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Hybrid hollow microcapsule, scaffold for soft tissue including same, and methods of preparing same

A microcapsule and hollow technology, applied in the field of soft tissue scaffold and its preparation

Inactive Publication Date: 2016-12-07
GWANGJU INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cytotoxicity based on free cross-linking agents can cause additional problems in the case of using the above substances as scaffolds for tissue engineering

Method used

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  • Hybrid hollow microcapsule, scaffold for soft tissue including same, and methods of preparing same
  • Hybrid hollow microcapsule, scaffold for soft tissue including same, and methods of preparing same
  • Hybrid hollow microcapsule, scaffold for soft tissue including same, and methods of preparing same

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preparation example Construction

[0079] Another embodiment of the present invention relates to a method for preparing hollow microcapsules. The method for preparing hollow microcapsules includes: Step (A), in ① a positively charged sacrificial core material or ② modified into a negatively charged sacrificial core material Forming a core polymer layer on the core material; step (B), ① in the case that the above-mentioned sacrificial core material is a positively charged sacrificial core material, alternately forming inorganic nanoparticle layers and capsules on the above-mentioned core polymer layer more than once The polymer layer for coating, ② In the case where the above-mentioned sacrificial core material is a sacrificial core material modified to be negatively charged, the above-mentioned core polymer layer is alternately formed on the above-mentioned core polymer layer for one or more times to coat the inorganic nanoparticle coating combination Inorganic nanoparticle layer and polymer layer for capsule co...

Embodiment 1

[0090] Example 1: Hydroxyphosphorus crosslinked by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide crosslinker Preparation and Characterization of Stone / Gel Scaffolds (Hydroxyapatite Nanoparticles Covered with Citrate@1-Ethyl-3-(3-Dimethyl Aminopropyl) carbodiimide-crosslinked gum )

[0091] Soft and elastically recoverable macroporous hydroxyapatite nanoparticles were cross-linked at -18°C by crosslinking citrate-coated and glue-coated (type B glue from porcine) hydroxyapatite nanoparticles Limestone / Gum Brackets. In the final solution before being frozen, the weight percent of polymer to particle was maintained at 1:10. That is, in 0.6 ml of deionized water, 6 mg of glue is applied to 60 mg of particles, and the amount of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide is set to 0.1 mg , 0.5mg, 2mg and 4mg (refer to figure 2 a to figure 2 d’s scanning electron micrograph). figure 1 a is a digital image of a 4 mg 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide scaffol...

Embodiment 2

[0100] Example 2: Preparation of carbon dioxide crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide crosslinking agent Silicone / gel scaffold (silica @ 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cross-linked glue )

[0101] 10% by weight of silica nanoparticles with a size of 500 nm were vortexed in the e-tube and coated with 1% glue. The final volume of the solution was 0.6 ml, and the amounts of particles and polymers were 60 mg and 6 mg, respectively. 4 mg of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide crosslinker was added to the final solution, and the crosslinking was completed by freezing at -18°C for 24 hours. The mechanical properties of the obtained scaffold are similar to the hydroxyapatite 10% / glue 1% / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide 4mg scaffold of Example 1 ( figure 2 f). The walls of the stent are mainly composed of silica particles.

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Abstract

The invention relates to a hybrid hollow microcapsule, a scaffold for a soft tissue including the same, and methods of preparing the same. Disclosed is a method of preparing a hollow microcapsule using freezing of macroporous materials including a crosslinked inorganic particle network capable of elastically recovering from a highly compressed deformation state, and use of the same as a scaffold for soft tissue engineering and as a drug delivery system.

Description

technical field [0001] The present invention relates to mixed hollow microcapsules, a scaffold for soft tissue containing the same and a preparation method thereof. Background technique [0002] In the field of tissue engineering, in order to obtain the desired biological effects, macroporous biocompatible substances are used as templates for cell growth and transplantation into animal models. For histoengineering applications, the similarity of the mechanical properties of the template to the host tissue is extremely important. Also, mechanical stimulation from corresponding substances modulates the differentiation response of stem cells. [0003] For tissue engineering applications of soft tissues such as adipose tissues, soft and elastically recoverable scaffolds such as corresponding host tissues are required. For example, the modulus of elasticity of adipose tissue ranges from 3 to 4 kPa. After implanting the corresponding substance, when an external force is applied...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/30A61L27/32A61L27/40A61L27/50A61L27/56A61F2/28C08J3/24
CPCA61F2/28A61L27/306A61L27/32A61L27/34A61L27/40A61L27/50A61L27/56C08J3/246A61L27/54A61L2430/34A61L2420/02A61L2420/04C08L5/08C08L5/04B01J13/14B01J13/203B01J13/22A61K9/5115A61K9/5161A61L27/12A61L27/222A61L27/18A61L27/20A61K9/4891A61K9/485A61K9/4866A61K9/4808A61L27/025
Inventor 太琪戎R·拉扎马尼克卡姆金钟彻
Owner GWANGJU INST OF SCI & TECH
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