29 results about "Nicotinuric acid" patented technology

The invention discloses a phagostimulant capable of improving the prevention and control effect of cotton flower thrips and application of the phagostimulant. The phagostimulant is prepared from the following components in parts by weight: 10 to 30 parts of p-methoxycinnamyl aldehyde, 5 to 40 parts of anisaldehyde, 40 to 70 parts of ethyl nicotinate and 10 parts of a cosolvent. The phagostimulant is prepared from the following components in parts by weight: 10 to 30 parts of p-methoxycinnamyl aldehyde, 5 to 40 parts of anisaldehyde, 40 to 70 parts of ethyl nicotinate and 10 parts of cosolvent. By utilizing the tropism of the cotton flower thrips to specific volatile compounds and through the synergistic effect of the three plant source compounds, pests hidden in stamens, petal wrinkles, leaf backs and other hidden parts are attracted to a pesticide application area, the contact area of insect bodies and the pesticide is remarkably increased, and therefore the prevention and control effect is improved. Field tests show that when an optimal formula (the ratio of p-methoxycinnamaldehyde to anisaldehyde to ethyl nicotinate to the cosolvent is 20: 20: 50: 10) is matched with spinetoram for use, the control effect can reach 84.43%-92.22%, the control effect is remarkably improved compared with that of single use of an insecticide, and a good control effect is shown. The method is safe and environment-friendly, reduces the amount and increases the efficiency, and has remarkable economic and ecological benefits.

This invention discloses a highly efficient catalytic synthesis process for nicotinamide intermediates using the field of organic synthesis technology. The process includes: adding appropriate amounts of dichloronicotinic acid, organic solvent, lanthanum-doped composite metal fluoride-diatomaceous earth supported catalyst, and encapsulated 4A molecular sieve to a reaction vessel under nitrogen protection; purging with nitrogen, heating, and stirring; introducing anhydrous dimethylamine gas, controlling the pressure, and continuing stirring; after the reaction is complete, washing with sodium bicarbonate aqueous solution, washing with deionized water, drying, concentrating, and recrystallizing to obtain the target product. The lanthanum-doped composite metal fluoride-diatomaceous earth supported catalyst prepared by this invention is recyclable, has mild reaction conditions, high product yield, is environmentally friendly, and suitable for industrial production.

The present disclosure provides antibodies and polypeptides that specifically bind to nicotinic acid phosphoribosyltransferase (NAPRT). Also provided are nucleic acids encoding the antibodies, expression vectors and host cells for making the antibodies, methods of using the antibodies to detect NAPRT in a sample from a subject in need thereof, methods of using the antibodies to diagnose a subject having cancer or sepsis. Compositions comprising these antibodies are also provided. Also provided are compositions comprising a nicotinamide phosphoribosyltransferase inhibitor (NAMPTi), and methods of using the NAMPTi to treat cancer following diagnosis with the NAPRT antibody.

The invention relates to the field of pesticide synthesis, in particular to a synthesis method of ethonicotinic acid. 5-ethyl pyridine-2. 3-dicarboxylic acid diethyl ester and 2-amino-2. 3-dimethyl butyramide are used as raw materials and react in a sodium ethoxide ethanol solution at the temperature of 50-70 DEG C, hydrogen chloride gas is introduced into a system for acidification after the reaction is completed, and imazethapyr and a by-product sodium chloride are obtained. The hydrogen chloride gas is directly introduced in the acidification process, and the acidification process is free of hydration, so that on one hand, no direct wastewater is generated, the generation of wastewater with high salt content and high organic matter content is avoided, the treatment cost is reduced, on the other hand, the byproduct sodium chloride is firstly removed from the system by controlling the ethanol amount of the system, and then concentration and crystallization are performed; the high-purity imazethapyr of which the purity is greater than 99% is obtained by utilizing the solubility of the solvent ethanol to impurities, and the quality of both byproducts and main products is at a higher level in the industry.

The application provides a preparation method of a medical intermediate 4-bromo-6-chloronicotinic acid methyl ester. The method takes 4,6-dichloronicotinic acid methyl ester as a starting material, reacts with an alkali salt to obtain 6-chloro-4-hydroxynicotinic acid methyl ester; then the 6-chloro-4-hydroxynicotinic acid methyl ester reacts with a bromination reagent under the action of an acid binding agent to obtain the target product 4-bromo-6-chloronicotinic acid methyl ester. The preparation method has short steps, the raw material is easy to obtain and low in price, the reaction conditions are mild, easy to purify, and simple to operate; meanwhile, the product has high yield, high purity, low production cost, is convenient for industrialized production, has a good application prospect, and plays a positive role in the research and development of downstream products of 4-bromo-6-chloronicotinic acid methyl ester.

This invention discloses a 2-hydroxynicotinic acid-2-hydroxybenzyl ester, its preparation method, and its application. The structural formula of the 2-hydroxynicotinic acid-2-hydroxybenzyl ester is shown below. This invention utilizes 2-hydroxynicotinic acid as a raw material and obtains a 2-hydroxynicotinic acid-2-hydroxybenzyl ester with a novel structure through esterification. The 2-hydroxynicotinic acid-2-hydroxybenzyl ester has low cytotoxicity, can scavenge reactive oxygen species, and has good anti-UVB-induced oxidative damage activity in HaCaT cells. It can be used in products for anti-skin oxidative damage.

The present application relates to the technical field of oral liquid, in particular to a kind of oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow and preparation method thereof, it is characterized in that, the oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow is made of the following components, by weight parts: artemisia capillaris 200~300 parts, gardenia 150~200 parts, bupleurum 100~150 parts, polygonatum 50~100 parts, radix paeoniae alba 50~100 parts, liquorice 10~50 parts, nicotinic acid 1~10 parts, propylene glycol 200~300 parts, fructose diphosphate sodium 1~10 parts, pure water 200~400 parts.The oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow can prevent and treat ketosis, fatty liver and liver damage at the same time, comprehensively improve the constitution of new cow, improve immunity, improve physical indicators and reproductive performance, increase economic benefits.

The subject of the application is a tool for applying methyl nicotinate solution, which is characterized in that it consists of a base (1) in the shape of a cuboid. The lower surface of the base (1) has a T-shaped recess along its entire length, in which at least two T-shaped mounting brackets (2) are press-fitted. Square frames (3) are attached to the lower surfaces of the mounting brackets (2). Sponges (4) are press-fitted into the frames (3). A digital timer (5) is attached to the upper surface of the base (1) by gluing.

The present invention aims to provide an oral composition that has an astringent sensation while effectively suppressing discoloration over time. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, (B) component: fluorine-containing compound, and (C) component: an anionic surfactant, wherein the content of component (B) is such that when converted to a fluoride ion concentration it is 1000 to 4000 ppm, and the content of component (C) is such that it is 0.05 to 5% by mass, preferably further comprising (D) component: at least one selected from the group consisting of saccharin sodium, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol, and more preferably further comprising (E) component: at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

The invention relates to a composition with an eye enlarging effect and application of the composition. The composition is prepared from soluble collagen, tocopheryl nicotinate, acetyl hexapeptide-8, hydrolyzed rice protein, acetyl tetrapeptide-5, Arabic gum, rhizobium gum, an arnica extract and schizophyllum commune fermentation product filtrate. By compounding a plurality of plant extracts and polypeptides for use, excellent effects of tightening, lifting, removing pouches and reducing melanin can be realized, and the eye cream has a visual eye enlarging effect and is more young.

The present disclosure relates to a non-therapeutic use of a human milk oligosaccharide (HMO) selected from 3'-sialyllacto-N-tetraose (LSTa), 6'-sialyllacto-N-neotetraose (LSTc) and 3'-sialyl- 3-fucosyllactose (FSL), or a combination thereof, in supporting or improving one or more of brain health, immune system health, gut health, and metabolic health, in a subject, optionally by increasing the production of one or more metabolites selected from the group consisting of of pyridoxine, pyridoxamine, nicotinic acid, N-acetyl-L-glycine, sarcosine, N-acetyl-L-glutamine, N- acetyl-L-aspartic acid, trigonelline, trans-4-hydroxyproline, 3-hydroxybutyric acid (BHB), 4- hydroxybenzoic acid, and N-acetyl-L-tryptophan, in the gastrointestinal tract of the subject.

The invention discloses application of methyl nicotinate as a marker in evaluation of bull semen quality, and belongs to the technical field of animal reproduction and metabonomics. The relative content of methyl nicotinate in the bull rumen fluid with high semen quality is significantly higher than the relative content of methyl nicotinate in the bull rumen fluid with low semen quality. By detecting the relative content, the bull semen quality is evaluated, the reproductive performance can be reliably judged on the premise of not depending on a semen sample, and the method has the remarkable advantages of being non-invasive, high in throughput, capable of advancing a prediction window and the like.

The invention discloses a nicotinoyl metformin crystal form and a preparation method thereof. According to the nicotinoyl metformin crystal form shown in the formula I provided by the invention, in an X-ray powder diffraction pattern, at least three characteristic peaks exist at the diffraction angles of 10.64 + / -0.2 degrees, 11.42 + / -0.2 degrees, 15.18 + / -0.2 degrees, 16.06 + / -0.2 degrees, 16.44 + / -0.2 degrees and 25.22 + / -0.2 degrees, which are represented by 2 theta. The invention also provides a preparation method, which comprises the following steps: 1) dissolving metformin hydrochloride and ethyl nicotinate in an organic solvent in an inert gas atmosphere to form a solution 1; dissolving an organic metal strong base catalyst in an organic solvent to form a solution 2; and 2) dropwise adding the solution 2 into the solution 1 while stirring, reacting, pouring the reacted solution into ice water after the reaction is finished, filtering, washing, and drying to obtain the nicotinoyl metformin crystal form. The crystal form parameters of the nicotinoyl metformin are obtained for the first time, and the nicotinoyl metformin has high purity, high stability and low hygroscopicity; the preparation method can directly obtain the nicotinoyl metformin crystal form, and is simple, high in yield, simple in post-treatment and efficient in preparation.

The present invention provides methods of preparing compound of Formula (I), wherein the compounds are represented by the structure of Formula (I) wherein: R1 each is independently F, Cl, Br, I, OCH3, CN or NO2; R2 each is independently identical or different C1-C5 alkyl; n1 is an integer between 1 and 5; and n2 is an integer between 1 and 4. In addition, the present invention provides a compound represented by the following structures: Compound (1a) and Compound (2), wherein X comprises: chloride, acetate, adipate, alginate, ascorbate, aspartate, benzoate, benzenesulfonate, bisulfate, borate, butyrate, citrate, camphorate, camphorsulfonate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, hydroiodide, maleate, 2-hydroxyethanesulfonate, lactate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oxalate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, salicylate, succinate, sulfate, sulfonate, tartrate, thiocyanate, toluenesulfonate, or undecanoate salt, or any combination thereof.

The invention belongs to genetic engineering modification, and particularly relates to recombinant lactobacillus plantarum with high yield of nicotinamide mononucleotide as well as a construction method and application thereof. The recombinant lactobacillus plantarum is obtained by overexpressing lactobacillus plantarum endogenous nicotinic acid ribosyl phosphate transferase genes pncB1 and / or pncB2 in a host strain. According to the invention, a strain capable of efficiently synthesizing the NMN is constructed by taking the lactobacillus plantarum as a chassis for the first time, and an endogenous NMN synthesis path is directly enhanced by specifically expressing endogenous nicotinic acid phosphoribosyltransferase pncB1 and pncB2, so that the yield of the lactobacillus plantarum NMN is greatly increased. The lactobacillus plantarum endogenous nicotinic acid phosphoribosyltransferase is modified by adopting a genetic engineering technology, so that the problems of weak exogenous gene expression capability and substrate absorption and transformation are successfully solved, and a feasible solution is provided for production of other probiotics NMN.

This invention provides a method and apparatus for continuous flow synthesis of the key intermediate MMPE, etocoxib. The method includes the following steps: First, a 4-methanesulfonylphenylacetic acid solution and a first stream of tert-butylmagnesium chloride solution are subjected to a first-step continuous flow synthesis to obtain reaction solution A; then, reaction solution A and a methyl 6-methylnicotinate solution are subjected to a second-step continuous flow synthesis to obtain reaction solution B; next, reaction solution B and a second stream of tert-butylmagnesium chloride solution are combined to obtain the final reaction solution C; the obtained reaction solution C is post-processed to obtain the desired MMPE product. A microreactor is selected as the reactor for the reaction. The method provided by this invention significantly simplifies the preparation process, greatly shortens the reaction time, and achieves excellent yield and purity, while also exhibiting excellent reproducibility.

