Preparation method of 3D printable iron ion double-crosslinked alginate-polyacrylamide acrylic acid high-performance hydrogel

A technology of polyacrylamide acrylic acid and alginate, applied in the direction of additive processing, can solve problems such as affecting the biocompatibility of stents, and achieve the effects of excellent self-healing performance, short preparation period and simple preparation process

Active Publication Date: 2018-07-13
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydrogels with different shapes and porosity can be obtained by adjusting the printing conditions, but the introduction of chemical cross-linking in the hydrogel scaffold affects the biocompatibility of the scaffold

Method used

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  • Preparation method of 3D printable iron ion double-crosslinked alginate-polyacrylamide acrylic acid high-performance hydrogel
  • Preparation method of 3D printable iron ion double-crosslinked alginate-polyacrylamide acrylic acid high-performance hydrogel
  • Preparation method of 3D printable iron ion double-crosslinked alginate-polyacrylamide acrylic acid high-performance hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Step 1): Weigh 0.4642g of sodium alginate (SA) into 15mL of deionized water, stir at 65°C and 500RPM for 20min at high speed to dissolve to obtain a uniform SA solution.

[0037] Step 2): Weigh 9.9512g AM, 0.5045g AAc, and 0.0215g KA into 5mL deionized water, stir and dissolve at 30°C to obtain a uniform transparent aqueous solution. This solution was added to the solution in step 1), and stirred at 50°C and 500RPM for 10min in a light-proof environment, and the molar concentration of SA was 0.1172mol / L, the molar concentration of AM was 7mol / L, and the molar concentration of AAc was 0.35mol / L, KA molar concentration of 0.00735mol / L mixed solution.

[0038] Step 3): inject the mixed solution obtained in step 2) into a glass mold under the condition of shading, and place the glass mold under ultraviolet light for 5-7 hours to obtain preliminary SA / P(AM-co-AAc) hydration glue.

[0039] Step 4): Soak the preliminary hydrogel obtained in step 3) in 0.06mol / LFe 3+ In the ...

Embodiment 2

[0042] Step 1): Weigh 0.6220g of sodium alginate (SA) into 15mL of deionized water, stir at 65°C and 500RPM for 20min at high speed to dissolve to obtain a uniform SA solution.

[0043] Step 2): Weigh 9.9512g AM, 0.5045g AAc, and 0.0215g KA into 5mL deionized water, stir and dissolve at 30°C to obtain a uniform transparent aqueous solution. This solution was added to the solution in step 1), and stirred at 50°C and 500RPM for 10min in a light-proof environment, and the molar concentration of SA was 0.157mol / L, the molar concentration of AM was 7mol / L, and the molar concentration of AAc was 0.35mol / L, KA molar concentration of 0.00735mol / L mixed solution.

[0044] Step 3): inject the mixed solution obtained in step 2) into a glass mold under the condition of shading, and place the glass mold under ultraviolet light for 5-7 hours to obtain preliminary SA / P(AM-co-AAc) hydration glue.

[0045] Step 4): Soak the preliminary hydrogel obtained in step 3) in 0.06mol / LFe 3+ In the s...

Embodiment 3

[0048] Step 1): Weigh 0.9426g of sodium alginate (SA) into 15mL of deionized water, stir at 65°C and 500RPM for 20min at high speed to dissolve to obtain a uniform SA solution.

[0049] Step 2): Weigh 9.9512g AM, 0.5045g AAc, and 0.0074g KA into 5mL deionized water, stir and dissolve at 30°C to obtain a uniform transparent aqueous solution. This solution was added to the solution in step 1), and stirred at 50°C and 500RPM for 10min in a light-proof environment, and the molar concentration of SA was 0.2381mol / L, the molar concentration of AM was 7mol / L, and the molar concentration of AAc was 0.35mol / L, KA molar concentration of 0.00735mol / L mixed solution.

[0050] Step 3): inject the mixed solution obtained in step 2) into a glass mold under the condition of shading, and place the glass mold under ultraviolet light for 5-7 hours to obtain preliminary SA / P(AM-co-AAc) hydration glue.

[0051] Step 4): Soak the preliminary hydrogel obtained in step 3) in 0.06mol / LFe 3+ In the ...

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Abstract

The invention discloses a preparation method of 3D printable iron ion double-crosslinked alginate-polyacrylamide acrylic acid high-performance hydrogel. The method comprises the following steps: firstly, evenly mixing sodium alginate, acrylamide, acrylic acid and a photo-initiator; pre-molding by using a mould or a 3D printing way; illuminating by using an ultraviolet lamp so as to realize copolymerization between an AAc monomer and an AM monomer; after the polymerization is completed, soaking a hydrogel scaffold into an Fe3<+> solution to form ionic cross-linking; finally, soaking the productinto deionized water for balancing so as to remove the unreacted monomers. Two networks are both Fe3<+> cross-linked, so that a common cross-linking point exists between the two networks, and the hydrogel is enabled to have excellent performance. In addition, the sodium alginate has good natural high polymer with good biocompatibility, and the viscosity is adjusted by adding a small amount of adhesive in a sol state, so that the hydrogel has good anti-collapse and rapid gelation characteristics; the hydrogel can be prepared into high porosity hydrogel with various complex structures by usinga 3D printing technology.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for preparing a 3D-printable iron ion double-crosslinked alginate-polyacrylamide acrylic acid high-performance hydrogel. Background technique [0002] Polymer hydrogels act as "soft and wet" materials composed of a "three-dimensional cross-linked network" and a large amount of water (50-90%), these properties make hydrogels widely used in biomedical, pharmaceutical and industrial applications, including Scaffolds for tissue engineering are known as the most potential human cartilage replacement materials. However, hydrogels usually have weak and brittle mechanical properties. The poor mechanical properties of hydrogels are due to the high water content of hydrogels, the uneven molecular chain structure, and the lack of effective energy dissipation mechanisms. Therefore, the mechanical properties of hydrogels limit the application of hydrogels in bio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/56C08F220/06C08F2/48C08J3/24C08J3/075C08L33/26C08L5/04C08K3/36B33Y70/00
CPCB33Y70/00C08F2/48C08F220/56C08F251/00C08J3/075C08J3/243C08J3/246C08J2333/26C08J2405/04C08K3/36C08F220/06
Inventor 李学锋王慧张高文龙世军舒萌萌张奕坤邱迪
Owner HUBEI UNIV OF TECH
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