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In-vivo gel preparatino able to be dropped in eyes and its preparing process

A technology of body gel and preparation, which is applied in the field of eye drop body gel preparation and its preparation, which can solve the problems of affecting the appearance and vision, the difficulty of uniform distribution of drugs, and the inability to accurately control the dosage, etc., to achieve significant anti-infection Effect, easy and accurate control of dose, and effect of improving compliance and tolerance

Inactive Publication Date: 2003-02-19
SHANGHAI XINGKANG PHARMA RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also ophthalmic gel products on the market, but most of them are viscous and semi-solid. If the gel is directly dropped into the eye, the drug is not easy to distribute evenly due to the lack of good spreadability of the gel in the eye. It cannot be controlled accurately, and it may affect the appearance and vision, which needs further improvement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 39Kg of water for injection, add 0.25Kg of tobramycin, stir to dissolve. Take 10Kg of poloxamer (M12000-16000), sprinkle it into the above solution, let it stand overnight, then add 0.005Kg of benzalkonium chloride and 0.4Kg of sodium chloride, and stir to dissolve. Adjust the pH to 6 with boric acid, filter the solution through a 0.22 μm microporous membrane, and add water from the filter to a total of 50Kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.

Embodiment 2

[0029] Take 39Kg of water for injection, add 0.15Kg of tobramycin and 0.05Kg of dexamethasone, stir to dissolve. Take 5Kg of poloxamer (M12000-16000), sprinkle it into the above solution, let it stand overnight, then add 0.005Kg of benzalkonium bromide and 0.4Kg of sodium chloride, and stir to dissolve. Use 0.1N hydrochloric acid to adjust the pH to 5, filter the solution through a 0.22μm microporous membrane, add water from the filter to a total of 50Kg, take a sample for quality identification, and pack it into an eye drop bottle under a sterile environment after passing the test. Instantly.

Embodiment 3

[0031] Take 39Kg of water for injection, add 0.1Kg of levofloxacin hydrochloride, stir to dissolve. Take 5Kg of poloxamer (M12000-16000) and 0.4Kg of hydroxypropyl methylcellulose (E50), sprinkle it into the above solution, let it stand overnight, then add 0.015Kg of ethylparaben and 0.4Kg of glucose, stir to dissolve . Adjust the pH to 8 with 0.1N sodium hydroxide, filter the solution through a 0.22 μm microporous membrane, and add water from the filter to a total of 50Kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.

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PUM

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Abstract

An eyedrops able to become gel after it is dropped in eye for treating bacterial conjuctivities, keratitis, keratohelcosis, dacryocystitis, etc is prepared from antibacterial infilammatino-relieving medicine, thickening agent, antiseptic, isotonic regulator, pH regulator and water. Its advantages are long stay time in eye, high curative effect, and low poison and irritation.

Description

technical field [0001] The present invention relates to an eye-dropable preparation, in particular to an eye-dropable in-body gel preparation and a preparation method thereof Background technique [0002] According to statistics, 80% to 90% of outpatients in ophthalmology clinics have ophthalmology infections, and ocular inflammations are generally divided into two categories: non-infectious ophthalmia and infectious ophthalmia. Ophthalmic infections include conjunctivitis, meibomitis, meibomitis, keratitis, and global inflammation; pathogenic bacteria include bacterial infections and fungal infections. Anti-infective drugs can be used for bacterial infections, but due to the existence of the blood-ocular barrier, the concentration of drugs reaching certain tissues in the eye is limited and cannot fully penetrate. Therefore, the anti-infective drugs used in ophthalmology are those with good permeability, such as tobramycin, lincomycin, gentamicin and chloramphenicol. In re...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/16A61K31/4745A61K31/496A61K31/5383A61K31/545A61K31/7036A61P27/02
Inventor 郑梁元汪世琼刘海卫邱宁婴吴志明
Owner SHANGHAI XINGKANG PHARMA RES & DEV
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