Method for preparing medical polymer material by ion implantation technique

A technology of polymer materials and ion implantation equipment, applied in the field of medical polymer materials processing, can solve the problem of neglecting material performance requirements, failing to solve the problem of surface infection of silicone rubber, and failing to solve the problem of biocompatibility of anti-infection performance on the surface of materials, etc. It can be beneficial to the growth and reproduction of cells and tissues, improve the anti-infection performance, and ensure the effect of biocompatibility.

Active Publication Date: 2013-04-17
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After retrieval, at present, the method of improving the blood compatibility and safety of artificial heart valve leaflet materials by Liu Xianghuai, Wang Xi et al. (publication number: CN1385142A) uses the ion implantation method to modify the surface of medical materials. Injected into the surface of heart valve leaflets made of pyrolytic carbon, this method only improves the blood compatibility of the material, and does not solve the problem of anti-infection performance of the material surface and biocompatibility with tissues; Zhang Yiming, Chen Yu etc. invented the surface modification method of medical silicone rubber (publication number is: CN101880402A), this method implants carbon ions into the surface of silicone rubber, and achieves tissue compatibility by improving its surface hydrophilicity, and does not solve the problem of silicone rubber surface modification. Infection problem; For another example, people such as Zhao Jie, Liu Qianxiang reported the method (published number is: 1827840) of preparing silver-rich antimicrobial film on medical pyrolytic carbon and TiN thin film, and this method is to only inject silver ion into pyrolysis Carbon and TiN film to achieve antibacterial effect
It can be seen that there are few patents on ion implantation reported at present, and they are mainly aimed at metal alloys and carbon materials, rather than medical polymer materials; and they only focus on improving the performance of a certain aspect of the material. Other aspects of the performance requirements of the material are ignored

Method used

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  • Method for preparing medical polymer material by ion implantation technique
  • Method for preparing medical polymer material by ion implantation technique
  • Method for preparing medical polymer material by ion implantation technique

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of medical polymer materials by ion implantation technology includes the following steps:

[0041] Move the polyethylene film with a thickness of 1 μm through the processing table in the vacuum chamber of the ion implantation equipment at 1 m / min, install the silver electrode on the ion implantation machine, then seal the vacuum chamber of the equipment, and evacuate to 1×10 -5 Pa, through 10.0SCCM of nitrogen and 10.0SCCM of argon, and finally maintain the working vacuum at 1×10 -2 Around Pa, turn on the Hall plasma source with a power of 300W, and at the same time turn on the power of the ion implanter, the accelerating voltage is 15KV, and the ion implantation dose is 1×10 15 ~1×10 17 ions / cm 2After the treatment, turn off the power of the ion implanter and the Hall plasma source, ventilate the atmosphere to return the vacuum chamber to the atmospheric pressure, and obtain the desired anti-infection and biocompatible polyethylene film.

[0042] fi...

Embodiment 2

[0049] The preparation of medical polymer materials by ion implantation technology includes the following steps:

[0050] Fix the PLA film with a thickness of 0.5 μm on the processing table in the vacuum chamber of the ion implantation equipment, install the silver electrode and the zinc electrode on the ion implantation machine, then seal the vacuum chamber of the equipment, and evacuate to 5×10 -6 Pa, pass through 5.0SCCM of ammonia, 5.0SCCM of acetic acid gas and 10.0SCCM of argon, and finally maintain the working vacuum at 5×10 -3 At about Pa, turn on the radio frequency plasma source, the power is 500W, and after 5 minutes of treatment, turn on the power of the ion implanter, the accelerating voltage is 30KV, and the ion implantation dose is 1×10 16 ~5×10 16 ions / cm 2 , after 5 seconds of treatment, turn off the power of the ion implanter and the radio frequency plasma source, and keep it under this condition for 60 minutes, ventilate the atmosphere to return the vacuum...

Embodiment 3

[0053] The preparation of medical polymer materials by ion implantation technology includes the following steps:

[0054] Move the polyamide-66 artificial intervertebral body support at 2 m / min through the processing table in the vacuum chamber of the ion implantation equipment, install each of the silver electrode, graphite electrode and phosphorus electrode on the ion implantation machine, and then seal the equipment vacuum chamber, and evacuated to 5 x 10 -4 Pa, through 10.0SCCM of nitrogen, 5.0SCCM of acetylene gas and 5.0SCCM of argon, and finally maintain the working vacuum at 1×10 -4 At about Pa, turn on the Hall plasma source, the power is 800W, after 10 minutes of treatment, turn on the power of the ion implanter, the accelerating voltage is 30KV, and the ion implantation dose is 1×10 17 ~5×10 17 ions / cm 2 , after the treatment, turn off the power of the ion implanter, and keep it for 5 minutes, then turn off the power of the Hall plasma source, and keep it for 2 h...

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Abstract

The invention discloses a method for preparing a medical polymer material by an ion implantation technique; the method obtains the medical polymer material with surface infection resistance and biocompatibility by the following steps of fixing the medical polymer material on or moving the medical polymer material through a treatment table of ion implantation equipment, vacuum-pumping, introducing gas, turning on the power supply of the ion implantation equipment, and performing treatment. The method is simple in operation, and does not influence the physical-chemical structure of the material body; the treated polymer material is stable in surface structure, has long-acting and wide-spectrum infection resistance, and has cytocompatibility not lower than the inherent biocompatibility of the material itself.

Description

technical field [0001] The invention relates to a processing method for medical polymer materials, in particular to a method for preparing medical polymer materials with high infection resistance and biocompatibility by ion implantation technology. Background technique [0002] Medical polymer materials such as wound dressings, burn dressings, wound dressings, surgical gowns, surgical sheets, patient clothes, medical polymer interventional devices, etc. are all made of polyester polymers, polyolefin polymers, poly It is developed from carbohydrate polymers, polyurethanes, cellulose and other polymers. In actual use, these materials are in contact with wounds, scalded skin, and internal tissues, but they often cause infection or inflammation in wounds or tissues due to their lack of anti-infection properties and poor biocompatibility, which further leads to wound healing and tissue regeneration difficulties. For example, the wound dressing is polylactic acid electrospun non...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C23C14/48C23C14/20
Inventor 张维季君晖
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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