Mediterranean anemia treatment method based on stem cell technology and application

By constructing a nanocarrier and sustained-release system targeting the bone marrow microenvironment, the problem of low stem cell homing efficiency was solved, achieving efficient colonization and functional recovery of stem cells in the treatment of thalassemia.

CN121102498APending Publication Date: 2025-12-12ZHEJIANG UNIV
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Patent Information

Application Number
CN202511271563.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-08
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

Traditional treatments for thalassemia often result in low stem cell homing efficiency and limited functionality of nanocarriers, which fail to create a suitable environment for stem cell survival, thus limiting the success rate of stem cell transplantation.

Method used

By constructing a composite nanocarrier with both targeting and intelligent release functions, combining vascular cell adhesion molecule-1 and stromal cell-derived factor-1 in the bone marrow microenvironment, and using a dual-factor combination of SCF and PDGF loaded on gelatin microspheres, a sustained-release system is constructed to accurately identify and create a suitable survival environment.

Benefits of technology

It significantly improves the homing efficiency and colonization success rate of stem cells, restores the patient's hematopoietic function, reduces side effects, and improves treatment efficacy.

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Abstract

The invention discloses a thalassemia treatment method based on a stem cell technology and application. The thalassemia treatment method comprises the following steps: collecting a peripheral blood sample of a patient, and carrying out stem cell isolated culture; constructing a nucleic acid aptamer by combining a vascular cell adhesion molecule-1 and a stromal cell-derived factor-1 in a bone marrow microenvironment; connecting a nucleic acid aptamer, a cell adhesion promoting peptide and a stem cell growth factor, and constructing a homing guiding reagent; preparing nano liposome and nano polymer particles; the nucleic acid aptamer is connected to the surfaces of the nano-liposome and the nano-polymer particles, and is grafted with a temperature-responsive material to obtain the nano-carrier with a responsive release function; stem cell growth factors and platelet-derived growth factors are mixed with gelatin microspheres to form a slow release system; the cultured stem cells are mixed with a homing guide reagent, a nano-carrier and a slow release system, and are transplanted into the body of a patient through intramedullary injection. The stem cell homing efficiency can be improved, and the treatment effect on thalassemia is improved.
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