Degradable biological composite material of phosphate containing calcium and preparation method thereof

A composite material and bioactive technology, applied in the field of degradable bioactive medical composite materials and their preparation, to achieve the effects of controllable degradation rate, guaranteed biocompatibility and low cost

Inactive Publication Date: 2012-11-21
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned polymer / inorganic salt composite materials currently used cannot meet this requirement. Therefore, it is necessary to study bioactive biomimetic biomaterials that can adapt to the in vivo environment, have excellent mechanical properties, and control the degradation rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 70.845g Ca(NO 3 ) 2 4H 2 O was dissolved in 300ml deionized water, after it was completely dissolved, it was filtered through a No. 4 glass sand funnel and put into a 100ml open beaker; 76.04g Na 3 PO 4 12H 2 O was dissolved in 200ml deionized water, and after it was completely dissolved, it was filtered with a No. 4 glass sand funnel and put into a separatory funnel. Stir at room temperature and adjust with sodium bicarbonate to maintain pH 6.9-7.1, add the sodium phosphate solution dropwise to the calcium nitrate solution, and complete the addition in 20 minutes. Heating to 80°C for 2 hours, cooling and sealing naturally, after standing for 48 hours, removing the supernatant, and washing with deionized water 6 times to obtain nano-scale calcium phosphate slurry with a content of 3.75wt% and a Ca / P molar ratio of 1.51 ,spare.

[0022] Add the above-mentioned calcium phosphate slurry 1000g and caprolactam 45.2g, glycine 0.75g, leucine 1.31g, phenylalanine 2.475g, ...

Embodiment 2

[0024] The preparation of nano calcium phosphate slurry is the same as in Example 1.

[0025] Add nano-calcium phosphate slurry 1000g and caprolactam 45.2g prepared in the same manner as in Example 1 in the three-necked bottle, glycine 0.75g, leucine 1.31g, phenylalanine 2.475g, lysine 1.46g, proline was 2.875g, serine was 1.051g, and alanine was 1.782g. Stir and heat up to 70°C under nitrogen protection, caprolactam melted, continue stirring and heat up to 200°C and keep the temperature for 1 hour. The temperature was raised to 220°C for 0.5 hours of pre-polymerization, then the temperature was raised to 230°C for 1 hour of polymerization, and then cooled to room temperature to obtain 88.5 g of a light yellow complex product. Test results of the composite product obtained: the calcium phosphate content in the composite material is 40%; the compressive strength is 102Mpa, the tensile strength is 95Mpa, the bending strength is 74Mpa, and the modulus of elasticity is 2.5Gpa; aft...

Embodiment 3

[0027] The preparation of nano calcium phosphate slurry is the same as in Example 1.

[0028] Add nano-calcium phosphate slurry 1000g and caprolactam 45.2g prepared in the same manner as in Example 1 in the three-necked bottle, glycine 0.75g, leucine 1.31g, phenylalanine 2.475g, lysine 1.46g, proline was 2.875g, serine was 1.051g, and alanine was 1.782g. Stir and heat up to 70°C under nitrogen protection, caprolactam melted, continue stirring and heat up to 200°C and keep the temperature for 1 hour. The temperature was raised to 220°C for 5 hours of pre-polymerization, then the temperature was raised to 230°C for 4.5 hours of polymerization, and then cooled to room temperature to obtain 85 g of a light yellow complex product. Test results of the composite product obtained: the calcium phosphate content in the composite material is 40%; the compressive strength is 143Mpa, the tensile strength is 131Mpa, the bending strength is 115Mpa, and the modulus of elasticity is 8.5Gpa; af...

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Abstract

The invention provides a degradable bioactivity composite containing calcium phosphate and a preparation method thereof. The composite consists of calcium phosphate and a multiple amino acid polymer; wherein, the weight percentage of inorganic composition is not more than 50 percent and the residual substance is the multiple amino acid polymer which is formed by the polymerization of caprolactam and at least 5 other amino acids; wherein, the molar ratio of the caprolactam in the polymer is 40-90 percent and the respective molar ratio of other single amino acid is not less than 0.5 percent. During preparation, the caprolactam is mixed with all amino acids and dehydration is carried out under the protection of inert gases and stirring, and pre-polymerization composition reaction and polymerization reaction are respectively carried out at the temperature of 210-250DEG C, thus obtaining the composite. The indexes of the prepared material such as mechanic performance, degradation period and the like can be adjusted and controlled according to the use requirements.

Description

technical field [0001] The invention relates to a degradable bioactive medical composite material containing calcium phosphate and a preparation method thereof. Background technique [0002] Currently, bioactive medical composite materials containing calcium-containing phosphate inorganic components have been reported and / or used, including degradable and non-degradable materials. Degradable components such as Ca(H 2 PO 4 ) 2 (MCP), Ca 2 P 2 o 7 (CPP), CaHPO 4 2H 2 O(DCP), Ca 3 (PO 4 ) 2 (TCP), etc.; non-degradable components may include such as Ca 10 (PO 4 ) 6 (HO) 2 (HA), Ca 10 (PO 4 ) 6 O(OXA) and CaO·Ca 3 (PO 4 ) 2 (TTCP) etc. Due to its good bioactivity and biocompatibility, it has been widely used in the field of bone repair and bone reconstruction. In particular, tricalcium phosphate (TCP), which has a calcium / phosphorus ratio of 1.5 and is degradable, has excellent biological properties and can guide tissue growth, that is, it has osteoconductiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/12A61L27/58
Inventor 严永刚李鸿南景天罗小满黄志鹃何丽萍杨杰张其翼吕国玉杨爱萍
Owner SICHUAN UNIV
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