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V emulsion nicotinate for injection and its preparing method

A technology of nicotinic acid ester and injection, which is applied in the field of medicine

Inactive Publication Date: 2005-01-12
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

V E The injection of nicotinic acid ester has not been reported, we made it into injection emulsion, and the results of pharmacological tests showed that it has good curative effect, but oral administration of VE nicotinic acid ester with the same dose is ineffective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Composition is an effective dose of V E Nicotinic acid ester 2.5g, phospholipid 0.9g, poloxamer 0.3g, soybean oil 12.5g, glycerin 2.2g, sodium hydroxide appropriate amount, the rest is water for injection, a total of 100ml.

[0024] Manufacturing method:

[0025] 1. Prepare the oil phase in the preparation tank: In the preparation tank, heat the soybean oil to 90°C, add phospholipids, stir vigorously until dissolved, cool down to 50°C, add the drug, and stir vigorously for 5 minutes;

[0026] 2. Prepare the water phase in the preparation tank: add poloxamer and glycerin to the water for injection, stir at 70°C for 5 minutes to make them completely miscible;

[0027] 3. At 40°C, add the oil phase to the water phase and stir vigorously for 12 minutes to form colostrum;

[0028] 4. Use an appropriate amount of sodium hydroxide solution to adjust the pH value to 9;

[0029] 5. Pass the homogenizer, adjust the homogenization pressure to 600kg / cm in the first step 2 , the...

Embodiment 2

[0031] Composition is an effective dose of V E Nicotinic acid ester 2.5g, phospholipid 0.8g, HS15 0.4g, camellia oil 20g, glycerin 2g, hydrochloric acid amount, the rest is water for injection, 100ml in total.

[0032] Manufacturing method:

[0033] 1. Prepare the oil phase in the preparation tank: In the preparation tank, heat the camellia oil to 80°C, add phospholipids, stir vigorously until dissolved, cool down to 45°C, add the drug, and stir vigorously for 5 minutes;

[0034] 2. Prepare the water phase in the preparation tank: add HS15 and glycerin to the water for injection, stir at 70°C for 5 minutes to make them completely miscible;

[0035] 3. At 45°C, add the water phase to the oil phase and stir vigorously for 17 minutes to form colostrum;

[0036] 4. Use an appropriate amount of hydrochloric acid solution to adjust the pH value to 4;

[0037] 5. Pass the homogenizer, adjust the homogenization pressure to 580kg / cm in the first step 2 , the second step and then ad...

Embodiment 3

[0039] Composition is an effective dose of V E Nicotinic acid ester 2.5g, phospholipid 1.2g, olive oil 25g, glycerin 2.3g, sodium phosphate amount, the rest is water for injection, a total of 100ml.

[0040] Manufacturing method:

[0041] 1. Prepare the oil phase in the preparation tank: In the preparation tank, heat the olive oil to 70°C, add phospholipids, stir vigorously until dissolved, cool down to 40°C, add the drug, and stir vigorously for 5 minutes;

[0042] 2. Prepare the water phase in the preparation tank: add glycerin to the water for injection, stir at 70°C for 5 minutes to make it completely miscible;

[0043] 3. At 40°C, add the oil phase to the water phase and stir vigorously for 16 minutes to form colostrum;

[0044] 4. Use an appropriate amount of sodium phosphate solution to adjust the pH value to 7;

[0045] 5. Pass the homogenizer, adjust the homogenization pressure to 520 / cm in the first step 2 , the second step and then adjusted to 100kg / cm 2 , homo...

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Abstract

A VE nicotinate injection in the form of emulsion for preventing cerebral infarction is prepared from VE nicotinate, oil for injection, glycerine, emulsifier, coemulsifier and pH regulator. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and it is precisely a kind of V E Niacinate emulsion and its preparation method. Background technique: [0002] V E Nicotinic acid ester is a compound formed by esterification of vitamin E and niacin, and is a microcirculation activator. It not only has the respective physiological effects of vitamin E and niacin, eliminates the toxic and side effects caused by using vitamin E or niacin alone, but also has a synergistic effect. It has a more stable and lasting pharmacological effect than the combination of the two, and the effect is longer. Stablize. It can significantly inhibit platelet aggregation, directly act on blood vessel walls, relax peripheral blood vessels, promote blood circulation in the brain, skin, and muscles, and increase blood flow in a sustained and stable manner. Its effect of increasing the blood circulation of the brain and peripheral blood vessels is superior to that o...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/455A61P3/06A61P7/02
Inventor 邓意辉郑少辉吴琼赵妍雷杰杰王绍宁
Owner SHENYANG PHARMA UNIVERSITY
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