7 results about "Corneal ulcer" patented technology

The invention discloses a neurological critical patient eye moisturizing nursing device which comprises an intelligent control host and an eye nursing unit, the host is placed beside a sickbed, an output pipeline of an atomization generation module in the host penetrates through a cabinet body, extends to a mounting plate and is communicated with an eye cup, the module is electrically connected with a central control module, and atomization starting and stopping and atomization amount adjustment can be achieved; and a built-in sensor acquires operating parameters and transmits the operating parameters to the monitoring module, so that a basis is provided for regulation and control. The eye nursing unit comprises a mounting ring with a first plastic connecting piece, an eye cup and a nursing executing mechanism, a mounting plate of the executing mechanism is fixed through a threaded column, a slidable sliding block driven by a gear and a motor is arranged at the lower end of the plate, and a second plastic connecting piece connected with the sliding block is matched with a silica gel protecting sleeve and can force eyelids to be closed. The electric push rod can adjust the distance between the side plates to adapt to different patients. The device is high in adaptability, can maintain cornea moist, remarkably reduces the incidence rate of keratitis and corneal ulcer, and is suitable for intensive care scenes.

The application discloses a corneal ulcer classification and identification method based on a Mobile ViT network, and belongs to the technical field of corneal ulcer classification and identification, and comprises the following steps: S1, sample pretreatment; S2, adding an attention mechanism; S3, feature splicing; S4, network building; S5, network training; and S6, classification and identification.The application adds an SE attention module in the original Mobile ViT network, enhances the ability of the network to extract important features, and suppresses unnecessary features; local feature maps are extracted from the original Mobile ViT network, and the local feature maps are fused with global feature maps to extract more effective features, and meanwhile, information exchange between various features is increased; various comparative experiments prove the effectiveness of the improvement, and successfully increase the accuracy from 88.7% to 91.5%.

This invention discloses an injectable AuPd-Fe single-atom nanozyme composite drug-derived antibacterial hydrogel, its preparation method, and its applications, belonging to the field of biomedical nanomaterials technology. This invention uses an iron-based single-atom nanozyme with an irregular octahedral carbon framework structure as the core catalytic carrier, and in situ loads ultra-small AuPd alloy nanoparticles onto its surface to obtain the AuPd-Fe single-atom nanozyme. Then, using the AuPd-Fe single-atom nanozyme as the active center and oleanolic acid drug-derived hydrogel as the delivery carrier, the AuPd-Fe single-atom nanozyme is uniformly dispersed in the three-dimensional network of the OA hydrogel through physical embedding and hydrogen bonding, resulting in the injectable AuPd-Fe single-atom nanozyme composite drug-derived antibacterial hydrogel. The provided antibacterial hydrogel exhibits excellent ocular surface biocompatibility, no significant corneal toxicity, and no systemic organ damage. It also shows significant clinical application potential for blinding ocular infections such as drug-resistant bacterial keratitis and corneal ulcers.

To provide a composition for use in a method of treating an IL-4 / IL-13 related disorder.SOLUTION: Provided is a composition for use in a method of treating an eye-related disorder in a subject in need thereof with an anti-interleukin-4 receptor α (anti-IL-4Rα) antibody, wherein the eye-related disorder is selected from dry eye, blepharitis, cicatricial pemphigoid, Mooren's corneal ulcer, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia, phacoanaphylaxis endophthalmitis, or a combination thereof, and wherein the method comprises administering a therapeutically effective amount of the anti-IL-4Rα antibody to the subject.SELECTED DRAWING: Figure 2

The present invention relates to a sterile ophthalmic composition comprising castor oil and medium-chain triglycerides; to the use of said composition in medicine, in particular for the treatment and / or prevention of an ocular disease selected from the group consisting of dry eye, conjunctivitis, dermatitis, blepharitis, entropion, lax eye lid syndrome, thyroid eye disease, pterygium, conjunctival laxity, epithelial damage caused by preservatives, epithelial or anterior chamber damage caused by ocular surgery, corneal limbal cell deficiency, corneal ulceration caused by physical or chemical agents, keratitis, sub-scleritis and uveitis.

The utility model belongs to the technical field of ophthalmology medical instruments, and particularly relates to a protective eyeshade for exposed corneal ulcers, which comprises an eyeshade body, the whole shape of the eyeshade body adopts the profiling design of the shape of the eye socket of a human body, a lining of the eyeshade body is a hydrogel lining, two sides of the eyeshade body are provided with fitting parts, and the fitting parts are connected with the eyeshade body. The attaching portion is fixedly connected with the edges of the two sides of the eyeshade body, the attaching portion is made of low-sensitivity adhesive tape and used for being attached to the skin, a preservative film layer is arranged in the eyeshade body, a sealing ring is arranged on the edge of the eyeshade body, a double-arch-shaped protective layer is arranged on the outer side of the eyeshade body, and a buffering interlayer is further arranged on the inner side of the protective layer. According to the eye protection mask, wearing comfort can be guaranteed, the design fits eye sockets, a patient can wear the mask more comfortably, the weight is relatively light, a protection layer with buffering capacity is arranged outside the mask, the eyes of the patient can be protected, and long-time wetting can be guaranteed through hydrogel.

The invention discloses a stem cell exosome preparation for xerophthalmia or eye ulcer and a preparation method of the stem cell exosome preparation, and belongs to the technical field of biological medicine. The method comprises the following steps: carrying out low-intensity ultrasonic pulse treatment on the mesenchymal stem cells by adopting a pretreatment culture medium containing interferon-gamma and tumor necrosis factor-alpha; removing the pretreated culture medium, replacing the pretreated culture medium with a serum-free culture medium for continuous culture, collecting a culture solution, performing differential centrifugation, and collecting supernate; concentrating the supernate by using a tangential flow filtration system to obtain a concentrated solution; and loading the sample to a size exclusion chromatographic column for purification, and collecting an eluent to obtain the stem cell exosome. The invention discloses a stem cell exosome preparation for xerophthalmia or eye ulcer and a preparation method of the stem cell exosome preparation. A novel biological preparation which can be produced on a large scale and is safe and effective is provided for clinical treatment of xerophthalmia and corneal ulcer.