Biodegradable medicine hydrogel and preparation method and application thereof

A biodegradable and hydrogel technology, applied in the fields of application, medical science, surgery, etc., can solve the problems that cannot meet the requirements of gelation speed and degradation time, etc., and achieve the effect of controllable performance, fast speed and broad application prospects

Active Publication Date: 2016-07-20
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, hydrogel products with a single nucleophilic or electrophilic component cannot meet the requirem...

Method used

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  • Biodegradable medicine hydrogel and preparation method and application thereof
  • Biodegradable medicine hydrogel and preparation method and application thereof
  • Biodegradable medicine hydrogel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0087] 2. Preparation and use of medical hydrogel

[0088] Method 1: a method for preparing the above-mentioned medical hydrogel by in-situ cross-linking forming hydrogel, which is realized by changing the pH value of the corresponding buffer solution.

[0089] The specific method is to dissolve the first component containing nucleophilic functional groups in buffer A with a pH of 7.5-12.5 (preferably 9.5-10.2) to obtain solution A, and dissolve the second component containing electrophilic functional groups in pH In the buffer B of 2.0-6.5 (preferably 3.9-6.0), the solution B is obtained, and then the solution A and the solution B are mixed, and the first component and the second component undergo a cross-linking reaction to form a hydrogel.

[0090]Method 2: Another method for preparing the above-mentioned medical hydrogel by in-situ cross-linking forming hydrogel is to mix the first component containing the nucleophilic functional group and the second component containing t...

Embodiment 1

[0137] Embodiment 1, prepare hydrogel with single nucleophilic component and double nucleophilic component

[0138] In order to compare the performance of hydrogels prepared with a single nucleophilic (or electrophilic) component and a double nucleophilic (or electrophilic) component, this example uses a nucleophilic component (the first component) hyperbranched polymer Ethyleneimine (PEI-1800, molecular weight 1800, structural repeating unit see Figure 7B , the primary amino group content is 35%, purchased from Aladdin Reagent Company) and trilysine (Tri-lys, purchased from Shanghai Gil Biochemical Reagent Company) as examples, compare the two alone with the electrophilic component (the second group points) Four-arm N-hydroxysuccinimide propionate-based polyethylene glycol (4-arm-PEG-SPA, molecular weight 10000), four-arm N-hydroxysuccinimide-succinate-based polyethylene glycol Diol (4-arm-PEG-SS, molecular weight 10000), four-arm N-hydroxysuccinimide glutarate-based polyeth...

Embodiment 2

[0149] Embodiment 2, changing the proportion of nucleophilic components to prepare hydrogel

[0150] The first component whose end group is a nucleophilic functional group is hyperbranched polyethyleneimine 1800 (PEI-1800, structural repeating unit see Figure 7B , molecular weight 1800, primary amino group content is 35%, purchased from Aladdin Reagent Company), and / or four-arm mercapto polyethylene glycol (4-arm-PEG-SH, molecular weight is 10000), and / or trilysine acid (Tri-lys, Shanghai Gil Biochemical Reagent Co.), and / or trilysine hydrochloride (Tri-lys-HCl), and / or two-arm aminopolyethylene glycol (2-arm-PEG-NH 2, the molecular weight is 10000), the second component whose end group is an electrophilic functional group is four-arm N-hydroxysuccinimide glutarate-based polyethylene glycol (4-arm-PEG-SG, molecular weight 10000), The ratio of the nucleophilic components was changed (see Table 2 for the formula) to prepare the hydrogel and detect its performance. The preparati...

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Abstract

The invention discloses biodegradable medicine hydrogel formed by in-situ cross linking. Gel forming time of the hydrogel is less than 20 seconds, swelling rate is 0-600%, rupture strength is not less than 50 mmHg, degradation starting time is 3-40 days, and degradation time is 7-180 days. Raw materials preparing the hydrogel include a first component containing nucleophilic functional groups and a second component containing electrophilic functional groups, and the first component and the second component are composited and physically mixed through a mixing tool and then covalently cross-linked to form the hydrogel. Physical performance and biodegradability of the hydrogel can be adjusted by changing a proportion of compositing ingredients of the first component or the second component, and the hydrogel is controllable in performance and simple to operate and can be used for organism environment at different positions.

Description

technical field [0001] The invention belongs to the field of biodegradable polymer materials, in particular to an in-situ cross-linked and biodegradable medical hydrogel and its preparation method and application. Background technique [0002] As a biocompatible material, hydrogel is mainly used in medicine for anti-adhesion after surgery, hemostatic agent, filling of defective tissue, preventing interstitial fluid leakage, and slow release of drugs. There are many types of hydrogels, such as temperature-sensitive gels, which mainly generate gels at body temperature, and at a certain temperature lower than body temperature, the gels transform into fluids; photosensitive gels, which are mainly irradiated with visible light or ultraviolet light for a short time, Cross-linking polymerizes to form a gel. [0003] Most of the hydrogels commonly used in medicine are acrylamide products, but these products mostly have monomer residues, and it is very difficult to remove the residu...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L71/08C08L79/02C08K5/20A61L24/04A61L26/00A61L31/06A61L31/14
CPCA61L24/001A61L24/0031A61L24/046A61L26/0019A61L26/0061A61L26/008A61L31/06A61L31/14A61L31/145C08J3/075C08J3/24C08K5/20C08L71/00C08L2203/02C08L2205/025C08L79/02
Inventor 董芳芳赵成如侯昭升邓凤娟李然李烨白云峰孔凡照李学刚
Owner SAIKE SAISI BIOTECH CO LTD
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