Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ezetimibe, simvastatin and nicotinic acid compound preparation and preparation method of ezetimibe, simvastatin and nicotinic acid compound preparation

A technology of ezetimibe and compound preparations, which is applied in the field of pharmaceutical preparations to achieve the effects of improving stability, simple operation, and convenient large-scale production

Inactive Publication Date: 2013-08-14
LIAONING YILING KECHUANG BIOLOGICAL MEDICAL TECH +1
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hypertensive patients are seldom able to insist on taking one or more antihypertensive drugs and lipid-lowering drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ezetimibe, simvastatin and nicotinic acid compound preparation and preparation method of ezetimibe, simvastatin and nicotinic acid compound preparation
  • Ezetimibe, simvastatin and nicotinic acid compound preparation and preparation method of ezetimibe, simvastatin and nicotinic acid compound preparation
  • Ezetimibe, simvastatin and nicotinic acid compound preparation and preparation method of ezetimibe, simvastatin and nicotinic acid compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 : Niacin / ezetimibe / simvastatin composition

[0050] In this implementation, ezetimibe was fully mixed with Kollidon VA64, a well-water-soluble carrier, to prepare a physical mixture, which was extruded through a twin-screw hot-melt extruder (Coperion KEYATE-20). The physical mixture was first put into the feeding In the feeder, it is sent to the heater area through the double helix rotation, and the physical mixture is extruded by the high mechanical force of the double helix and the temperature in the heater area, and the extruded item (glassy shape, relatively brittle) cools down Grind it into powder with a grinder at room temperature, and pass through a 100-mesh sieve. There are four temperature options in the heater zone: respectively set to Zone1 = 120 °C, Zone2 = 130 °C, Zone3 = 130 °C, Zone4 = 130 °C; the feeding speed and twin-screw extrusion speed are set to 2Hz.

[0051] In this implementation, the tablet core was prepared by mixing niacin with cor...

Embodiment 2

[0065] Example 2 Niacin / Ezetimibe / Simvastatin Composition

[0066] Table 6 Prescription quantity

[0067]

[0068] The preparation process of embodiment 2 refers to embodiment 1.

Embodiment 3

[0070] Table 7 Prescription amount

[0071]

[0072] The preparation process of embodiment 3 refers to embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of pharmaceutical preparations and particularly relates to a compound preparation which takes ezetimibe, simvastatin and nicotinic acid as effective components and has the effects of reducing blood pressure and blood lipid and a preparation method of the compound preparation. The compound preparation is a sustained release tablet. Aiming at the problems of poor water solubility of the ezetimibe, unstability of the simvastatin to acid and oxygen, and the like, the preparation method of the compound preparation adopts a melt extrusion technology for improving the dissolution rate of the ezetimibe, and adopts a cladding membrane technology for enhancing the stability of the simvastatin in a body so as to give full play to the efficacy of all components of the compound preparation and have the best synergy effect. The specific process comprises the steps of preparing the nicotinic acid into a tablet core as a sustained release part, spraying an isolating layer on the tablet core, then spraying the simvastatin and the ezetimibe on an outer layer of the sustained release part as a quick release layer, and then carrying out film coating on the quick release layer. The compound preparation provided by the invention is mainly applied to the treatment or prevention of diseases and indications associated with heart and cerebral vessels.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a compound preparation with ezetimibe, simvastatin and niacin as active ingredients and has blood pressure and lipid-lowering effects. Background technique [0002] Cardiovascular and cerebrovascular diseases are the main factors that threaten human life in the 21st century, and the death of cardiovascular and cerebrovascular diseases accounts for 40.8% of the deaths from chronic diseases in my country. Cardiovascular and cerebrovascular diseases are essentially vascular diseases. [0003] Clinical studies have shown that elevated levels of total cholesterol, low-density lipoprotein (LDL), and apolipoprotein can lead to atherosclerosis in humans. In addition, decreased levels of high-density lipoprotein (HDL) can also lead to atherosclerosis. Epidemiological studies have shown that the morbidity and mortality of cardiovascular diseases are directly proport...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/455A61K31/397A61K31/366A61K9/24A61P3/06A61P9/00A61P9/12A61P3/10A61P9/10
Inventor 关屹闫冬
Owner LIAONING YILING KECHUANG BIOLOGICAL MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com