Degradable biological composite material of phosphate containing calcium and preparation method thereof
A composite material and bioactive technology, applied in the field of degradable bioactive medical composite materials and their preparation, to achieve the effects of controllable degradation rate, guaranteed biocompatibility and low cost
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Embodiment 1
[0021] 70.845g Ca(NO 3 ) 2 4H 2 O was dissolved in 300ml deionized water, after it was completely dissolved, it was filtered through a No. 4 glass sand funnel and put into a 100ml open beaker; 76.04g Na 3 PO 4 12H 2 O was dissolved in 200ml deionized water, and after it was completely dissolved, it was filtered with a No. 4 glass sand funnel and put into a separatory funnel. Stir at room temperature and adjust with sodium bicarbonate to maintain pH 6.9-7.1, add the sodium phosphate solution dropwise to the calcium nitrate solution, and complete the addition in 20 minutes. Heating to 80°C for 2 hours, cooling and sealing naturally, after standing for 48 hours, removing the supernatant, and washing with deionized water 6 times to obtain nano-scale calcium phosphate slurry with a content of 3.75wt% and a Ca / P molar ratio of 1.51 ,spare.
[0022] Add the above-mentioned calcium phosphate slurry 1000g and caprolactam 45.2g, glycine 0.75g, leucine 1.31g, phenylalanine 2.475g, ...
Embodiment 2
[0024] The preparation of nano calcium phosphate slurry is the same as in Example 1.
[0025] Add nano-calcium phosphate slurry 1000g and caprolactam 45.2g prepared in the same manner as in Example 1 in the three-necked bottle, glycine 0.75g, leucine 1.31g, phenylalanine 2.475g, lysine 1.46g, proline was 2.875g, serine was 1.051g, and alanine was 1.782g. Stir and heat up to 70°C under nitrogen protection, caprolactam melted, continue stirring and heat up to 200°C and keep the temperature for 1 hour. The temperature was raised to 220°C for 0.5 hours of pre-polymerization, then the temperature was raised to 230°C for 1 hour of polymerization, and then cooled to room temperature to obtain 88.5 g of a light yellow complex product. Test results of the composite product obtained: the calcium phosphate content in the composite material is 40%; the compressive strength is 102Mpa, the tensile strength is 95Mpa, the bending strength is 74Mpa, and the modulus of elasticity is 2.5Gpa; aft...
Embodiment 3
[0027] The preparation of nano calcium phosphate slurry is the same as in Example 1.
[0028] Add nano-calcium phosphate slurry 1000g and caprolactam 45.2g prepared in the same manner as in Example 1 in the three-necked bottle, glycine 0.75g, leucine 1.31g, phenylalanine 2.475g, lysine 1.46g, proline was 2.875g, serine was 1.051g, and alanine was 1.782g. Stir and heat up to 70°C under nitrogen protection, caprolactam melted, continue stirring and heat up to 200°C and keep the temperature for 1 hour. The temperature was raised to 220°C for 5 hours of pre-polymerization, then the temperature was raised to 230°C for 4.5 hours of polymerization, and then cooled to room temperature to obtain 85 g of a light yellow complex product. Test results of the composite product obtained: the calcium phosphate content in the composite material is 40%; the compressive strength is 143Mpa, the tensile strength is 131Mpa, the bending strength is 115Mpa, and the modulus of elasticity is 8.5Gpa; af...
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