Eye drops containing chitosan derivative

A technology of eye drops and derivatives, applied in the direction of drug combination, sensory disease, etc., can solve the problems of side effects and restrictions on wide application, and achieve the effect of improving curative effect, obvious curative effect, and long residence time

Inactive Publication Date: 2003-03-19
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
View PDF1 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan can only be dissolved in acidic solution, and the application of acidic so

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Based on 1000ml of eye drops, dissolve 3g of carboxymethyl chitosan in an appropriate amount of distilled water, and make it dissolve for later use. Weigh 3 g ofloxacin, 20 g glycerin, 0.2 g sodium edetate, and 3 g sodium chloride, dissolve them in another appropriate amount of distilled water, add them to the carboxymethyl chitosan aqueous solution dissolved in advance, and mix After uniformity, add distilled water to 1000ml, filter and sterilize with a 0.2 μm microporous membrane, seal after subpackaging, and obtain the eye drops of the present invention, pH=7.2.

Embodiment 2

[0023] Based on 1000ml of eye drops, dissolve 2g of carboxybutyl chitosan in an appropriate amount of distilled water, and make it dissolve for later use. Weigh 2.5g ofloxacin, 25g glycerin, 0.2g sodium edetate, and 7g sodium chloride, dissolve them in another appropriate amount of distilled water, add them to the carboxybutyl chitosan aqueous solution dissolved in advance, and mix After uniformity, add distilled water to 1000ml, filter and sterilize with a 0.2 μm microporous membrane, seal after subpackaging, and obtain the eye drops of the present invention, pH=7.3.

Embodiment 3

[0025] Based on 1000ml of eye drops, dissolve 4g of hydroxyethyl chitosan in an appropriate amount of distilled water, and make it dissolve for later use. Weigh 3g ofloxacin, 20g glycerin, 0.2g sodium edetate, and 12g sodium chloride, dissolve them in another appropriate amount of distilled water, add to the pre-dissolved hydroxyethyl chitosan aqueous solution, and mix well Then add distilled water to 1000ml, filter and sterilize with a 0.2 μm microporous membrane, seal after subpackaging, and obtain the eye drops of the present invention, pH=6.9.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to medicine technology, and is one kind of eye drops for treating conjunctivitis, keraritis, corneal ulcer, xerophthalma and other eye diseases. The eye drops contains water soluble chitosan derivative and medicinal active component, proper amount of pH controlling agent and osmotic pressure regulator. It has delayed releasing and long acting function and thus high biological medicine utilization and clinical curative effect.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular, the invention belongs to an eye drop containing chitosan derivatives. Background technique [0002] With the quickening of the pace of life, the abnormal climate and the improvement of the computer penetration rate, the incidence of various eye diseases is also increasing. At present, there are mainly three types of eye drops for clinical treatment of eye diseases: one is to directly dissolve antibiotics or antiviral drugs in distilled water, and then make them into a certain concentration to treat eye diseases clinically. After this type of preparation is instilled into the eyes, the residence time of the active ingredients of the medicine is short, the bioavailability of the medicine is low, and the therapeutic effect is not good; However, it blocks the line of sight and is very inconvenient to use; another is to add a thickener to the usual eye drops to increase the residence...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/36A61P27/02
Inventor 王爱勤汪琴韦平
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap