40 results about "Soft tissue engineering" patented technology

The invention provides methodologies and apparatus for producing devitalized soft-tissue implants where the implant retains metabolically non-viable and / or reproductively non-viable cells, and preferably retains large molecular weight cytoplasmic proteins, such implants produced both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. A devitalized graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, optionally followed by inducing a pressure mediated flow of a salt solution, then washing the tissue to produce the devitalized graft. The devitalized grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple devitalized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the devitalized grafts produced exhibit significantly improved in long-term durability and function, and enhanced recellularization post-implantation.

The present invention relates to a fibrous scaffold for use as a substrate in soft tissue applications, in particular for preparing annulus fibrosus (AF) tissue. In aspects, the present invention also relates to an engineered biological material comprising AF tissue; constructs comprising one or more engineered biological materials; methods for producing the biological materials and constructs; and methods of using the biological materials and constructs.

The present invention is directed to a novel poly(diol citrates)-based nanocomposite materials created using completely biodegradable and biocompatible polymers that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using nanocomposites comprised of citric acid copolymers and polymers including but not limited to poly(L-lactic acid) (PLLA) and poly(lactic-co-glycolic acid) (PLGA).

Cellfree adipose tissue extracts, implants including the same and methods for the preparation thereof. The extracts and implants are capable of inducing adipogenesis and angiogenesis and are, thus, useful in applications including soft tissue repair and engineering and angiogenesis induction, e.g., in wound healing, treatment of burn injuries and ischemic conditions.

The invention belongs to the field of polymer material and biomedical engineering and in particular relates to a method for preparing temperature-sensitive amphipathic graft copolymer with chitosan asthe main chain. The method comprises the following steps: with the protection of inert gases such as nitrogen and argon, hydroxide group or aminogroup in chitosan main chain are adopted to trigger ring opening polymerization of cyclic ester monomer; then the obtained terminal hydroxide group or aminogroup of aliphatic polyester are converted to bromine group; the bromine group is taken as macroinitiator to polymerize atomic transfer radical of N-isopropyl acrylamide, hydrophilic allyl monomer, thus obtaining the needed product. The temperature-sensitive amphipathic graft copolymer with chitosan as the main chain is provided with biological degradability, biocompatibility, biological activity and temperature sensibility, can be automatically assembled into stable nano micelle in water, thus enjoying wide application in fields such as drug controlled release carrier, soft tissue engineering support material, immunoassay, memory element switch, biosensor and the like. The synthetic method of the invention is simple and feasible, the raw materials can all be applied to industrialized production, thus enjoying very good value in popularization and application.

The present invention is directed to a novel poly(diol citrates)-based nanocomposite materials created using completely biodegradable and biocompatible polymers that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using nanocomposites comprised of citric acid copolymers and polymers including but not limited to poly(L-lactic acid) (PLLA) and poly(lactic-co-glycolic acid) (PLGA).

A porous support for cartrilage tissue engineering is prepared from the high-molecular material of polyethanediol, polyamide, or polyacrylic acid type as mould material, polyhydroxy alkanoate as polymer for the porous support chloroform as solvent and water-soluble crystal as pore-forming agent through smelting the said mould material, pouring it into a container in which there is a soft silica gel male mould, obtaining a high-molecular femal mould, filling the mixture of polymer solution and pore-forming agent particles in the said femal mould, closing compacting, baking to remove solvent, dissolving the mould and pore-forming particles, and drying.

The invention relates to a hybrid hollow microcapsule, a scaffold for a soft tissue including the same, and methods of preparing the same. Disclosed is a method of preparing a hollow microcapsule using freezing of macroporous materials including a crosslinked inorganic particle network capable of elastically recovering from a highly compressed deformation state, and use of the same as a scaffold for soft tissue engineering and as a drug delivery system.

The invention discloses a non-toxic, harmless, high-mechanical-strength, high-elasticity hemicellulose foam composite material and a preparation method thereof. The method comprises the following steps: (1) adding hemicellulose and cross-linking agent into deionized water, heating and stirring until dissolved to obtain a mixed solution; (2) dissolving PVA in water, heating and stirring to dissolve to obtain a PVA solution; (3) adding The mixed solution is mixed and stirred with the PVA solution to obtain a cross-linked product, which is cooled and molded, washed and dried to obtain the non-toxic, harmless, high-mechanical-strength, and highly elastic hemicellulose foam composite material. The foam composite material is easy to process, non-toxic and harmless, has high mechanical strength and high elasticity, and has great application potential in the aspects of anti-shock and compression materials, elastic response materials, soft tissue engineering materials and biomedical materials.