Composition for regulating enteric microorganisms and preparation method thereof

A technology for regulating intestinal tract and composition, which is applied in the field of medicine, can solve problems such as intestinal microbial flora, unfavorable long-term maintenance, and increase probiotics, etc., to achieve the effect of strengthening killing and cleaning, reducing harmful bacteria, and increasing probiotics

Inactive Publication Date: 2017-08-11
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the existing technical methods can adjust the environment of human microorganisms, the effect of increasing the number of probiotics and reducing the number of harmful bacteria is not obvious, which is not conducive to long-term maintenance, and the maintenance of human intestinal microorganisms will rely on traditional Chinese medicine ingredients, so Not a great way to improve your gut microbiome

Method used

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  • Composition for regulating enteric microorganisms and preparation method thereof
  • Composition for regulating enteric microorganisms and preparation method thereof
  • Composition for regulating enteric microorganisms and preparation method thereof

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preparation example Construction

[0067] The present invention also provides a method for preparing a composition for regulating intestinal microorganisms, comprising the following steps:

[0068] It is obtained by mixing stem cell growth factor, human interferon-λ, human interleukin 2, Artemisia argyi leaf extract, human plasma albumin solution and a solvent.

[0069] The present invention does not limit the source of stem cell growth factor, which can be commercially available, preferably prepared according to the following method:

[0070] The culture supernatant of P3 generation umbilical cord mesenchymal stem cells was collected and concentrated.

[0071] The present invention is not limited to the cultivation and concentration, as long as those skilled in the art are familiar with it.

[0072] The present invention does not limit the source of human interferon-λ, which can be commercially available, preferably prepared according to the following method:

[0073] The culture supernatant of T lymphocytes...

Embodiment 1

[0092] The culture supernatant of P3 generation umbilical cord mesenchymal stem cells is collected and concentrated to obtain stem cell growth factors; the culture supernatant of T lymphocytes is collected and concentrated to obtain cytokines of immune cells. Interferon-λ, Interleukin 2, and Interleukin 11 were purified from immune cytokines; buy Artemisia argyi extract.

[0093] According to the dosage of each component, specifically: stem cell growth factor 50ng / mL, human interferon-λ 500U / mL, human interleukin 2 500U / mL, human interleukin 11 50U / mL, mugwort leaf extract 1μg / mL, 1vol% human plasma albumin solution. Dissolve and dilute the above components in physiological saline under aseptic conditions, so that the final composition volume is 100mL to obtain a composition for regulating intestinal microbes, which is placed in an ampoule bottle, 5mL / bottle.

[0094] The composition described in the present invention is intravenously infused, and the feces of people who have...

Embodiment 2

[0096] The culture supernatant of P3 generation umbilical cord mesenchymal stem cells is collected and concentrated to obtain stem cell growth factors; the culture supernatant of T lymphocytes is collected and concentrated to obtain cytokines of immune cells. Interferon-λ, Interleukin 2, and Interleukin 11 were purified from immune cytokines; buy Artemisia argyi extract.

[0097] According to the dosage of each component, specifically: stem cell growth factor 100ng / mL, human interferon-λ 1000U / mL, human interleukin 2 1000U / mL, human interleukin 11 100U / mL, mugwort leaf extract 2μg / mL, 1vol% human plasma albumin solution. Dissolve and dilute the above components in physiological saline under aseptic conditions, so that the final composition volume is 100mL to obtain a composition for regulating intestinal microbes, which is placed in an ampoule bottle, 5mL / bottle.

[0098] The composition described in the present invention is intravenously infused, and the feces of people who ha...

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Abstract

The invention provides a composition for regulating enteric microorganisms. The composition comprises solvent and components, such as, by weight, 50-500ng / mL of stem cell growth factor, 500-5000 U / mL of human interferon-Lambda, 500-5000 U / mL of human interleukin 2, 50-1000 U / mL of human interleukin 11, 1-10 mu g / mL of folium artemisiae argyi extractive, and 1vol%-3vol% of human plasma albumin solution. Through synergistic effect of the stem cell growth factor, the human interferon-Lambda, the human interleukin 2, the human interleukin 11, the human plasma albumin solution and the folium artemisiae argyi extractive, the composition can improve the whole immune system of a human body and strengthen the killing and removing ability of own immune cell to harmful flora; meanwhile, the composition can effectively regulate the intestinal microflora, increase probiotics, reduce harmful bacteria, and maintain a healthy environment of the whole intestinal canal.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition for regulating intestinal microbes and a preparation method thereof. Background technique [0002] There are a large number of symbiotic microorganisms in the human body, most of which live in the human intestinal tract, the number exceeds 1000 trillion (1014 orders of magnitude), which is more than 10 times the total number of human cells, and their total weight exceeds 1.5 kg. Circle the earth twice. The gastrointestinal tract is a "big warehouse" of microorganisms, and the human body is a gathering place for moving microorganisms. From a genomic perspective, the total genome of a healthy adult gut microbiome is unusually large. During the long evolutionary process, intestinal microbes have reached a good cooperation with human beings, and play a vital role in the nutrition, metabolism and immunity of the human body. Many researchers regard the human intestinal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/38A61P1/00A61P37/04A61P31/04A23L33/10A23L33/105A23L33/17A61K38/21A61K38/20A61K38/18A61K36/282A61K36/899
CPCA61K38/385A23V2002/00A61K9/0019A61K36/282A61K36/48A61K36/73A61K36/77A61K36/87A61K36/899A61K38/18A61K38/2013A61K38/2073A61K38/21A61K2300/00A23V2200/32A23V2250/21A23V2250/204A23V2250/5436A23V2250/21166
Inventor 葛啸虎陈海佳王一飞罗二梅王小燕
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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