Method for synthesizing 2-amino-5-chlorobenzophenone by microchannel reactor

Abstract

The invention discloses a method for synthesizing 2-amino-5-chlorobenzophenone by a microchannel reactor, belongs to the field of synthesis of psychoactive drugs in organic synthesis, and solves the problems of low yield, poor purity, high risk of violent explosion, degradation caused by high reaction time under high temperature and high pressure conditions, low frequency of catalyst recycling andreuse and the like during the synthesis of a traditional catalytic hydrogenation reactor. The method for synthesizing the 2-amino-5-chlorobenzophenone in the microchannel reactor specifically includes the following steps: 1). adding hydrogenation reaction precursor 5-chloro-3-phenyl-2,1-benzisoxazole into an organic solvent, and then adding an activated-carbon-loaded noble metal catalyst to obtain a mixture as a material I to enter a preheating module of the microreactor; and 2). after preheating of the material I, injecting the material I and material II hydrogen into a reaction module groupof the microreactor for reaction, collecting a reaction solution flowing out from a cooling module, and treating to obtain the 2-amino-5-chlorobenzophenone. The method is suitable for the large-scaleproduction of the 2-amino-5-chlorobenzophenone.

Description

technical field [0001] The invention belongs to the field of synthesis of psychotropic drugs in organic synthesis, and in particular relates to a synthesis method of 2-amino-5-chlorobenzophenone. Background technique [0002] 2-Amino-5-chlorobenzophenone is an important intermediate for the synthesis of diazepam, chlordiazepoxide, oxazepam and other benzodiazepine hypnotic and sedative drugs. Diazepine hypnotic and sedative drugs are mainly used in Treatment of anxiety and various functional neurosis, insomnia, especially anxiety insomnia treatment is excellent. At the same time, 2-amino-5-chlorobenzophenone derivatives are widely used in anti-cancer, anti-mitosis, receptor antagonists, anti-osteoporosis, etc., and are also important raw materials for the synthesis of quinoline by the Friedlander method. As a very commonly used and important intermediate in the field of medicine and chemical industry, the advantages and disadvantages of its synthesis method are of great eco...

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of low yield, poor purity, danger of violent explosion, long reaction time at high temperature, degradation of catalyst, and low frequency of catalyst recycling in the synthesis process of traditional catalytic hydrogenation reactor, the present invention provides a microchannel The method that reactor synthesizes 2-amino-5 chlorobenzophenones, chemical reaction formula is as follows:

Images