light, and the rapid curing can be achieved in 5-30 minutes. Gel, realize the flexible operation of the ring glue.

The invention discloses hydrogel with multiple response function and a preparation method and application thereof; the preparation method of the hydrogel comprises the steps of adding hydrogel material, acryloyl chloride and triethylamine into a solvent, and reacting under ice bath to obtain modified hydrogel material; adding diselenide-diol, acryloyl chloride and triethylamine into a solvent, reacting under ice bath to obtain modified diselenide with C-C double bond; mixing the modified hydrogel material solution with the modified diselenide solution, adding a photo-polymerization initiator, and irradiating in ultraviolet at 20-40 DEG C to generate hydrogel having multiple response function. The hydrogel material is responsive to temperature, light and redox, quick gelling can be achieved by adjusting temperature, bulk concentration, photo-polymerization initiator concentration and a light source, the hydrogel is easy to form and has excellent mechanical properties and biocompatibility, and redox responsiveness of the hydrogel helps load different drug molecules and release them effectively.

The invention relates to the technical field of building materials, and discloses an energy-saving high-strength autoclaved sand-lime brick production and processing method. The autoclaved sand-lime brick comprises the following raw materials (by mass): 20%-30% of natural sand, 20%-30% of glass fragments, 20%-40% of quick lime, 20%-40% of fly ash, and 5%-15% of super absorbent resin particles. According to the energy-saving high-strength autoclaved sand-lime brick production and processing method, the raw materials are doped with the glass fragments to serve as the siliceous material, the glass fragments can be used for producing the autoclaved sand-lime brick, resources can be saved, pollution of the glass fragments to the environment can be reduced, and the purposes of energy conservation and high strength are achieved; meanwhile, the super absorbent resin is added into the raw materials, so that the curing time is shortened, and the production efficiency is improved.

The invention discloses a pig iron casting surface rust removal method based on a paste acidic rust remover. A liquid storage box is included, strip-shaped grooves in the bottom wall of the liquid storage box are clamped with strip-shaped grinding blocks, stainless steel thin pipes are arranged on the bottom wall of the liquid storage box, a feeding port is formed in the side wall of the liquid storage box, a piston plate is sleeved with the inner wall of the liquid storage box in a sealed manner, the piston plate is connected with telescopic rods, and the telescopic rods communicate with an air pump; and a grab handle and supporting legs are arranged on the top wall of the liquid storage box, and the grab handle is provided with a switch button and finger grooves. The invention further provides the pig iron casting surface rust removal method based on the paste acidic rust remover. The novel liquid storage box is designed, rust removal acid liquid, a hydroxyethyl cellulose aqueous solution and fine sand are sequentially poured into the liquid storage box, paste is generated through forced hydrolyzability of TiCl4 and tetraethoxysilane, the paste is extruded to the surface of a casting through the stainless steel thin pipes, the strip-shaped grinding blocks are used for rubbing, grinding and brushing, after multiple times of rubbing and grinding, slightly yellow white foam is formed, rust or burrs and burr defects which are difficult to treat can be cleaned up, and complex treatment such as cutting is not needed.

The invention relates to a 1,4-cyclohexane diformyl based preparation method of transparent hydrogel, belonging to the technical field of chemical materials. The preparation method comprises the following steps of: (1) preparing a solution containing low molecular weight organic molecules of the 1, 4-cyclohexane diformyl; (2) selecting physiological saline or a buffer solution, or body fluids of animals and plants or human bodies, or a tissue culture solution mixture; (3) placing a part of the solution of the organic molecules of the 1,4-cyclohexane diformyl prepared in the step (1) into a container, then adding nine parts of the physiological saline or the buffer solution, the body fluids of the animals and plants, the human bodies, the tissue culture solution mixture which is selected in the step (2) to the container, shaking to mix the solution by utilizing a burette or a hand, and finally stranding for 5-30 minutes so as to obtain the transparent hydrogel. The obtained transparent hydrogel has the advantages of easy preparation and operation, high productivity, easy post treatment and good biocompatibility, water-solubility, water absorbability and permeability.

The invention provides a hole sealing material for karst water inflow and further correspondingly provides a preparation method and hole sealing method thereof. The hole sealing material comprises, byweight, 70-90 parts of portland cement, 10-15 parts of coal ash, 10-20 parts of bentonite, 0.05-0.16 part of sodium carboxymethyl cellulose, 15-40 parts of water, 3-5 parts of water glass and 1-2 parts of hemp thread. The hole sealing material is sufficiently kneaded, can be quickly solidified, has the advantages of good water stability, dispersion resistance, durability, high strength and the like, helps to lower the cost, improve the construction quality and make water plugging construction more convenient, achieves the aim of efficient hole sealing, and is suitable for hole sealing operation in a high-pressure water-rich karst area. The preparation method and hole sealing method of the hole sealing material are easy to operate, less in equipment input and low in cost, cause no pollution to the environment, and can guarantee the hole sealing effect and improve the hole sealing efficiency.

A degradable temp-sensitive physically cross-linked hydrogel used as the slow-releasing carrier of injection is prepared from polyethylene glycol (PEG) as hydrophilic block, degradable polyester as hydrophobic block and the polymer terminated by functional radical through physical cross-linking.

The invention discloses a star-type polylactic acid-polyethylene glycol monomethyl ether copolymer. The preparation method of the star-type polylactic acid-polyethylene glycol monomethyl ether copolymer comprises the following steps of: initiating lactide to carry out ring opening polymerization to form star-type polylactic acid by using propanetriol or pentaerythritol as an initiator, adding organic base and a basic catalyst by using butanedioic anhydride as an acylating agent and dimethyl sulfoxide as a solvent and carrying out carboxylation on the tail end of the star-type polylactic acid; adding the star-type polylactic acid of which the tail end is subjected to carboxylation in an organic solvent; then adding the polyethylene glycol monomethyl ether, a condensing agent and a catalyst for reacting; and after the reacting, filtering, dissolving a product in water and gradually raising the temperature until precipitation is generated and obtaining the star-type polylactic acid-polyethylene glycol monomethyl ether copolymer. The hydrogel disclosed by the invention is in a solution state at normal temperature or at the temperature lower than normal temperature and can be quickly gelated at 37DEG C; the formed hydrogel can be degraded in the body and has favorable biocompatibility; and the invention has the advantages of simple synthetic method, mild reaction conditions and suitability for industrial production.

The invention relates to a hydrogel material and a preparation method thereof, and particularly relates to an injectable moulded silk fibroin hydrogel and a preparation method thereof. The method comprises the following steps: storing a silk fibroin water solution having a concentration of 10 to 300 g / l and a surfactant solution having a concentration of 0.01 to 100 g / l at a temperature of 2 to 8DEG C, evenly mixing the two solutions according to a volume ratio of 10:1, and standing the mixed solution at a temperature of 30 to 40 DEG C for 5 to 30 minutes; therefore, an injectable moulded silk fibroin hydrogel is obtained. The injectable moulded silk fibroin hydrogel has good biocompatibility and is applicable to biomedical fields such as artificial skin, artificial cartilage, cell culture support, bioreactors, enzyme immobilized materials and pharmaceutical accessories. Particularly, it is convenient for the silk fibroin hydrogel to form in vivo in situ, thereby avoiding wounds by surgery; therefore, the injectable moulded silk fibroin hydrogel is particularly applicable to the restoration of tissues of a complex shape.