Functionalized implantable flexible electrode and application thereof

A flexible electrode and implantable technology, applied in the direction of electrodes, head electrodes, heart electrodes, etc., can solve the problems of neuron damage, failure to meet long-term implantation, and affect the performance of nerve electrodes

Pending Publication Date: 2019-02-19
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Microglia are then activated, and then secrete reactive oxygen species and inflammatory cytokines, some of which are toxic, so their adjacent neurons may be damaged, which seriously affects the performance of nerve electrodes and cannot meet the purpose of long-term implantation

Method used

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  • Functionalized implantable flexible electrode and application thereof
  • Functionalized implantable flexible electrode and application thereof
  • Functionalized implantable flexible electrode and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment provides a functionalized implantable flexible electrode, which is a functionalized wide-width electrode. The electrode includes a stimulating end, a lead part and a functional end, and its total length is 6 cm. The stimulating end and the functional end are passed through the lead wire Partial connection. Among them, the stimulation end is rectangular, with a length of 1.2 cm and a width of 0.6 cm. The area of ​​the stimulation area is 1.2 cm × 0.6 cm. The diameter of a single stimulation site in the stimulation end is 300 μm, the height is 80 μm, and the distance between stimulation sites is 412.5 μm, the number of stimulation channels is 126; the lead part is rectangular, 4cm long, 0.4cm wide, and the lead spacing is 10μm; the functional end is rectangular, 1.2cm long, 0.6cm wide. The stimulation site array of the stimulation end of the electrode is as figure 1 shown.

[0047] The stimulating end of the implantable flexible electrode includes a base...

Embodiment 2

[0059] This embodiment provides a functionalized implantable flexible electrode, the electrode has a stimulating end and a lead part of the stimulating end, and the length of the electrode is 6 cm. Among them, the stimulation end (stimulation area) is a rectangle with an area of ​​1.2cm×0.9cm, the diameter of a single stimulation site in the stimulation end is 150 μm, the distance between stimulation sites is 260 μm, and the number of stimulation channels is 1000. The local structure of the stimulation end Such as Figure 5 shown. The area of ​​the lead part is 1.2cm×0.2cm, the distance between the leads is 10μm, and the width of a single lead is 5μm.

[0060] The stimulating end of the electrode is composed of a base layer (compounded with functional materials that can form current through light) and a conductive layer, and the stimulating site of the stimulating end is decorated with an electroplating layer and a biological material modification layer. The graft has a poly...

Embodiment 3

[0070] This embodiment provides functionalized implantable flexible electrodes, such as Image 6 shown. The electrode includes a stimulating end, a lead part and a functional end, the total length of which is 6 cm, and the width is 0.8 cm. Among them, the stimulation area of ​​the stimulation end is 0.8cm×1.5cm, the diameter of a single stimulation site in the stimulation end is 500 μm, the distance between stimulation sites is 750 μm, and the number of stimulation channels is 10. The lead part is rectangular, its length is 3.0 cm, its width is 0.8 cm, and the lead wire spacing is 0.5 mm. The area of ​​the functional end is 0.8cm×1.5cm.

[0071] The stimulating end of the electrode includes a base layer and a conductive layer. The material of the base layer is polydimethylsiloxane, and its thickness is 10 μm; the material of the conductive layer is gallium indium alloy, and its thickness is 1 μm; The stimulation site is decorated with a biological material modification laye...

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Abstract

The invention relates to a functionalized implantable flexible electrode and an application thereof. The functionalized implantable flexible electrode at least comprises a function layer capable of generating a current or voltage. In the invention, through adopting the function layer which can generate the current or the voltage via triggering, the flexible electrode does not need complex line connection and device packaging and the function of a nerve stimulation device can be realized so that an operation risk and the safety risk of long-term implantation are greatly reduced, and the application field of the nerve stimulation device is expanded. The invention also provides the applications of the above functionalized wide-width implantable electrode in manufacturing an implantable artificial retina, an implantable artificial cochlea, an implantable cardiac pacemaker, and an implantable deep brain stimulator.

Description

technical field [0001] The invention relates to a functional implantable flexible electrode and its application, in particular to a functional implantable flexible electrode with a functional layer capable of forming current or voltage through triggering and its application, belonging to the technical field of biomaterials. Background technique [0002] With the continuous acceleration of the pace of life, because people are often in a state of high physical and mental tension, neurological diseases such as retinitis pigmentosa, macular degeneration, depression, and epilepsy are increasing day by day. At the same time, global aging has exacerbated the probability of neurological diseases and become a major social burden. [0003] The rapid development of wearable or implantable nerve electrical stimulation therapy and the appearance of neural prosthesis have brought new hope to the majority of patients. Nerve electrical stimulation therapy is a treatment method that regulat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/05A61L31/14C08F283/04C08F212/14C08F220/54C08F230/08
CPCA61L31/14A61N1/0534A61N1/0541A61N1/0543A61N1/056A61N1/0587C08F283/045C08F230/08C08F212/14
Inventor 杜学敏崔欢庆
Owner SHENZHEN INST OF ADVANCED TECH
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