Compound capable of inhibiting zinc ion metalloproteinases

A metalloprotease and compound technology, applied in the preparation of organic compounds, active ingredients of heterocyclic compounds, active ingredients of carbohydrates, etc., can solve problems such as failure of clinical tests, impact on normal physiological functions, and low specificity of inhibitors
CN1837169AInactive Publication Date: 2006-09-27房学迅
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
房学迅
Publication Date
2006-09-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a 1,2,3-trihydroxy benzene and derivant or pharmacy acceptable salt for zinc ion metal-prolease inhibition, which is characterized by the following: theses compounds is used for selective depressant of zinc ion metal-prolease (such as MT1-MMP, gelatinase A, B and collagenase, matrilysins, metal-elastase and stromelysin-1); these depressants can adjust physiological and pathology course with MMPs, ADAMs, ADAM-TS such as vessel rebirth, wound healing, organ transplantation, fecundation course and reactivation capability, rebuilding bone and ache, which is used for treating cancer, cardiovascular disease, arthritis, periodontal disease, multiple sclerosis, inflammation, adenomyosis, cornea ulcer, bacterial meningitis, diabetic syndrome, kidney disease, nerve retrogression disease, AIDS, bleb, anaphylaxis, adenomyosis, osteoporosis, asthma and so on; theses blocking agents can be used for antisenescence, antibiosis, commercial manufacture addition agent of cell epimatrix, collagen product, cosmetics and make-up preparation, which can used for animals and other living bodies.
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Description

technical field

[0001] The invention relates to a compound capable of inhibiting zinc ion metalloprotease, its use and a pharmaceutical composition containing the compound. Background technique

[0002] Matrix metalloproteinases, namely Matrix Metalloproteinases, MMPs for short, are Zn 2+ Generic term for a family of metalloendopeptidases involved in the degradation of the extracellular matrix (ECM). MMPs are a Zn 2+ Dependent protease family, mainly synthesized and secreted by fibroblasts, endothelial cells, macrophages, neutrophils, etc., usually under neutral conditions and Ca 2+ To play a role with participation, 23 kinds of human MMPs have been discovered so far. Various MMPs generally have the following characteristics: ① The cDNA sequences of different MMPs have homology. ② They are all secreted in the form of zymogens, activated by proteases or other factors, and can degrade one or more ECMs after activation. ③ Enzyme activity depends on Zn in the active center ...

Claims

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