The invention discloses a mosquito-repellent perfume and a preparation method thereof, and relates to a perfume. The invention provides a mosquito-repellent perfume having little dosage and long effective mosquito-repellent time, and a preparation method thereof. The mosquito-repellent perfume comprises the following raw materials in percentage by mass: 3 to 5 percent of deet, 3 to 5 percent of emulsifier, 0.2 to 0.5 percent of beta-cyclodextrine, 0.05 to 0.1 percent of methylparaben, 0.2 to 0.5 percent of perfume, 3 to 6 percent of glycerin, 0.7 to 1 percent of sodium chloride, 15 to 20 percent of ethanol and the balance of water. The preparation method comprises the following steps of: adding the water, the ethanol, the deet, the emulsifier and the beta-cyclodextrine into a reaction kettle, and stirring to obtain a mixture A; adding the glycerin and the perfume into the mixture A, and stirring to obtain a mixture B; and adding the methylparaben and the sodium chloride into the mixture B, stirring, standing and defoaming to obtain the mosquito-repellent perfume. The obtained mosquito-repellent perfume is transparent liquid.