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3 results about "Nonribosomal peptide" patented technology
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Nonribosomal peptides (NRP) are a class of peptide secondary metabolites, usually produced by microorganisms like bacteria and fungi. Nonribosomal peptides are also found in higher organisms, such as nudibranchs, but are thought to be made by bacteria inside these organisms. While there exist a wide range of peptides that are not synthesized by ribosomes, the term nonribosomal peptide typically refers to a very specific set of these as discussed in this article.
Bioengineering of modular polyketide synthases
The present invention provides a chimeric polyketide synthase (PKS) or polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) and uses thereof, wherein the PKS or PKS-NRPS comprises two or more recombinant units (RUs) linked to each other, wherein each RU comprises one or two or more contiguous domains derived from a parent PKS or PKS-NRPS, and the junction of at least one RU is defined by a recombination site selected from a site at the LPTY (A / P) FQ (H / R) xRYWL motif located in the AT post- linker (RYWL motif site) and a site at the RL motif of ACP helix 0 (RL motif site); wherein the two or more RUs are not naturally linked to each other.
Owner:WESTLAKE UNIV
Bacillus velezensis with broad-spectrum antibacterial activity and application thereof in prevention and treatment of necrotic enteritis of poultry
This invention discloses a strain of *Bacillus belyceae* with broad-spectrum antibacterial activity and its application in the prevention and treatment of necrotic enteritis in poultry. The *Bacillus belyceae* strain provided by this invention (… Bacillus from Velez The genome of strain GDG25CB056 is approximately 3.91 Mb in size, contains no virulence factors, and is rich in gene clusters encoding non-ribosomal peptides and polyketide synthases. Studies have confirmed that this strain exhibits significant growth advantages, strong tolerance to high temperatures, gastric acid, and bile salts, which facilitates intestinal colonization. It can produce siderophores and various enzymes, and has overcome the technical bottleneck of a narrow antibacterial spectrum, possessing broad-spectrum antibacterial activity, especially strong specific antagonistic activity against Clostridium perfringens. In vivo experiments have shown that this strain can significantly reduce the Clostridium perfringens load in the cecum of chicks with necrotizing enterocolitis, alleviate intestinal congestion and swelling, repair damaged intestinal villi, and enhance mucosal barrier function, providing a safe and efficient strain resource for the prevention and treatment of bacterial enteric diseases.
Owner:SOUTH CHINA AGRICULTURAL UNIVERSITY
An antitumor polyketide-nonribosomal peptide hybrid, method of preparation and use
ActiveCN118027044BHas cancer treatment activityHas anti-tumor protective activityPolyketideHybrid compound
The application belongs to the technical field of medical compounds, and particularly relates to an anti-tumor polyketide-nonribosomal peptide hybrid compound, a preparation method and application. The polyketide-nonribosomal peptide hybrid compound is compound 1 or compound 2, and structural formulas of the compound 1 and the compound 2 are as follows: The compound has anti-tumor activity, particularly anti-human breast cancer effect, and has relatively high anti-tumor activity.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV