3 results about "Soft tissue engineering" patented technology

The present invention provides a photopolymerisable composition for 4D printing, comprising an acrylated polyol (AOPO) derived from a natural oil, such as olive oil, and acrylic acid as a comonomer. The composition is used in a solvent-free digital light processing (DLR) method to fabricate high-resolution, multifunctional objects. The resulting 4D printed objects are biocompatible, hemocompatible, and cytocompatible. They exhibit excellent temperature- responsive shape memory properties activated near body temperature, inherent antimicrobial activity against both gram-negative and gram-positive bacteria, and tuneable mechanical properties suitable for soft tissue engineering. Furthermore, the composition can be loaded with therapeutic agents, such as progesterone, to form biodegradable objects capable of sustained, controlled drug release. These properties make the material ideal for medical implants, cardiovascular stents, and drug delivery devices.

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where:(i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa;(ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE;(iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T;(iv) the three-dimensionally warped and branched sheet (2) has a volume VS;(v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and(vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3);(vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and / or by voids in the sheet (2); and(viii) where the conduits (5) have (a) a mean diameter DC; and (b) an anisotropicity index of 1.01 to 5.00.

The invention discloses a flexible cross-linked polyester material as well as a preparation method and application thereof, relates to the technical field of biomedical polymer materials, and overcomes the defects of the existing PPDO-PDLLA material in the aspects of flexibility, thermal responsiveness, dimensional stability and the like. The preparation method comprises the following steps: mixing PPDO-PDLLA-diol polyol with diisocyanate, and enabling excessive-NCO to react with-OH, so as to obtain a polyurethane prepolymer of which the end group is-NCO; after a chain extension reaction, polyurethane containing-NCO end groups is obtained; the preparation method comprises the following steps: reacting polyurethane containing-NCO terminal groups with an acrylate compound containing hydroxyl to obtain vinyl functionalized polyurethane, and blending and dispersing the vinyl functionalized polyurethane with PPDO-PDLLA to obtain a blend; and carrying out irradiation crosslinking on the blend to obtain the flexible crosslinked polyester material. The method can be applied to preparation of medical positioning devices, drug controlled release systems, soft tissue engineering scaffolds, flexible implants and intelligent medical materials.