31results about How to "Rapid gelation" patented technology

The invention discloses the preparation and application of a near-infrared photopolymerizable injectable hydrogel, which is a methacryloyl carboxymethyl chitosan solution with double bonds introduced under near-infrared light, and the modified hydrogel prepared above Gold nanorods, 4ARM‑PEGSH, and VAZO44 solutions are added with the required amount of antineoplastic drugs. The hydrogel is obtained by near-infrared photopolymerization, and after being injected into the tumor site, a photothermal treatment can be completed. When near-infrared photopolymerized hydrogels are obtained in vivo, antitumor drugs can be chemotherapeutic through sustained release. In this way, the combined treatment of photothermal + chemotherapy can be completed to achieve the purpose of treating tumors.

The invention provides a method for rapid gelation of a silk protein solution under physiological conditions. The method comprises the following steps: (1) weighing NapFF solid powder to put onto thebottom of a glass vial, and adding ultrapure water; (2) adding a NaOH solution, performing ultrasonic auxiliary dissolution, and using a precise temperature control micro-computer electro-heating plate for heating the bottom of the vial at 70 DEG C for 1-2 min to form a transparent solution; (3) slowly adding a HCl solution, and stirring well with a pipette until solution pH is 7.2-7.5; (4) addingthe silk protein solution; (5) adding the ultrapure water to a metered volume of 200 mu L; and (6) placing horizontally, and observing the gelation process by tilting and inverting the glass vial. The method can induce the rapid gelation of the low-concentration silk protein solution in a short period of time, and the gelatinized silk protein solution can be degraded hydrolysis in the body by useof proteolytic enzyme, does not produce toxic and side effects, has good biocompatibility, and can be used as a good biomaterial.

The invention belongs to the technical field of functional materials, and relates to a multifunctional hydrogel triggered by lignin phenolic resin-loaded silver nanospheres, a preparation method and application thereof. The preparation method of the multifunctional hydrogel containing the lignin-phenolic resin-loaded silver nanospheres includes: (1) the preparation method of the lignin-phenolic resin-loaded silver nanospheres. Dissolving lignin, phenol, formaldehyde and sodium hydroxide in water, after hydrothermal curing, centrifuging and drying the obtained solution to obtain lignin phenolic resin nanospheres; adding the obtained lignin phenolic resin nanospheres to silver ammonia solution, stirring at room temperature Centrifugal drying to obtain lignin phenolic resin-loaded silver nanospheres. (2) The preparation method of the multifunctional hydrogel. The obtained lignin phenolic resin-loaded silver nanospheres and ferric trichloride hexahydrate are mixed and stirred uniformly in water, then an initiator and a crosslinking agent are added, and the multifunctional hydrogel can be obtained by standing at room temperature. The problem of complex transaction conditions and single function of hydrogel in the prior art is solved.

The invention relates to a method for preparing and using an injectable composite chitosan hydrogel for bone repair. The hydrogel is mainly composed of modified chitosan, inner cells and cell growth-promoting factors. Firstly, the hydrogel precursor solution is prepared by emulsion polymerization, the main component is chitosan macromolecules grafted with poly-N-isopropylacrylamide, the hydrogel can be in solution state at room temperature, and is stable in human physiology. Rapid gelation at ambient temperature. By mixing with cell suspension and cell growth-promoting factors, the resulting composite solution can realize in-situ rapid gelation at the site of bone tissue injury, and achieve in-situ fixation of cells, which can not only provide good support for the injury site, but also promote Adhesion, proliferation and differentiation of internal cells. Due to the simple preparation, convenient use, rapid response, and good biocompatibility, the hydrogel can be used in many biomedical related fields such as tissue repair, drug controlled release, cell culture, and cancer treatment.

The invention discloses a two-component superhydrophobic polyurethane ring adhesive activated by ultraviolet rays, which includes two components A and B, wherein component A is a hydrophobic polyurethane prepolymer; component B is composed of the following components as follows: Mixed by mass ratio: 85-97% macromolecular hydrophobic polyol, 1-10% organic fluorosilicon modified phosphate ester, 1-5% photobase generator, 0.001%-0.5% defoamer, each component And meet 100%; the ring glue mixed with A and B components has a very good adhesion to optical fiber and metal, and the operation time at room temperature is long, and the curing activity can be activated under the irradiation of ultraviolet light, and the rapid curing can be achieved in 5-30 minutes. Gel, realize the flexible operation of the ring glue.

A degradable temp-sensitive physically cross-linked hydrogel used as the slow-releasing carrier of injection is prepared from polyethylene glycol (PEG) as hydrophilic block, degradable polyester as hydrophobic block and the polymer terminated by functional radical through physical cross-linking.

The invention relates to a gel storehouse, its preparation method and the application of postoperative hemostatic preparations, belonging to the technical field of biomedicine. The gel storage includes 40-55 mass parts of phospholipids, 40-55 mass parts of glycerides and 5-20 mass parts of cosolvent; or the outer gel storage is wrapped outside the inner gel storage; The outer gel reservoir includes 28-38 mass parts of phospholipids, 62-70 mass parts of glycerides and 1-8 mass parts of cosolvent, and the inner gel reservoir includes 40-55 mass parts of phospholipids, 40-70 mass parts of glycerides 55 parts by mass and 5-20 parts by mass of cosolvent. Preferably, the gel depot also includes a drug. The invention uses two raw materials of phospholipid and glyceride, and through mixing, the gel precursor can be quickly gelled when it meets water, so as to quickly seal the bleeding point. The inner gel of the double-layer reservoir has the characteristics of rapid gelation and high strength, which can quickly seal the bleeding point, and the outer gel has strong adhesion, which ensures that the entire gel system is not easy to fall off.

The invention discloses a star-type polylactic acid-polyethylene glycol monomethyl ether copolymer. The preparation method of the star-type polylactic acid-polyethylene glycol monomethyl ether copolymer comprises the following steps of: initiating lactide to carry out ring opening polymerization to form star-type polylactic acid by using propanetriol or pentaerythritol as an initiator, adding organic base and a basic catalyst by using butanedioic anhydride as an acylating agent and dimethyl sulfoxide as a solvent and carrying out carboxylation on the tail end of the star-type polylactic acid; adding the star-type polylactic acid of which the tail end is subjected to carboxylation in an organic solvent; then adding the polyethylene glycol monomethyl ether, a condensing agent and a catalyst for reacting; and after the reacting, filtering, dissolving a product in water and gradually raising the temperature until precipitation is generated and obtaining the star-type polylactic acid-polyethylene glycol monomethyl ether copolymer. The hydrogel disclosed by the invention is in a solution state at normal temperature or at the temperature lower than normal temperature and can be quickly gelated at 37DEG C; the formed hydrogel can be degraded in the body and has favorable biocompatibility; and the invention has the advantages of simple synthetic method, mild reaction conditions and suitability for industrial production.