Modified sodium hyaluronate gel for injection
A technology of sodium hyaluronate and hyaluronic acid, used in medical science, prosthesis, surgery, etc., to enhance stability and cohesion, maintain biocompatibility, and achieve good filling effects
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Embodiment 1
[0052] This embodiment investigates the influence of gel X with different crosslinking degrees on the properties of the gel of the invention. The preparation method is as follows:
[0053] (1) Dissolve 5.0 g of hyaluronic acid in 50 ml of NaOH solution (pH>10), mix well, add cross-linking agent 1,4-butanediol diglycidyl ether, cross-linking agent and hyaluronic acid The acid quality ratio is shown in Table 1, stir and mix well, and react in a water bath at 35°C for 10 h to obtain gel X;
[0054] (2) Dissolve 5.0 g of hyaluronic acid in 50 ml of NaOH solution (pH>9), mix well, add 1,4-butanediol diglycidyl ether, the mass ratio of crosslinking agent to hyaluronic acid is 0.06%, stir and mix well, and react in a water bath at 35°C for 8 hours to obtain gel Y;
[0055] (3) Mix gel X and gel Y at a ratio of 50% X-50% Y (50 g : 50 g), adjust the pH to 2~4, add 1,4-butanediol diglycidol Ether, the mass ratio of cross-linking agent to hyaluronic acid is 0.8%, react in a water bath ...
Embodiment 2
[0065] This embodiment investigates the influence of gel Y with different crosslinking degrees on the properties of the invented gel, and the preparation method is as follows:
[0066] (1) Dissolve 5.0 g of hyaluronic acid in 50 ml of NaOH solution (pH>10), mix well, add cross-linking agent 1,4-butanediol diglycidyl ether, cross-linking agent and hyaluronic acid The acid mass ratio was 2.5%, stirred and mixed, and reacted in a water bath at 35°C for 10 h to obtain gel X;
[0067] (2) Dissolve 5.0 g of hyaluronic acid in 50 ml of NaOH solution (pH>9), mix well, and then add 1,4-butanediol diglycidyl ether. 2, stir and mix well, and react in a water bath at 35°C for 8 h to obtain gel Y;
[0068] (3) Mix gel X and gel Y at a ratio of 50% X-50% Y (50 g : 50 g), adjust the pH to 2~4, add 1,4-butanediol diglycidol Ether, the mass ratio of cross-linking agent to hyaluronic acid is 0.8%, react in a water bath at 35°C for 6 h;
[0069] (4) Adjust the pH value of the gel to neutral w...
Embodiment 3
[0076] Compare the amount of crosslinker after mixing gel X and gel Y:
[0077] (1) Dissolve 5.0 g of hyaluronic acid in 50 ml of NaOH solution (pH>10), mix well, add 1,4-butanediol diglycidyl ether, the mass ratio of crosslinking agent to hyaluronic acid is 2.5%, stirred and mixed, and reacted in a water bath at 35°C for 10 h to obtain gel X.
[0078] (2) Dissolve 5.0 g of hyaluronic acid in 50 ml of NaOH solution (pH>9), mix well, add 1,4-butanediol diglycidyl ether, the mass ratio of crosslinking agent to hyaluronic acid is 0.06% (w / w), stirred and mixed, and reacted in a water bath at 35°C for 8 h to obtain gel Y.
[0079] (3) Mix gel X and gel Y at a ratio of 50% X-50% Y (50 g : 50 g), adjust the pH value to 2~4, add different ratios of 1 as shown in Table 3, 4-Butanediol diglycidyl ether was reacted in a water bath at 35°C for 6 h.
[0080] (4) Adjust the pH value of gel X to neutral with 0.5% NaOH solution, and then dialyze the gel in phosphate buffer with neutral pH...
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