4 results about "Thiazolidines" patented technology

The invention relates to the technical field of biological medicine, in particular to a synthesis method and application of pinenyl thiazolidone derivatives, and the synthesis method comprises the step of synthesizing thiosemicarbazide A at the yield of 90% under the promotion of hydrochloric acid through condensation reaction between myrtenal and 4-methyl-3-thiosemicarbazide. Cyclizing the compound A and chloroacetic acid to obtain a key intermediate thiazolidone B; then, the intermediate reacts with substituted benzaldehyde, and the target compound C1-C13 is obtained. The adopted substrate myrtenal has a better anti-proliferation effect on malignant cells, strong water solubility is enhanced by introducing thiazolidines, and remarkably enhanced anti-cancer activity can be shown by introducing the thiazolidine derivative modified by Schiff base. The series of products are novel in structure, high in yield, simple in separation and purification operation and suitable for mass production, and part of products such as C5 have good biological activity.

In some aspects, this disclosure relates to methods for preparing cysteine ​​source solutions containing thiazolidinediones. In some other aspects, this disclosure relates to methods for using these cysteine ​​source solutions (such as in the preparation of cell culture media, cell culture, and / or peptide production), and systems and kits comprising these cysteine ​​source solutions.

The present disclosure, in some aspects, is directed to methods of making cysteine source solutions comprising a thiazolidine. In certain other aspects, the present disclosure is directed to methods of using the cysteine source solutions (such as in making a cell culture medium, performing cell culture, and / or producing a polypeptide), and systems and kits comprising the cysteine source solutions.

The present disclosure, in some aspects, is directed to methods of making cysteine source solutions comprising a thiazolidine. In certain other aspects, the present disclosure is directed to methods of using the cysteine source solutions (such as in making a cell culture medium, performing cell culture, and / or producing a polypeptide), and systems and kits comprising the cysteine source solutions.