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Biomarker compositions for diagnosing cervicitis and cervical cancer

A technology of biomarkers and compositions, applied in the field of biomarker compositions for diagnosing cervicitis and cervical cancer

Inactive Publication Date: 2016-11-16
上海阿趣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The presence of HPV alone is only an indicator of infection, not of high-grade cervical disease, so testing for HPV infection alone results in many false positives

Method used

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  • Biomarker compositions for diagnosing cervicitis and cervical cancer
  • Biomarker compositions for diagnosing cervicitis and cervical cancer
  • Biomarker compositions for diagnosing cervicitis and cervical cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0134] Embodiment 1: Embodiment 1 provides a biomarker composition for diagnosing cervicitis and cervical cancer, including at least disodium 5'-uridine, histamine, 3'-methoxyguanosine, benzene One or a combination of lactic acids.

Embodiment approach 2

[0135] Embodiment 2: Embodiment 2 provides a biomarker composition for diagnosing cervicitis, including: 5'-uridine disodium, L-cysteine, isocitrate, uridine diphosphate Sugar, adenosine monophosphate, inosine 5'-monophosphate, L-hexahydropyridinecarboxylic acid, N-acetylputrescine, sucrose, or a combination of several.

Embodiment approach 3

[0136] Embodiment 3: Embodiment 3 provides a biomarker composition for the diagnosis of cervical cancer, including: histamine, phenyllactic acid, citraconic acid, L-2-aminoadipic acid, 3'-O-methoxy One or a combination of guanosine, β-D-glucosamine, glycerol, and cholesterol sulfate.

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Abstract

The invention discloses biomarker compositions, and provides biomarker compositions for diagnosing cervicitis and a cervical cancer. The biomarker compositions are characterized by at least comprising one or a combination of uridine-5'-monophosphate disodium, histamine, 3'-O-methyl-guanosine and phenyllactic acid. The biomarker composition for diagnosing the cervicitis is characterized by comprising one or a combination of uridine-5'-monophosphate disodium, L-cysteine, isocitric acid, uridine diphosphate glucose, adenosine monophosphate, inosine 5'-monophosphate, L-pipecolic acid, N-acetyl putrescine and saccharose. The biomarker composition for diagnosing the cervical cancer is characterized by comprising one or a combination of histamine, phenyllactic acid, citraconic acid, L-2-aminoadipic acid, 3'-O-methyl-guanosine, beta-D-glucosamine, glycerin and cholesterol sulfate.

Description

technical field [0001] The present invention relates to a biomarker composition, and in particular to a biomarker composition for diagnosing cervicitis and cervical cancer. Background technique [0002] Cervicitis is one of the common gynecological diseases, including inflammation of the cervix and vagina and mucous membrane of the cervical canal. Because the squamous epithelium of the vagina of the cervix and the vagina are continuous, vaginitis can cause inflammation of the cervix and vagina. Since the epithelium of the cervical canal mucosa is a single layer of columnar epithelium, the anti-infection ability is poor and infection is prone to occur. The most common clinical cervicitis is acute endocervical mucositis. If acute cervicitis is not diagnosed and treated in time or pathogens persist, it can lead to chronic cervical inflammation. [0003] Cervical cancer is the second most common cancer in women, accounting for approximately 12% of all female cancers and causin...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N24/08G01N27/62G01N30/02
CPCG01N24/08G01N27/62G01N30/02G01N33/57484G01N2800/52
Inventor 邓军亮楼格尔吴洪强
Owner 上海阿趣生物科技有限公司
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