Preparation method of grapheme/hydroxyapatite composite material

A technology of hydroxyapatite and composite materials, which is applied in the application field of nano-composite materials and biological materials, can solve the problems of increased preparation cost, physical health toxicity, long reaction time, etc., achieves excellent biocompatibility, and reduces environmental pollution. , to avoid the effect of toxic side effects

Inactive Publication Date: 2013-12-04
SOUTHWEST JIAOTONG UNIV
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  • Description
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Problems solved by technology

The ethylenediamine used in this method is a substance that is harmful to human health. Its addition will reduce the biocompatibility of HA, resulting in the possibility of biotoxicity of the composite material.
And both of the above two methods need to process graphene oxide in the early stage to obtain graphene material or graphene precursor, and then form HA on it to obtain graphene / HA composite material, which increases the reaction cycle and increases the Production costs, not conducive to mass production
Chinese patent CN201210055981.0 uses graphene oxide as a precursor and amino acid as a structure regulator to prepare graphene / HA nanocomposites by hydrothermal method, but this method adds amino acid as a structure regulator, which increases the preparation cost and takes a long time to react , of little significance for mass production

Method used

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  • Preparation method of grapheme/hydroxyapatite composite material
  • Preparation method of grapheme/hydroxyapatite composite material
  • Preparation method of grapheme/hydroxyapatite composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of preparation method of graphene / hydroxyapatite composite material, concrete steps are as follows:

[0025] 1) Mix graphene oxide with a concentration of 0.5 mg / ml and a calcium nitrate solution with a calcium ion concentration of 1.0 mol / L to obtain a mixed solution 1, and then mix phosphoric acid with a calcium / phosphorus molar ratio of 1.67:1. The disodium hydrogen phosphate dodecahydrate solution with a root ion concentration of 0.67mol / L was added to the mixed solution 1 under the action of magnetic stirring and mixed evenly, and the pH was adjusted to 8 with a pH regulator—urea, to obtain the mixed solution 2 ;

[0026] 2) Transfer the mixed solution 2 into a reaction kettle, heat it at 180°C for 2 hours for hydrothermal treatment, then cool to room temperature, centrifuge, wash and freeze-dry to obtain a graphene / hydroxyapatite composite material.

[0027] figure 1 The X-ray diffraction patterns of graphene oxide (Graphene Oxide, GO), graphene (Reduced-...

Embodiment 2

[0031] This example is basically the same as Example 1, the difference is:

[0032] The suspension with calcium ion concentration of 0.1mol / L is calcium hydroxide suspension, the phosphate solution is dipotassium hydrogen phosphate, and the pH regulator is sodium hydroxide.

Embodiment 3

[0034] This example is basically the same as Example 1, the difference is:

[0035] The suspension with a calcium ion concentration of 0.25 mol / L is calcium carbonate suspension, the phosphate solution is potassium dihydrogen phosphate, and the pH regulator is potassium hydroxide.

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Abstract

A preparation method of a grapheme/hydroxyapatite composite material comprises the following steps: uniformly mixing oxidized grapheme with the concentration of 0.5-5 mg/ml and a solution or a turbid liquid with the calcium ion concentration of 0.01-3.0 mol/L to obtain a first mixed solution; adding a solution I with the phosphate anion concentration of 0.01-2.0 mol/L to the first mixed solution according to the molar ratio of calcium to phosphorus is (1.5-2.0) to 1, and uniformly mixing the solution I and the first mixed solution under the action of magnetic mixing; adjusting the pH to be 8-14 through a pH adjusting agent to obtain a second mixed solution; transferring the second mixed solution to a reaction kettle; carrying out hydro-thermal treatment for 1-12 hours at the temperature of 160-240 DEG C; cooling the second mixed solution until the temperature of the second mixed solution is the room temperature; cleaning, freezing and drying to obtain the grapheme/hydroxyapatite composite material. The preparation method is environment-friendly, simple and beneficial to large-scale production. The prepared grapheme/hydroxyapatite composite material has the advantages of good mechanical property as well as high electrical conductivity, adsorbability, biocompatibility and osteogenic activity.

Description

technical field [0001] The invention relates to a graphene / hydroxyapatite composite material and a preparation method thereof, belonging to the application field of nanocomposite materials and biological materials. Background technique [0002] Hydroxyapatite (HA) is a typical biomaterial, the main inorganic component of human bone tissue and teeth, has good biocompatibility and osteogenic activity, and is recognized as a good candidate in the field of bone repair and replacement Bone replacement biomaterials. However, as a bone repair material, HA also has disadvantages such as high brittleness, poor load bearing capacity, and inability to adapt well to different application requirements of clinical bone repair. To solve this problem, HA is often compounded with other materials to achieve the purpose of enhancing mechanical properties. [0003] Graphene (Graphene), as an emerging nanoscale material, has excellent electrical, mechanical, optical and thermal properties, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B31/04C01B25/32C01B32/194
Inventor 卢晓英王先福张苗彭章翁杰
Owner SOUTHWEST JIAOTONG UNIV
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