Method for preparing biological medical porous implant material

A technology for biomedical and implantable materials, applied in the field of medical implanted porous metal materials, can solve problems such as inability to meet needs, and achieve the effects of ensuring biocompatibility and biosafety, simple process and simple preparation method

Active Publication Date: 2012-11-28
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, high requirements are placed on the molding technology, and the traditional molding technology cannot meet the needs due to the limitation of the preparation process

Method used

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  • Method for preparing biological medical porous implant material
  • Method for preparing biological medical porous implant material
  • Method for preparing biological medical porous implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of a porous tantalum biomedical implant material is carried out as follows:

[0023] Mix 300 g of pure tantalum powder with a particle size of 8 μm and 40 ml of a polyvinyl alcohol aqueous solution with a mass concentration of 3%, and stir well to form a jelly. A 4cm×5cm×4cm polymer resin template bracket with a porosity of about 30% and complete three-dimensional connectivity was prepared by conventional 3D printing methods, and the polymer resin template bracket was put into a steel mold with a side length of 6cm. Then, the prepared jelly is poured into the steel mold, and the suspension is submerged in the polymer resin formwork support, and the steel mold is placed on a pressurizing device, so that the pressure around the steel mold is slowly and evenly increased. Within 3 hours, 0MPa rises to 8MPa, so that the powder is fully and tightly poured into the polymer resin template support, and the moisture in the jelly is penetrated during the press...

Embodiment 8

[0033] A preparation method of a porous tantalum biomedical implant material is carried out as follows:

[0034] a. Mix pure tantalum powder with a particle size of 8-10 μm and ethyl cellulose alcohol solution with a mass percentage concentration of 3-5% at a mass ratio of 5-7:1, stir well and evenly, and prepare a tantalum powder slurry;

[0035] b. Put the fully three-dimensionally connected polymer template bracket with a porosity of 20% to 50% into the steel mold, then pour the prepared tantalum powder slurry into the steel mold and flow over the polymer template bracket , and finally apply pressure slowly and evenly around the steel mold so that the tantalum powder is fully filled into the polymer template. The applied pressure is increased from 0MPa to 10Mpa at a constant speed. The particles are closely combined with each other, and the water in the tantalum powder slurry seeps out of the steel mold during the pressing process;

[0036] c. Put the remaining water in th...

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Abstract

The invention discloses a method for preparing a porous tantalum biological medical implant material. The method comprises the following steps of: uniformly mixing pure tantalum powder and a binding agent to obtain tantalum powder slurry; placing a high polymer resin template support which has the porosity of 20 to 50 percent and of which pores are completely communicated in a three-dimensional way in a steel die; pouring the prepared tantalum powder into the steel die until the high polymer resin template support is immersed; slowly and uniformly applying pressure to the periphery of the steel die to ensure that the tantalum powder can be fully and completely filled into the high polymer resin template support, wherein the applied pressure is increased from 0 Mpa to10 Mpa at constant speed, and the time required by the pressure application process is 2 to 5 hours; performing chemical dissolution to remove the high polymer resin template support to obtain a green body framework of porous tantalum; and performing aftertreatment such as degreasing, sintering and the like to obtain the biological medical porous tantalum implant material. A product prepared by the method is a green body of the porous metal material of which pores are completely communicated in the three-dimensional way, and the green body is sintered to form the porous metal implant material of which the pores are completely communicated in the three-dimensional way, so that the porous metal implant material is high in biocompatibility.

Description

technical field [0001] The invention relates to the field of forming and preparing porous medical metal implant materials, in particular to a medical implant porous metal material that replaces the bone tissue of a load-bearing part. Background technique [0002] Porous medical metal implant materials are used to replace relevant tissues of the human body, and have good therapeutic prospects. For example, they have important and special uses such as the treatment of bone tissue trauma and femoral tissue necrosis. Now such materials are metal stainless steel, porous metal titanium, etc. , porous tantalum, etc. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and evenly distributed, or partially connected and evenly distributed according to the needs, so that it can be connected with The growth of bone tissue in the human body is consistent, and the wei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/08C22C27/02A61L27/04A61L27/56B22F1/10
CPCB22F3/1137B22F1/0059B22F2301/20A61L2400/08A61L27/04B22F2999/00A61L27/56B22F3/1146A61L27/047C22C1/08C22C27/02B22F1/10B22F3/1021
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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