Liposome preparations

Abstract

Pipecolic acid derivative-containing liposome preparations which are excellent in the immediate action and thus usable in an urgent situation such as brain infarction. These preparations are characterized by containing pipecolic acid derivatives or pharmaceutically acceptable salts thereof, which comprise the components as described in the description, as the active ingredient and lecithin as the major component of lipids forming liposomes, without resort to cholesterol as a stabilizer.

Description

field of invention [0001] The present invention relates to a liposomal preparation for pharmaceutical use containing a 2-pipericolic acid derivative, especially a macrolide compound, which has recently received special attention for its excellent immunosuppressive activity, such as A tricyclic compound of tacrolimus (FK 506) or a pharmaceutically acceptable salt thereof, as an active ingredient. More specifically, the present invention relates to a liposome preparation, which contains the above-mentioned active components stably encapsulated in liposomes, so it can be dissolved in various media such as physiological saline, glucose solution for injection, water or body fluids. It can be used in various administration methods, including injection methods such as intravenous injection, intramuscular injection and local injection for intra-articular injection, etc., local administration methods such as application to the skin, eye drops Internal, nasal and inhalational administr...

AI Technical Summary

Problems solved by technology

However, because liposome membranes are too stable, liposome preparations cannot show fast enough action like anticoagulants, fibrinolytics, and cerebral vasodilators used in the treatment of cerebral infarction

Images