The invention relates to a recombinant
engineering bacterium for producing a
pyrone derivative as well as a construction method and application of the recombinant
engineering bacterium, and belongs to the technical field of
biological engineering. By optimizing the metabolic flux of
malonyl coenzyme A and 3-hydroxy propionyl
coenzyme A, a novel
pyrone derivative 4-hydroxy-6-hydroxyethyl-2-
pyrone (HHEP) is obtained, a complete
heterologous synthesis path of the pyrone derivative 4-hydroxy-6-hydroxyethyl-2-pyrone (HHEP) is constructed in recombinant
engineering bacteria, efficient
de novo synthesis of the HHEP is realized, the yield of the HHEP is increased, and the yield of the HHEP is increased. Glucose is used as a single
carbon source, a toxic
reagent or a complex purification process is not needed, and the
shake flask yield of HHEP within 120 hours reaches 3.6 g / L. The HHEP has
antibacterial activity, and a breakthrough technical scheme is provided for low-cost and sustainable manufacturing of a novel
antibacterial agent. Meanwhile, the recombinant engineering bacterium provides a breakthrough technical scheme for low-cost and sustainable manufacturing of the HHEP.