31results about How to "Rapid gelation" patented technology

The invention provides temperature-sensitive chitosan-carboxymethylcellulose gel and a preparation method and application thereof. The temperature-sensitive chitosan-carboxymethylcellulose gel is prepared by physically crosslinking the chitosan and sodium carboxymethylcellulose at the temperature of 10 DEG C or below. The gel system has rapid temperature-sensitive response performance and can be kept in a liquid state at room temperature or when the temperature is lower than room temperature, and gelatinization can be rapidly realized when the temperature reaches body temperature. The gel preparation method is simple and practicable in operation, the reaction conditions are mild, and organic chemical reagents or other harmful substances can be avoided. The prepared temperature-sensitive gel is suitable for industries such as medicine products, skin care products and foods.

The invention belongs to the field of polymer composite hydrogel, and relates to an injectable and rapidly-gelatinized composite hydrogel and a preparation method thereof, wherein the composite hydrogel is formed by crosslinking a water-soluble polymer with an amino group and a water-soluble polymer with an aldehyde group; the composite hydrogel has the pH response characteristics and injectability; the composite hydrogel forms a three-dimensional network structure through the interaction between the amino group and the aldehyde group, various drugs or growth factors and other bioactive molecules can be loaded in the three-dimensional network structure. In addition, the composite hydrogel has injectability, and because the carbon-nitrogen double bond Schiff base linking structure formed bythe amino group and the aldehyde group has pH response characteristics, the composite hydrogel can be used as a polymer hydrogel wound dressing having certain application prospects in the fields of drug releasing, skin wound repair and the like.

The invention discloses a star-type polylactic acid-polyethylene glycol monomethyl ether copolymer. The preparation method of the star-type polylactic acid-polyethylene glycol monomethyl ether copolymer comprises the following steps of: initiating lactide to carry out ring opening polymerization to form star-type polylactic acid by using propanetriol or pentaerythritol as an initiator, adding organic base and a basic catalyst by using butanedioic anhydride as an acylating agent and dimethyl sulfoxide as a solvent and carrying out carboxylation on the tail end of the star-type polylactic acid;adding the star-type polylactic acid of which the tail end is subjected to carboxylation in an organic solvent; then adding the polyethylene glycol monomethyl ether, a condensing agent and a catalystfor reacting; and after the reacting, filtering, dissolving a product in water and gradually raising the temperature until precipitation is generated and obtaining the star-type polylactic acid-polyethylene glycol monomethyl ether copolymer. The hydrogel disclosed by the invention is in a solution state at normal temperature or at the temperature lower than normal temperature and can be quickly gelated at 37DEG C; the formed hydrogel can be degraded in the body and has favorable biocompatibility; and the invention has the advantages of simple synthetic method, mild reaction conditions and suitability for industrial production.

The present invention relates to composition(s) comprising collagen, calcium ions and alginate, wherein the composition polymerizes in situ when contacted with blood. The composition may further comprise an erythrocyte aggregation agent and/or a platelet activation agent. The composition may be formulated into two separate formulations. The first formulation comprises collagen in a calcium-containing solution and a second formulation comprises an aqueous alginate solution. The two formulations can be mixed prior to the contact with blood or mixed coincident with the contact with blood.

The invention provides a nanogel hemostatic material modified with modified glucan as well as preparation and an application of the nanogel hemostatic material. The nanogel hemostatic material is formed by polymerizing modified glucose and monomers containing vinyl, wherein the modified glucose is glucose modified with glycidyl methacrylate. The nanogel hemostatic material has excellent water absorption and good biocompatibility, the size is increased after the nanogel hemostatic material absorbs water to expand, a polymer hydrogel layer is formed and can block a wound to stop bleeding, modified glucan nonogel has an excellent hemostatic effect on traumatic hemorrhage such as venous hemorrhage, arterial hemorrhage, body surface hemorrhage as well as internal organ hemorrhage such as liver hemorrhage, is a good and novel hemostatic and has good application prospects in clinical trauma. The invention further provides a preparation method of the modified polysaccharide modified nanogel hemostatic material. The raw materials are cheap and easy to obtain, the reaction condition is mild, the reaction operation is simple, and post-treatment is convenient.

The invention discloses hydrogel with multiple response function and a preparation method and application thereof; the preparation method of the hydrogel comprises the steps of adding hydrogel material, acryloyl chloride and triethylamine into a solvent, and reacting under ice bath to obtain modified hydrogel material; adding diselenide-diol, acryloyl chloride and triethylamine into a solvent, reacting under ice bath to obtain modified diselenide with C-C double bond; mixing the modified hydrogel material solution with the modified diselenide solution, adding a photo-polymerization initiator, and irradiating in ultraviolet at 20-40 DEG C to generate hydrogel having multiple response function. The hydrogel material is responsive to temperature, light and redox, quick gelling can be achieved by adjusting temperature, bulk concentration, photo-polymerization initiator concentration and a light source, the hydrogel is easy to form and has excellent mechanical properties and biocompatibility, and redox responsiveness of the hydrogel helps load different drug molecules and release them effectively.

The invention discloses a nano hybrid silk fibroin hydrogel and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The nano hybrid silk fibroin hydrogel is prepared by pre-blending a regenerated silk fibroin aqueous solution and nano hydroxyapatite and performing ultrasonic treatment. According to the preparation method of the nano hybrid silkfibroin hydrogel, the ultrasonic condition and the mixing ratio of the two materials are changed, the gelation time is controlled, and rapid gelation is realized, so that use of a potentially toxic chemical crosslinking agent is avoided, and activity of cells or biological factors can be well maintained. The nano hybrid silk fibroin hydrogel provided by the invention has controllable gel performance, controllable mechanical performance, good cell compatibility and good bone induction capability, can load stem cells for repairing bone defect, and is expected to be used for embedding active factors for synergistic treatment.

The invention belongs to the technical field of functional materials, and relates to multi-functional hydrogel triggered by lignin phenolic resin silver-loaded nano spheres as well as a preparation method and application thereof. The preparation method of the multi-functional hydrogel containing the lignin phenolic resin silver-loaded nano spheres comprises the following steps: (1) preparing the lignin phenolic resin silver-loaded nano spheres: dissolving lignin, phenol, formaldehyde and sodium hydroxide in water, carrying out hydrothermal curing, and carrying out centrifugal drying on the obtained solution to obtain lignin phenolic resin nano spheres; and adding the obtained lignin phenolic resin nano spheres into a silver-ammonia solution, stirring at the room temperature, and carrying out centrifugal drying to obtain the lignin phenolic resin silver-loaded nano spheres. and (2) preparing the multi-functional hydrogel: uniformly mixing and stirring the obtained lignin phenolic resin silver-loaded nano spheres and ferric trichloride hexahydrate in water, then adding an initiator and a cross-linking agent, and standing at the room temperature to obtain the multi-functional hydrogel. The problems of complex hydrogel forming conditions and single function in the prior art are solved.

The invention provides a hole sealing material for karst water inflow and further correspondingly provides a preparation method and hole sealing method thereof. The hole sealing material comprises, byweight, 70-90 parts of portland cement, 10-15 parts of coal ash, 10-20 parts of bentonite, 0.05-0.16 part of sodium carboxymethyl cellulose, 15-40 parts of water, 3-5 parts of water glass and 1-2 parts of hemp thread. The hole sealing material is sufficiently kneaded, can be quickly solidified, has the advantages of good water stability, dispersion resistance, durability, high strength and the like, helps to lower the cost, improve the construction quality and make water plugging construction more convenient, achieves the aim of efficient hole sealing, and is suitable for hole sealing operation in a high-pressure water-rich karst area. The preparation method and hole sealing method of the hole sealing material are easy to operate, less in equipment input and low in cost, cause no pollution to the environment, and can guarantee the hole sealing effect and improve the hole sealing efficiency.

The invention discloses a starch-based hemostatic material with a time series hemostatic effect and a preparation method thereof. The starch-based hemostatic material is a hydrogel dosage form formedby a modified starch solution under the catalysis of hydrogen peroxide and catalase. The preparation reaction is carried out under homogeneous conditions, and the problems of high reaction conditionsand low degree of substitution in previous heterogeneous reactions are solved. The preparation process is simple and a preparation cycle is short. The prepared starch-based hemostatic gel can rapidlygelate in case of wound and effectively block the wound, then adheres to activate blood cells and coagulation factors, and then activates a coagulation system, so as to achieve the rapid time series hemostatic effect and promote the wound healing effect. The starch-based hemostatic material is a hemostatic material with broad application prospects.

The invention discloses a medical eye patch used for infants and children. The medical eye patch comprises an anti-sticking layer (1), a micro-needle array layer (2), an eye medicine storage layer (3)and a sticking layer (4). The invention also discloses a preparation method and a purpose of the medical eye patch. The medical eye patch is simple in use and preparation, and does not hurt the eyesof infants and children.

The invention relates to the technical field of building materials, and discloses an energy-saving high-strength autoclaved sand-lime brick production and processing method. The autoclaved sand-lime brick comprises the following raw materials (by mass): 20%-30% of natural sand, 20%-30% of glass fragments, 20%-40% of quick lime, 20%-40% of fly ash, and 5%-15% of super absorbent resin particles. According to the energy-saving high-strength autoclaved sand-lime brick production and processing method, the raw materials are doped with the glass fragments to serve as the siliceous material, the glass fragments can be used for producing the autoclaved sand-lime brick, resources can be saved, pollution of the glass fragments to the environment can be reduced, and the purposes of energy conservation and high strength are achieved; meanwhile, the super absorbent resin is added into the raw materials, so that the curing time is shortened, and the production efficiency is improved.

The invention discloses a pig iron casting surface rust removal method based on a paste acidic rust remover. A liquid storage box is included, strip-shaped grooves in the bottom wall of the liquid storage box are clamped with strip-shaped grinding blocks, stainless steel thin pipes are arranged on the bottom wall of the liquid storage box, a feeding port is formed in the side wall of the liquid storage box, a piston plate is sleeved with the inner wall of the liquid storage box in a sealed manner, the piston plate is connected with telescopic rods, and the telescopic rods communicate with an air pump; and a grab handle and supporting legs are arranged on the top wall of the liquid storage box, and the grab handle is provided with a switch button and finger grooves. The invention further provides the pig iron casting surface rust removal method based on the paste acidic rust remover. The novel liquid storage box is designed, rust removal acid liquid, a hydroxyethyl cellulose aqueous solution and fine sand are sequentially poured into the liquid storage box, paste is generated through forced hydrolyzability of TiCl4 and tetraethoxysilane, the paste is extruded to the surface of a casting through the stainless steel thin pipes, the strip-shaped grinding blocks are used for rubbing, grinding and brushing, after multiple times of rubbing and grinding, slightly yellow white foam is formed, rust or burrs and burr defects which are difficult to treat can be cleaned up, and complex treatment such as cutting is not needed.