High-strength and high-corrosion-resistance biomedical Mg-Ga alloy and preparation method thereof

A high corrosion resistance, biomedical technology, applied in the field of medical alloys, can solve the problem that the mechanical properties of materials have not been significantly improved, and achieve the effect of expanding the scope of clinical application, high strength and high corrosion resistance.

Active Publication Date: 2019-07-16
烟台浩忆生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the low content of Ga added, the mechanical properties of the material have not been significantly improved. In addition, Cu is an element that has been confirmed to be hepatotoxic, and the content of Cu as an implant material should be strictly controlled.

Method used

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  • High-strength and high-corrosion-resistance biomedical Mg-Ga alloy and preparation method thereof
  • High-strength and high-corrosion-resistance biomedical Mg-Ga alloy and preparation method thereof
  • High-strength and high-corrosion-resistance biomedical Mg-Ga alloy and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0032] In this embodiment, the composition and weight percentage of the binary Mg-Ga alloy material are: Ga 5.0%, and the rest is Mg. The alloy contains a small amount of Mn, Si, Fe, Ni impurity elements.

[0033] The preparation method of magnesium alloy is specifically as follows:

[0034] (1) Take the raw materials pure magnesium, pure gallium and pure zinc according to the stated ratio, and the purity is not higher than 99.99wt%; (2) Cut a certain amount of pure magnesium with a thickness of 0.5-1mm and a diameter of 50-100mm from the raw materials The gallium is placed in the center of the magnesium sheet, and the gallium is wrapped into the magnesium by mechanical means;

[0035] (3) Put pure magnesium and pure magnesium wrapped with gallium in a high-strength graphite crucible, heat it in a resistance furnace, heat it up to 750-770°C and keep it warm for 3 hours, and use an ultrasonic stirrer every 15 minutes to heat the melt Perform ultrasonic stirring, stirring 8-10...

Embodiment 2

[0045] In this embodiment, the composition and weight percentage of the Mg-Ga alloy material are: Ga 7.0%, and the rest is Mg. The alloy contains a small amount of Mn, Si, Fe, Ni impurity elements.

[0046] The difference between the preparation method and Example 1 is:

[0047] The solution temperature of magnesium alloy is 430°C, the solution time is 15 hours, and then aging treatment is performed, and the aging time is 25 hours at 200°C

[0048] After testing, the material has good biocompatibility, the cytotoxicity rating is 0, and the average grain size is 13 μm ( image 3 ), the degradation rate of the alloy was measured to be 0.3mm / y by weight loss test. The alloy can be degraded and absorbed in biological fluid or blood environment, and its tensile strength is 305MPa, yield strength is 98MPa, and elongation at break is 19%.

[0049] Processed from the above extruded alloys figure 2 For the screws shown, the tested screws can withstand a maximum torque of 2.73N.m. ...

Embodiment 3

[0051] In this embodiment, the composition and weight percentage of the Mg-Zn-Ga alloy material are: Ga 5.0%, Zn 1.0%, and the rest is Mg. The alloy contains a small amount of Mn, Si, Fe, Ni impurity elements.

[0052] (1) Weigh raw material pure magnesium and pure gallium according to the ratio, and the purity is not higher than 99.99wt%;

[0053] (2) Cut a certain amount of pure magnesium sheets with a thickness of 0.5-1mm and a diameter of 50-100mm from the raw material, place gallium at the center of the magnesium sheet, and mechanically wrap the gallium into the magnesium;

[0054] (3) Put pure magnesium and pure magnesium wrapped with gallium in a high-strength graphite crucible, put it into a resistance furnace and heat it to 700-720°C, after the raw materials are melted, add Zn, keep it warm for 1 hour, and then heat up to 750-770°C , keep warm for another 3 hours, and use an ultrasonic stirrer to ultrasonically stir the melt every 15 minutes at the beginning of the h...

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Abstract

The invention aims to provide a high-strength and high-corrosion-resistance biomedical Mg-Ga alloy and a preparation method thereof. The alloy comprises the following chemical components of, by weight, 4.5%-10.0% of Ga and the balance Mg element and other inevitable impurities. By adding a proper amount of the Ga element is added into a pure magnesium matrix, alloy grains can be refined, and the mechanical strength and the corrosion resistance of the alloy are improved. In addition, a Zn element can be added, the Mg-Zn-Ga phase can be separated from the alloy by adjusting a heat treatment system, so that the alloy is further strengthened. The alloy is excellent in biocompatibility, has the biological functions of promoting bones and the like, and is a multifunctional biomedical degradablemagnesium alloy material with excellent comprehensive performance, and has an important application value in the medical fields such as orthopedic implants.

Description

technical field [0001] The invention relates to the field of medical alloys, and specifically provides a high-strength and high-corrosion-resistant biomedical Mg-Ga alloy and a preparation method thereof. Background technique [0002] Biodegradable medical magnesium alloys have mechanical properties close to bone and good biocompatibility, and have been widely used as temporary implant devices such as fracture fixators and bone filling materials abroad. The degradable characteristics of medical magnesium alloy can avoid the medical risks caused by secondary surgery. Internationally, at present, one company in Germany and South Korea has obtained the certification of degradable magnesium alloy bone nail products, and another US company has obtained the certification of magnesium-based resorbable bone filling material products. There is no biodegradable medical magnesium alloy medical device product on the market in China. At present, only one company's magnesium alloy implan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/00C22C1/02C22F1/06C22F1/02
CPCC22C1/02C22C23/00C22F1/02C22F1/06
Inventor 李岩何东磊
Owner 烟台浩忆生物科技有限公司
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