The present disclosure relates to multi-enzyme pathways for the in-situ generation of the cofactor NADP from cost-effective reagents such as nicotinate, NMN (nicotinamide mononucleotide) and NAD (nicotinamide adenine dinucleotide) and the use of these pathways in NADP-dependent cell-free systems for the bio-based production of chemicals such as isobutanol.

The invention belongs to the technical field of biological polypeptide research, and particularly relates to application of polypeptide in increasing the content of collagen, fibroblast and fibrillar protein. The polypeptide is a Taiwan mitochondrial energy sphere peptide, and the sequence of the polypeptide is nicotinic acid-C-C-C-A-r-B-r-B-r-B-r-A-R-G-D-A-NH2, and the sequence of the Taiwan mitochondrial energy Wherein G is glycine, R and r are arginine, D is aspartic acid, A is tyrosine, B is tryptophan, C is phenylalanine, in the polypeptide, r is D configuration, and other amino acids are L configuration. The Thai mitochondrial energy sphere peptide disclosed by the invention can remarkably improve the contents of various collagens and the contents of elastin and fibrillar protein, so that the Thai mitochondrial energy sphere peptide has a wide application prospect in the aspects of aging resistance and oxidation resistance.

The main purpose of the present inventors is to provide a technique for suppressing inflammation, in particular, in aging tissues within the oral cavity.　The present inventors have found that an oral composition containing at least one selected from the group consisting of β-glycyrrhetinic acid, glycyrrhizic acid, ascorbic acid, tocopherol nicotinate, tocopherol acetate, pyridoxine, cobalamin, retinol, retinol acetate, riboflavin, phylloquinone, calciferol, anthraquinone, menaquinone-4, and L-aspartic acid, and chemically acceptable salts thereof, quercetin, genistein, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof, and methyl hesperidin can suppress inflammation, in particular, in aging tissues within the oral cavity.

The invention relates to the technical field of organic synthesis, in particular to a 2-(styryl) tetrahydrofuran compound and a preparation method thereof, and the structure of the compound is shown as a general formula (I). The method comprises the following steps: under the protection of an inert atmosphere, reacting tetrahydrofuran, aryl alkyne as shown in a general formula Ar-C = CH, methyl isonicotinate, pinacol borate and alkyl N-hydroxyphthalimide ether under a heating condition, and separating and purifying after the reaction is completed, so as to obtain the compound as shown in the general formula (I). A pyridine-boron free radical is used as a catalyst to induce alkyl N-hydroxyphthalimide ether to be reduced to generate an oxygen free radical, the oxygen free radical is used as an HAT reagent to grab H, then activation of a C-H bond is achieved, and then the two components are coupled to obtain a target product. The method does not need metal participation, the reaction condition is mild, and the substrate range is wide; the method can be used as an ideal alternative way for synthesizing the 2-(styryl) tetrahydrofuran compound.

The invention relates to the technical field of chemical synthesis, and discloses a preparation method and application of a pyrimidine derivative. The preparation method of the pyrimidine derivative comprises the following steps: in a solvent I, contacting a polychloro-substituted pyrimidine compound, a cyanate compound and a phase transfer catalyst, and carrying out a reaction I to obtain the pyrimidine derivative, according to the application of the pyrimidine derivative, boscalid is synthesized by adopting the prepared pyrimidine derivative as a catalyst, 2-chloronicotinic acid can directly react with parachloroaminobiphenyl to generate boscalid, and the acyl chloride synthesis step is omitted.

The application provides a fermented Lactobacillus muci-dei capable of accelerating alcohol metabolism and improving hangover state and an application thereof.The strain has high safety, does not contain resistance genes and pathogenic virulence genes, and has strong tolerance to bile salts, artificial gastric juice and artificial intestinal juice.The strain has strong antioxidant capacity and has strong scavenging capacity for ABTS, DPPH and hydroxyl radicals.The fermented Lactobacillus muci-dei can improve the content of ethanol dehydrogenase of an alcoholic liver disease model mouse, and has significant application value in terms of antioxidant, alcohol elimination and hangover prevention.Meanwhile, the strain can produce melatonin and can convert NR into nicotinic acid.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of isoindolone. N-methylbenzylamine derivative as shown in formula 1, N-methyl-N-(4-pyridylmethyl) amine as shown in formula 4, N-methyl-2-thiophenemethylamine as shown in formula 6, 2-methoxy methyl benzoate derivative as shown in formula 2 and 2-methoxy methyl nicotinate pyridine as shown in formula 9 in bis (trimethylsilyl) The method comprises the following steps of: mixing and reacting with an organic solvent methyl tert-butyl ether in the presence of a catalyst, lithium amide and a cesium fluoride additive to synthesize isoindolone as shown in a formula 3, isoindolone as shown in a formula 5, isoindolone as shown in a formula 7 and isoindolone as shown in a formula 10.

