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Preparation method of high strength hydrogel with simulated insect cuticle structure

A high-strength, hydrogel technology, applied in the field of biomass materials, can solve the problems of poor bearing capacity and insufficient mechanical properties of gum-based hydrogels, improve efficiency, increase added value, and solve poor mechanical properties and bearing capacity Effect

Active Publication Date: 2019-06-18
NANJING FORESTRY UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The object of the present invention is to design a method for preparing a high-strength hydrogel imitating the structure of insect skin based on the sclerosis reaction of insect skin and imitating the biological structure of insect skin nanofiber skeleton to solve the problem of gelatin-based hydrogel bearing capacity Poor, insufficient mechanical properties

Method used

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  • Preparation method of high strength hydrogel with simulated insect cuticle structure
  • Preparation method of high strength hydrogel with simulated insect cuticle structure
  • Preparation method of high strength hydrogel with simulated insect cuticle structure

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preparation example Construction

[0031] The following are the specific steps of the preparation method of the high-strength hydrogel imitating the insect skin structure of the present invention:

[0032] 1) Put 10-20g of chitin powder (from discarded shrimp and crab shells) in 500-800ml, 30 wt%-35 wt% NaOH solution, mechanically stir at 80-90°C for 2-4 hours, the chitin Partially deacetylated. Through vacuum filtration, the obtained partial chitosan was fully washed until neutral.

[0033] 2) Dilute the above partially chitosan to 0.8-1wt% with 1 wt% acetic acid solution, and grind with a grinder to prepare a suspension of partially chitosan nanofibers. The grinding conditions are as follows: the rotational speed of the grinder is 1500 rpm / min, and the gap between the grinding discs is 0.25-0.35 mm.

[0034] 3) Dilute the suspension of the above-mentioned partial deacetylated chitin nanofibers to 0.3-0.5 wt % with distilled water, ultrasonically treat for 2-5 minutes, and then place the polytetrafluoroethyl...

Embodiment 1

[0039]1) Put 20g of chitin powder in 800ml, 33 wt% NaOH solution, and mechanically stir at 90°C for 4 hours to partially deacetylate chitin. The degree of deacetylation of chitin after elemental analysis is 40%. Through vacuum filtration, the obtained part of the chitosan sample was fully washed until neutral.

[0040] 2) Dilute the above partially chitosan to 0.8 wt% with 1 wt% acetic acid solution, and grind it through a grinder to prepare a suspension of partially chitosan nanofibers. The grinding conditions are as follows: the rotational speed of the grinder is 1500 rpm / min, and the gap between the grinding discs is 0.3 mm.

[0041] 3) Dilute the above part of chitosan nanofiber suspension to 0.5 wt % with distilled water, ultrasonic treatment for 2 minutes, then place the polytetrafluoroethylene membrane with a pore size of 0.1 micron in the sand core funnel of the vacuum filter, pass through The suspension was dehydrated by vacuum filtration to prepare a wet film of pa...

Embodiment 2

[0046] 1) Put 10g of chitin powder in 500ml of 30 wt% NaOH solution, and mechanically stir for 4 hours at 80°C to partially deacetylate chitin. The deacetylation degree of chitin obtained after elemental analysis is 30%. Through vacuum filtration, the obtained part of the chitosan sample was fully washed until neutral.

[0047] 2) Dilute the above partially deacetylated chitin to 1 wt% with acetic acid solution with a concentration of 1 wt%, and grind it through a grinder to prepare a suspension of partially chitin nanofibers. The grinding conditions are as follows: the rotational speed of the grinder is 1500 rpm / min, and the gap between the grinding discs is 0.35 mm.

[0048] 3) Dilute the above part of the chitosan nanofiber suspension to 0.3 wt % with distilled water, ultrasonicate for 5 minutes, then place the polytetrafluoroethylene membrane with a pore size of 0.1 micron in the sand core funnel of the vacuum filter, pass through The suspension was dehydrated by vacuum ...

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Abstract

The invention belongs to the field of biomass materials, and relates to a preparation method of a high strength hydrogel with a simulated insect cuticle structure. The preparation method comprises following steps: (1) subjecting chitin to a partial deacetylation treatment; (2) diluting the product obtained in the step (1) by an acetic acid solution, and then grinding the product; (3) diluting theproduct obtained in the step (2) by distilled water, carrying out an ultrasonic treatment, filtering the solution in vacuum, and carrying out film forming; (4) fully impregnating the product obtainedin the step (3) in a gelatin solution; and (5) impregnating the product obtained in the step (4) into a quinone crosslinking reaction solution, and making the product carry out quinone crosslinking reactions at a room temperature to obtain partially de-acetylated chitin nano fiber / gelatin composite gel. The operation of the method is simple and rapid; and moreover, the prepared composite hydrogelhas excellent mechanical properties and has a great application value in fields such as artificial skin, biosensors, soft tissue engineering materials, and the like.

Description

technical field [0001] The present invention relates to a preparation method of a high-strength hydrogel imitating the structure of insect epidermis, specifically a synthesis mechanism and structural characteristics of insect epidermis, and construction of high-strength partially deacetylated chitin nanofiber / gelatin composite gel The preparation method belongs to the field of biomass materials. Background technique [0002] Biological tissue engineering materials, such as cartilage and ligaments, cannot spontaneously regenerate in vivo once injured. Parts such as tendons and ligaments have load-bearing capacity, and are easily broken or torn due to external mechanical forces. Hydrogel is a three-dimensional polymer network structure that absorbs water, locks water and is insoluble in water, and can provide a highly hydrated environment similar to natural tissues. Therefore, synthetic hydrogels based on biomass substrates are often used as effective substitutes after soft ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08J5/18C08J7/00C08L5/08C08L89/00
Inventor 陈楚楚刘育绮罗德丹冯前孟陶陶邹同张叶李大纲
Owner NANJING FORESTRY UNIV
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