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Formula food with special medical application and preparation method thereof

A medical food and application technology, applied in the field of biochemistry, can solve the problems of difficulty in the industrial production of milk-derived bioactive peptides, low initial whey protein concentration, and low yield of active peptides, and reduce the possibility of human immune rejection Sexuality, easy absorption by the body, and simple operation

Active Publication Date: 2016-04-13
中健医用食品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all the above methods still have defects such as cumbersome operation, low initial whey protein concentration, low yield of active peptides, and high cost.
The industrial production of milk-derived bioactive peptides is still difficult

Method used

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  • Formula food with special medical application and preparation method thereof
  • Formula food with special medical application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Weigh 50g of whey protein, hydrate it, and prepare it into a whey protein suspension of 1.0wt%, and add folic acid and five thousandths of the whey protein amount to the whey protein suspension. For niacin, add trypsin and papain (composed according to the weight ratio of 2:1) with a mass of 0.1% of the whey protein amount to the whey protein suspension. Under constant temperature conditions of 45°C, a completely transparent solution was obtained after enzymatic hydrolysis in a constant temperature enzymatic hydrolysis tank for 1 hour. After testing, the degree of hydrolysis of whey protein was 36.5%, and then the whey protease hydrolyzate in the reaction system was heated rapidly to 100° C. and kept for 20 minutes to inactivate the enzyme. The degree of hydrolysis is controlled, and then the obtained whey protein peptide solution is concentrated, spray-dried, and the inlet air temperature is controlled at 190°C, the outlet air temperature is 95°C, and the feed flow rat...

Embodiment 2

[0048] Weigh 50g of whey protein, hydrate it, and prepare 5.0wt% whey protein suspension, add folic acid and 3 / 1000th of the whey protein amount to the whey protein suspension Niacin, add 0.2% of whey protein Bioprase SP-20 and papain (composed of according to the weight ratio of 3:1) to the whey protein suspension, under 40 ℃ of constant temperature conditions, in the constant temperature enzymolysis tank After hydrolysis for 6 hours, a completely transparent solution was obtained. After testing, the degree of hydrolysis of whey protein is 41.2%, and then the reaction system whey protease hydrolyzate is rapidly heated to 100°C and kept for 20 minutes to inactivate the enzyme and control the degree of hydrolysis, and then concentrate the obtained whey protein peptide solution , Spray drying, controlling the inlet air temperature to 190°C, the outlet air temperature to 95°C, and the feed flow rate to 20ml / min to obtain powdered compound whey protein peptide products. After tes...

Embodiment 3

[0050] Weigh 50g of whey protein, hydrate, and prepare 20.0wt% whey protein suspension, add folic acid and 1 / 1000th of the whey protein amount of folic acid and 1 / 1000th of the whey protein suspension acid, add Bioprase SP-20 with 0.5% whey protein amount and papain (composed of according to the weight ratio of 1:1) to the whey protein suspension, under the constant temperature condition of 50 ℃, enzymatic hydrolysis in the constant temperature enzymolysis tank for 8h A completely transparent solution was obtained. After testing, the degree of hydrolysis of whey protein is 47.3%, and then the reaction system whey protease hydrolyzate solution is rapidly heated to 100°C and kept for 20 minutes to inactivate the enzyme and control the degree of hydrolysis, and then concentrate the obtained whey protein peptide solution , Spray drying, controlling the inlet air temperature to 190°C, the outlet air temperature to 95°C, and the feed flow rate to 10ml / min to obtain a powdered comple...

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Abstract

The invention provides a formula food with special medical application and a preparation method thereof, and application of the formula food in preparation of a medical drug. The prepared lactalbumin small peptide contains folic acid accounting for one millionth to one ten thousandth of the lactalbumin peptide by mass and nicotinic acid accounting for one thousandth to five thousandths of the lactalbumin peptide by mass; the lactalbumin peptide with molecular weight smaller than 1000 Dalton accounts for more than or equal to 98%. The product has the characteristics of high activity, high absorption rate, high nutrition, high safety and no side effect. By adopting the method, the lactalbumin is subjected to sufficient enzymolysis, the lactalbumin peptide yield is high, the prepared lactalbumin pepetide is a polypeptide mixture consisting of 2-5 amino acids and is easy to absorb by the organism, the sensitization property is further reduced, and the product activity is high; and the preparation method is simple to operate and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of biochemistry, and relates to a formula food for special medical use and its preparation method, as well as its use in the preparation of medical drugs, in particular to a whey protein peptide prepared by enzymatically hydrolyzing whey protein, and Its preparation method and an application for preparing medical medicine. Background technique [0002] The study of milk-derived bioactive peptides began in 1979. Brantl et al. in Germany obtained some peptide products by enzymatically hydrolyzing bovine milk casein, and proved that they had morphine-like activity. Since then, people have started research on bioactive peptides. After nearly 20 years of exploration, so far, a variety of milk-derived bioactive peptides have been discovered. The research on ACE inhibitory peptides derived from milk protein is more in-depth abroad, especially in Japan, which has made more research on ACE inhibitory peptides derived from whe...

Claims

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Application Information

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IPC IPC(8): A23L33/00A23L33/10A23L33/15A61K38/01A61P25/22A61P25/18A61K31/519A61K31/455
CPCA23V2002/00A61K31/455A61K31/519A61K38/01A61K2300/00A23V2200/30A23V2250/55A23V2250/7056A23V2250/7046
Inventor 熊良钟
Owner 中健医用食品有限公司
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