Soft tissue engineering scaffold and preparation process thereof

A tissue engineering scaffold and film technology, applied in medical science, muscle, ligament and other directions, can solve the problems of poor controllability, complex, difficult to build structures, etc. Effect

Inactive Publication Date: 2010-11-10
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these processes have poor controllability, and it is difficult to construct a scaffold microstructure with complex structur

Method used

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  • Soft tissue engineering scaffold and preparation process thereof
  • Soft tissue engineering scaffold and preparation process thereof
  • Soft tissue engineering scaffold and preparation process thereof

Examples

Experimental program
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Embodiment Construction

[0022] A soft tissue engineering scaffold, the visceral soft tissue engineering scaffold is formed by crimping or stacking small balls and thin films.

[0023] The pellets are made of biological materials (such as chitosan, silk fibroin, collagen, hydrogel, polylactic acid or polylactic acid-polyglycolic acid, heparin, cells, growth factors, and other anticoagulants), and can also be made of These biomaterials are mixed with cells; the pellets can be made by hand or pressed through molds;

[0024] The film is composed of biological materials (such as silk fibroin, chitosan, collagen, hydrogel, polylactic acid or polylactic acid-polyglycolic acid, heparin, and other anticoagulants), and can also be formed from these biological materials. Mix with cells and growth factors by infiltration. The material of the film must have a certain degree of elasticity and toughness, which is convenient for forming and maintaining the shape of the stent.

[0025] There are two types of films:...

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Abstract

The invention discloses a soft tissue engineering scaffold and a preparation process thereof. Millimeter-grade pellets and films are combined together to form a cell scaffold by a curling process or superimposing process. The pellets and the films can be made from different biological materials so as to fully play different roles of both the pellets and the films, wherein the films are made from an elastic biological material and used for accommodating the pellets; the elastic biological material is provided with a millimeter-grade pit structure of which the size and the shape correspond to those of the pellets; and the pellets are made from a material which has high biocompatibility. In order to increase the conduction, pores are formed on the pellets, contact points between the films and the pellets and areas among pits. The pellets and the films can be independently compounded with cells to form a cell scaffold compounded body respectively, then the pellets are placed into the pitsformed on the films one by one, and finally the films are curled or superimposed layer by layer. A large number of pellets are clamped among the films, and the compounded body can be directly implanted into a body and can also be used for culture in vitro.

Description

technical field [0001] The invention relates to a soft tissue engineering bracket and its manufacturing process, in particular to a bracket made of small balls and films rolled or stacked together and a forming method thereof. Background technique [0002] Visceral soft tissue transplantation such as liver, pancreas, and kidney is an effective means to treat various chronic soft tissue diseases, but the shortage of donors has always restricted soft tissue transplantation. Tissue engineering provides the possibility to cultivate living soft tissues in vitro, and it is expected to realize the engineered manufacture of soft tissues such as internal organs. However, soft tissue engineering has specific requirements for the stent structure: in addition to a large number of internal pipelines in the stent, the stent is also required to be soft and flexible to avoid damage to internal organs. In addition, it is best to choose materials such as extracellular matrix for the scaffold...

Claims

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Application Information

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IPC IPC(8): A61F2/08A61L27/24A61L27/22A61L27/20A61L27/18A61L27/14A61L27/38
Inventor 刘亚雄赵倩李涤尘连芩高琨卢秉恒
Owner XI AN JIAOTONG UNIV
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