The invention relates to the technical field of
medical instruments, in particular to a
heparin coating based on material surface ammonification modification and a preparation method thereof, and the preparation method at least comprises the following steps: carrying out ultrasonic pretreatment on a base material with
purified water, and
drying for later use; the preparation method comprises the following steps: performing
amination modification on a base material subjected to ultrasonic pretreatment by adopting an ammoniation
reagent solution, and immersing the base material into a
heparin solution to prepare the base material with a
heparin coating on the surface. The surface of the material is subjected to
amination modification by adopting a micromolecular ammoniation
reagent and / or a macromolecular ammoniation
reagent system, complex pretreatment such as
plasma and
ultraviolet rays does not need to be carried out on a base material, specific functional group activation does not need to be carried out on heparin, and the heparin is directly reacted after being subjected to ammoniation modification; the stable covalent grafted heparin anticoagulation
coating can be formed, the anticoagulation time is prolonged, and the long-term implantation requirement is met.