Autoimmunity and (Chronic) To provide isolated monoclonal antibodies that bind to human CD38 and are useful in the treatment of diseases including inflammatory diseases such as type 1 and type 2 diabetics, thyroiditis, Graves' disease, arthritides, neuroinflammation and asthmatics.SOLUTION: There are provided antibodies binding to human CD38 in which Asp at a specific position of an amino acid sequence is substituted with Gly.EFFECT: Antibodies that bind to human CD38 are those that do not bind to the human CD38 mutant to the same extent that they bind to wild-type human CD38, and have a strong stimulatory effect on the cADPR hydrolase activity of CD38, leading to reduced levels of cADPR and inhibiting the capability of CD38 to catalyse the formation of nicotinic acid adenine dinucleotide 2 ' - phosphate (NAADP) via a base exchange reaction.SELECTED DRAWING: None

The invention belongs to the field of organic synthesis and pesticide application, and particularly relates to application of a novel isoindolone substance, the structural formula is as follows: R1 is hydrogen, 3-methyl, 4-methyl, 4-methoxyl, 3-methoxyl or 2-methoxyl chloride; meanwhile, the N-methylbenzylamine can also be changed into N-methyl-N-(4-picolyl) amine (2) and N-methyl-2-thiophenemethylamine (3). Wherein R2 is selected from hydrogen, 3-methyl, 4-methyl, 5-methyl, 6-methyl, 3-methoxyl, 4-methoxyl, 5-methoxyl, 6-methoxyl, fluorine and chlorine; meanwhile, the 2-methoxy methyl benzoate can also be changed into the 2-methoxy methyl nicotinate pyridine (4). A biological activity determination result shows that the isoindolone compound containing the thiophene and methyl structure has medium to excellent inhibitory activity on phytophthora capsici, the activity of the compound A31 is the best, the inhibitory activity on the phytophthora capsici is 95 + / -3% and is equivalent to that of a control drug metalaxyl, and EC50 is equal to 1.3048 mu g / mL and is superior to that of the control drug metalaxyl.

This invention discloses a four-step method for preparing 4-trifluoromethylnicotinic acid from 2-chloroacrylonitrile, belonging to the field of chemical pharmaceutical intermediate synthesis. Using 2-chloroacrylonitrile as a raw material, an amination reagent is added to prepare 3-amino-2-chloropropionitrile, which is then reacted with 4-ethoxy-1,1,1-trifluorobut-3-en-2-one to prepare 2-chloro-3-((4,4,4-trifluoro-3-oxobut-1-en-1-yl)amino)propionitrile. Finally, a two-step method involving cyclization and hydrolysis with the addition of an alkali yields the target product 4-trifluoromethylnicotinic acid. This method yields a product with high purity and high yield, low raw material cost, a short and efficient route, mild reaction conditions, and is environmentally friendly, making it more suitable for industrial production.

The preparation method comprises the following steps: adding deionized water, pearl powder, a humectant, essence, gypenoside, caprolactam-based silicone oil, trehalose, propylene glycol, nicotinic acid amine and sucrose stearate into a stirring device, and stirring to obtain a mixed solution, namely the whitening and moisturizing essence. Then adding a thickening agent while stirring, spraying the thickening agent into the mixed solution to fully dissolve the thickening agent, introducing the dissolved mixed solution into a filtering device through a feeding pipe, enabling the mixed solution to fall onto a filter screen, enabling the mixed solution filtered by the filter screen to flow out through a flow guide hole, enabling the mixed solution flowing out to enter a reaction kettle through a flow guide pipe, and continuously reacting to obtain a solution; and adding the perfume rose extract, the preservative and the vitamin E into the solution in the step 2, and stirring to obtain the essence with the whitening and moisturizing functions.