6 results about "STEM CELL GROWTH FACTOR" patented technology

The invention discloses a cell composition for promoting hair regeneration and application thereof, and belongs to the field of biological medicine, the active component of the cell composition comprises a mixture of hair papilla cells, keratinocytes and stem cell growth factors; wherein the number ratio of the hair papilla cells to the keratinocytes is (1-3): (1-3), and the stem cell growth factor mixture comprises bFGF, KGF, HGF, VEGF, TGF-beta1 and PDGF. The cell preparation disclosed by the invention can be used for improving the hair growth effectiveness and solving different types of alopecia symptoms except for androgen alopecia, has a remarkable treatment effect on androgen alopecia, and has a remarkable effect on treating various alopecia symptoms. The traditional Chinese medicine composition has treatment effects on alopecia areata, alopecia in a resting period, alopecia in a growing period, scar alopecia and androgen-derived alopecia.

The invention discloses a thalassemia treatment method based on a stem cell technology and application. The thalassemia treatment method comprises the following steps: collecting a peripheral blood sample of a patient, and carrying out stem cell isolated culture; constructing a nucleic acid aptamer by combining a vascular cell adhesion molecule-1 and a stromal cell-derived factor-1 in a bone marrow microenvironment; connecting a nucleic acid aptamer, a cell adhesion promoting peptide and a stem cell growth factor, and constructing a homing guiding reagent; preparing nano liposome and nano polymer particles; the nucleic acid aptamer is connected to the surfaces of the nano-liposome and the nano-polymer particles, and is grafted with a temperature-responsive material to obtain the nano-carrier with a responsive release function; stem cell growth factors and platelet-derived growth factors are mixed with gelatin microspheres to form a slow release system; the cultured stem cells are mixed with a homing guide reagent, a nano-carrier and a slow release system, and are transplanted into the body of a patient through intramedullary injection. The stem cell homing efficiency can be improved, and the treatment effect on thalassemia is improved.

The present invention relates to antigen binding proteins that specifically bind to SCGF and comprises their use in the treatment of cancer inflammation and trauma. Also the present invention relates to nucleic acids encoding the antigen binding proteins, vectors comprising said nucleic acids and host cells comprising said expression vectors. Further, the invention relates to pharmaceutical compositions comprising said antigen binding protein and kits comprising said pharmaceutical compositions.

To provide a pharmaceutical composition for use in a method for modulating an inflammatory stress response within a hematopoietic bone marrow microenvironment comprising bone marrow endothelial cells (BMECs), hematopoietic stem cells (HSCs), and bone marrow stromal cells following a myelosuppressive insult.SOLUTION: Wherein the pharmaceutical composition comprises pharmacological means for modulating the inflammatory stress response comprising administration of recombinant or synthetic Clec11 alpha stem cell factor (SCGF) and / or genetic means comprising suppression of endothelial NF - κ B signaling; The pharmaceutical composition protects the bone marrow (BM) hematopoietic compartment by inhibiting NF - κ B in endothelial cells, suppressing downstream NF - κ B signaling in the BM, down-regulating target NF - κ B genes in the BM, or both, and promotes recovery after myelosuppressive injury and resolves inflammation.SELECTED DRAWING: None

The application discloses a hair restorer containing stem cell extract and a use method thereof. 100 mL of the hair restorer comprises the following raw materials: stem cell extract freeze-dried powder 50-250 mg, beta nicotinamide mononucleotide 100-650 mg, coenzyme Q10 10-120 mg, melatonin 10-220 mg, ginsenoside A2 10-240 mg, chuanxiong extract 0.2-2 g, safflower extract 0.2-2 g, dendrobium extract 0.3-3 g, radix falcaliae extract 1-8 g, ligustrum lucidum extract 1-8 g, and the rest is deionized water. The hair restorer contains stem cell growth factors, NMN metabolic energy substances, and is supplemented with coenzyme Q10, melatonin, ginsenoside A2, chuanxiong extract, safflower extract, dendrobium extract, radix falcaliae extract and ligustrum lucidum extract, and can promote hair follicle cell growth and hair growth.

A medium comprising a nucleic acid fragment mixture, and a stem cell culture technique based on same for high-efficiency production of stem cell-derived extracellular vesicles and proteins, of the present invention, can significantly increase the expression level of proteins such as growth factors and the production of extracellular vesicles of stem cells. Stem cells cultured by the method or extracellular vesicles obtained therefrom have a high protein amount, and thus can be effectively used in the cosmetic field for applications such as skin whitening, skin wrinkle reduction, hair color change, hair loss alleviation or prevention, acne alleviation, ultraviolet protection, skin inflammation alleviation, cell regeneration, antioxidant activity, anti-aging, skin moisturizing, skin condition improvement, skin soothing and stress relief, or skin texture refining and elasticity enhancement, and in the medical field for applications such as hair loss, inflammatory diseases, acne and folliculitis management, and scar prevention.