1results about How to "Rapid gelation" patented technology

The present application relates to a kind of cartilage-like biomimetic double-sided hydrogel and its preparation method and application, belong to biomaterials technical field.The cartilage-like biomimetic double-sided hydrogel of the present application mainly includes ion salt bridge regulation self-assembly I type collagen, doped modified hyaluronic acid and metabolic regulator, wherein ion salt bridge regulation self-assembly I type collagen as main chain is crosslinked with doped modified hyaluronic acid by the combination mediated by covalent interaction, including Michael addition and Schiff base reaction and non-covalent hydrogen bond, the metabolic regulator is loaded in the hydrogel net cavity formed by self-assembly I type collagen and doped modified hyaluronic acid.The main chain of the hydrogel is I type collagen and doped modified hyaluronic acid chain with biocompatibility, biodegradability, gelation is rapid, efficient, and can be used for in situ gelation.By synergistic in situ mechanical metabolic regulation, become the new idea in the clinical management of osteoarthritis.