Degradable biological composite material of phosphate containing calcium and preparation method thereof

A composite material and bioactive technology, applied in the field of biodegradable bioactive medical composite materials and their preparation, to achieve the effects of controllable degradation rate, easy control, and guaranteed biocompatibility

Inactive Publication Date: 2009-04-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned polymer/inorganic salt composite materials currently used cannot meet this requirement. Therefore, it is necessary to study bi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0020] Example 1

[0021] 70.845g Ca(NO 3 ) 2 ·4H 2 O was dissolved in 300ml of deionized water, and after it was completely dissolved, it was filtered through a glass sand funnel and put into a 100ml open beaker; 76.04g of Na 3 PO 4 ·12H 2 O was dissolved in 200ml of deionized water. After it was completely dissolved, it was filtered with a No. 4 glass sand funnel and placed in a separatory funnel. Under the condition of stirring at room temperature and adjusting with sodium bicarbonate and keeping the pH at 6.9~7.1, add the sodium phosphate solution to the calcium nitrate solution dropwise, and finish adding in 20 minutes. Heat to 80℃ for 2 hours, cool and seal naturally, after standing for 48 hours, remove the clear liquid, wash with deionized water 6 times to obtain nano-scale calcium phosphate slurry, the content is 3.75wt%, the molar ratio of Ca / P is 1.51 ,spare.

[0022] Add 1000g of the above calcium phosphate slurry and 45.2g of caprolactam, 0.75g of glycine, 1.31g of leu...

Example Embodiment

[0023] Example 2

[0024] The preparation of nano calcium phosphate slurry is the same as that in Example 1.

[0025] The three-necked flask was charged with 1000 g of nano calcium phosphate slurry prepared in the same manner as in Example 1, and 45.2 g of caprolactam, 0.75 g of glycine, 1.31 g of leucine, 2.475 g of phenylalanine, 1.46 g of lysine, and proline It is 2.875g, serine is 1.051g, alanine is 1.782g, stirring is heated to 70°C under the protection of nitrogen, caprolactam is melted, and stirring is continued to be heated to 200°C and kept at constant temperature for 1 hour. The temperature was raised to 220° C. for pre-polymerization reaction for 0.5 hour, then the temperature was raised to 230° C. for polymerization reaction for 1 hour, and it was cooled to room temperature to obtain 88.5 g of light yellow composite product. The test results of the obtained composite product: the calcium phosphate content in the composite material is 40%; the compressive strength is 10...

Example Embodiment

[0026] Example 3

[0027] The preparation of nano calcium phosphate slurry is the same as that in Example 1.

[0028] The three-necked flask was charged with 1000 g of nano calcium phosphate slurry prepared in the same manner as in Example 1, and 45.2 g of caprolactam, 0.75 g of glycine, 1.31 g of leucine, 2.475 g of phenylalanine, 1.46 g of lysine, and proline It is 2.875g, serine is 1.051g, alanine is 1.782g, stirring is heated to 70°C under the protection of nitrogen, caprolactam is melted, and stirring is continued to be heated to 200°C and kept at constant temperature for 1 hour. The temperature was raised to 220°C for pre-polymerization reaction for 5 hours, then the temperature was raised to 230°C for polymerization reaction for 4.5 hours, and it was cooled to room temperature to obtain 85 g of a light yellow composite product. The test results of the obtained composite product: the calcium phosphate content in the composite material is 40%; the compressive strength is 143M...

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Abstract

The invention provides a degradable bioactivity composite containing calcium phosphate and a preparation method thereof. The composite consists of calcium phosphate and a multiple amino acid polymer; wherein, the weight percentage of inorganic composition is not more than 50 percent and the residual substance is the multiple amino acid polymer which is formed by the polymerization of caprolactam and at least 5 other amino acids; wherein, the molar ratio of the caprolactam in the polymer is 40-90 percent and the respective molar ratio of other single amino acid is not less than 0.5 percent. During preparation, the caprolactam is mixed with all amino acids and dehydration is carried out under the protection of inert gases and stirring, and pre-polymerization composition reaction and polymerization reaction are respectively carried out at the temperature of 210-250DEG C, thus obtaining the composite. The indexes of the prepared material such as mechanic performance, degradation period and the like can be adjusted and controlled according to the use requirements.

Description

technical field [0001] The invention relates to a degradable bioactive medical composite material containing calcium phosphate and a preparation method thereof. Background technique [0002] Currently, bioactive medical composite materials containing calcium-containing phosphate inorganic components have been reported and / or used, including degradable and non-degradable materials. Degradable components such as Ca(H 2 PO 4 ) 2 (MCP), Ca 2 P 2 o 7 (CPP), CaHPO 4 2H 2 O(DCP), Ca 3 (PO 4 ) 2 (TCP), etc.; non-degradable components may include such as Ca 10 (PO 4 ) 6 (HO) 2 (HA), Ca 10 (PO 4 ) 6 O(OXA) and CaO·Ca 3 (PO 4 ) 2 (TTCP) etc. Due to its good bioactivity and biocompatibility, it has been widely used in the field of bone repair and bone reconstruction. In particular, tricalcium phosphate (TCP), which has a calcium / phosphorus ratio of 1.5 and is degradable, has excellent biological properties and can guide tissue growth, that is, it has osteoconductiv...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/12A61L27/58
Inventor 严永刚李鸿南景天罗小满黄志鹃何丽萍杨杰张其翼吕国玉杨爱萍
Owner SICHUAN UNIV
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