Gatifloxacin external and ophthalmic gel preparation

A technology of gatifloxacin and ophthalmic gel, which is applied in the field of external application and ophthalmic gel preparations, can solve problems such as cross-resistance, achieve strong antibacterial activity, promote tissue growth and wound healing, and good film formation sexual effect

Inactive Publication Date: 2003-10-15
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, cross-resistance between the above drugs often occurs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: It is an external gel preparation of the present invention, which consists of: 10 g of gatifloxacin, 15 g of chitosan, an appropriate amount of hydrochloric acid (0.1 mol / L), and 1000 ml of sterilized water for injection. The preparation method is as follows: adding chitosan to water for injection with 80% of the prescription amount, adding an appropriate amount of hydrochloric acid to dissolve it; adding gatifloxacin, stirring and dissolving, adjusting the pH value to 4.6-5.6 with 0.1mol / L hydrochloric acid, Add water to the full amount, stir well, filter, and pack in aluminum tubes, each with 10ml.

[0021] Gatifloxacin in the present invention is a quinolone drug. Gatifloxacin is a new generation of quinolone antibacterial drugs developed by Bumei Squibb Pharmaceutical Company of the United States, Kyorin Company of Japan and Gruenenthal Pharmaceutical Company of Germany. In the first and second quarters of 1999, the new drug application of the drug ha...

Embodiment 2

[0022] Embodiment two: be a kind of ophthalmic gel preparation of the present invention, it is composed of: gatifloxacin 5g, chitosan 10g, boric acid 16g, sodium chloride 8g, hydrochloric acid (0.1mol / L) appropriate amount, sterile injection Make up to 1000ml with water. The preparation method is as follows: dissolving boric acid in water for injection with 80% of the prescription amount, adding chitosan, stirring to dissolve; adding gatifloxacin and sodium chloride, stirring to dissolve, and adjusting the pH value with 0.1mol / L hydrochloric acid To 4.6-5.6, add water to the full amount, stir well, filter, pack in aluminum tubes, each tube contains 10ml, and sterilize with 100°C circulating steam for 30 minutes to obtain.

[0023] The remaining dosage groups can be made by adjusting the prescription according to the routine with reference to the above-mentioned examples.

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PUM

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Abstract

The Gatifloxacin gel preparation for external use and eye use has Gatifloxacin as main component and its supplementary material includes chitosan as gel substrate, iso-osmotic regulator, pH regulator, preservative, injection water, etc. The preparation has Gatifloxacin content of 0.1-3 wt% and chitosan content of 0.3-3 wt%. It has obvious anti-infection function and functions of speeding heal of wound, promoting epidermal growth, inhibiting formation of scar tissue, maintaining local medicine density for long term, etc. It is used in treating burns, scalds, skin infection, folliculitis, bacterial conjunctivitis, keratitis, etc.

Description

technical field [0001] The invention relates to a gel preparation for external use and ophthalmic use. Background technique [0002] At present, it is widely used in the clinical treatment of burns, skin infections, folliculitis, boils, impetigo, trauma infection, eczema infection, gynecological vaginitis, cervicitis and treatment of eye diseases. There are drugs for the treatment of bacterial infections, such as tetracycline ointment for external use, ofloxacin ointment, ofloxacin eye drops for ophthalmology, norfloxacin eye drops, Runshu eye drops, etc. The main pharmacological effects of these varieties are Inhibit pathogenic microorganisms, thereby treating and preventing infection; but it does not have the function of promoting tissue healing and inhibiting scar tissue; and most ophthalmic preparations are eye drops; The drug in the conjunctival sac will be quickly diluted by tears and discharged from the nasolacrimal duct, so that the concentration of the drug on the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/496A61P17/02A61P27/02
Inventor 陆宏国何凌云顾孝红谷陟欣
Owner YANGTZE RIVER PHARM GRP CO LTD
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